Abstract This paper presents an ultra-miniaturized skin implantable Multiple Input Multiple Output (MIMO) antenna for biotelemetry in the Industrial, Scientific, and Medical (ISM) band (2.4–2.48 GHz). The two-element configuration exhibits a compact planar volume of 4.5 × 6.2 × 0.25 mm³, with an edge-to-edge distance of 0.8 mm and a 75.85 % size reduction. Fabricated on a 0.25 mm thick Roger 10.2LM high permittivity substrate, the antenna achieves a Fractional Bandwidth (FBW) of 9.27 % and a realized gain of −28.2 dBi, with over 24.3 dB isolation across the entire band. Experimental results in multilayer animal tissue aligned well with simulations. Specific Absorption Rate (SAR) analysis at 1 W input power showed values of 848 W/kg (1-g) and 88.46 W/kg (10-g), yielding allowable input powers of 3.77 mW and 45.2 mW, respectively, adhering to international safety guidelines. The 2 × 2 element antenna demonstrated efficient communication over 7 m with a data rate of 78 Mbps/s. Multiple Input Multiple Output channel analysis revealed a Channel Capacity of 10.8 bps/Hz at a 20 dB SNR, nearly double that of an ideal Single Input Single Output system, making it suitable for high data rate skin-implantable applications.
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