Background: Thyroid abnormalities are a well-documented endocrine association seen in numerous dermatological conditions. However, there are few Indian studies analyzing the thyroid status in various dermatoses. Materials and Methods: This cross-sectional, observational study was conducted on 805 willing patients with various dermatoses, irrespective of the disease classification. Serum samples were taken and assayed for triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH). Results: Out of the 805 patients, 14.2% (n = 115) had abnormal thyroid function. Hypothyroidism accounted for 86.1% (n = 99) and hyperthyroidism for 13.9% (n = 16). Among the 99 hypothyroid patients, 23.2% (n = 23) had overt hypothyroidism while 76.8% (n = 76) had subclinical hypothyroidism. Vitiligo accounted for 36.1% (n = 291) of the patients, among which 12.3% (n = 36) had thyroid dysfunction involving six hypothyroid and three hyperthyroid cases. Out of 58 cases of melasma, 15 (25.8%) had abnormal thyroid function. Among the twenty patients with lichen planus pigmentosus, five had abnormal thyroid levels. Conclusion: This study demonstrates a strong association of thyroid disorders in certain conditions, such as vitiligo, alopecia areata, diffuse hair loss, dry skin, chronic urticaria, and melasma. Thus, the inclusion of thyroid function tests in routine investigations of these conditions would be helpful.