Buildings with different roofing systems possess different seismic performance during earthquake. Most of the traditional buildings are susceptible to earthquake disaster due to no seismic loading is considered in the design. In addition, irregular buildings have been proven to perform badly during earthquake events. Due to lack of investigations on asymmetrical timber-concrete hybrid building under earthquake loading, a ¼ of this type of building model was tested seismically using a unidirectional shake table. Four structural models with frequencies 3.85 Hz, 3.33 Hz, 2.70 Hz and 2.50 Hz varied using diagonal wooden braces and different roof materials namely heavy metal roof and clay roof tile. The models were subjected to El Centro ground motion excitations scaled to 0.08 g, 0.16 g, 0.24 g and 0.32 g PGA resembling 25%, 50%, 75% and 100% of the actual ground motion strength, respectively. Nine accelerometers and seven LVDTs were used to measure the seismic response of the models during shake table test for acceleration and displacement, respectively. Heavier roof material shows a different trend in the amplitudes across the maximum displacement time history, but a clear decrease in acceleration response for the roof level as compared with lighter roof material.