Abstract
BackgroundBoth dyslipidemia and thyroid dysfunction have a high prevalence rate and are important risk factors for cardiovascular diseases. However, the relationship between blood lipids and thyroid dysfunction is still controversial. This study aims to analyze the blood lipids in people with different thyroid functions.MethodsA total of 80937 adults were included in this population-based cross-sectional TIDE survey, which collected demographic and clinical data on thyroid function, blood lipid levels and other metabolic indicators. After screening, the final analysis included 10,747 participants, who were divided into hypothyroidism (n=311), subclinical hypothyroidism (n=5015), hyperthyroidism (n=203), subclinical hyperthyroidism (n=118) and control (n=5100) groups. The risk of dyslipidemia was analyzed by a logistic regression model and divided into groups of female menopausal.ResultsAfter full adjustment, significant associations were found between hypothyroidism and hypertriglyceridemia. Subclinical hypothyroidism was associated with a significantly higher risk of hypertriglyceridemia and hyper-low density lipoprotein cholesterolemia. Hyperthyroidism was significantly correlated with a reduced risk of hypercholesterolemia and hyper-low density lipoprotein cholesterolemia but positively correlated with the risk of low-high density lipoprotein cholesterolemia. There was no significant association between subclinical hyperthyroidism and blood lipids. Hypothyroidism increased the risk of hypertriglyceridemia in both premenopausal and postmenopausal females. Subclinical hypothyroidism was significantly associated with increased hypertriglyceridemia and low-high density lipoprotein cholesterolemia in premenopausal females. Hyperthyroidism was significantly associated with a reduced risk of hypercholesterolemia and hyper-low density lipoprotein cholesterolemia in premenopausal females and an increased risk of low-high density lipoprotein cholesterolemia in postmenopausal female.ConclusionAbnormal thyroid function has an important effect on blood lipids and is closely related to female menopause.
Highlights
Thyroid dysfunction is the most common disease in humans; the prevalence in China is as high as 15.22% and shows an upward trend [1]
Based on the TIDE data, this study found that in the disease spectrum of hypothyroidism-subclinical hypothyroidism-normal controlsubclinical hyperthyroidism-hyperthyroidism, the prevalence rates of dyslipidemia, hyperTG, hyperTC and hyperLDL-C showed a decreasing linear trend, while the prevalence of lowHDL-C showed a U-shaped curve
Premenopausal females with hypothyroidism and subclinical hypothyroidism had an increased risk of dyslipidemia, while premenopausal females with hyperthyroidism had a lower risk of hyperTC and hyperLDL-C
Summary
Thyroid dysfunction is the most common disease in humans; the prevalence in China is as high as 15.22% and shows an upward trend [1]. No significant changes in lipids were observed in patients with subclinical hypothyroidism compared with patients with normal thyroid function [5]. Duntas et al revealed that subclinical hypothyroidism patients with thyroid stimulating hormone (TSH)> 10 mU/L had higher levels of TC and LDL-C and lower levels of high-density lipoprotein cholesterol (HDL-C) [6]. The Norwegian HUNT study proved that even in people with normal thyroid function, TC, LDL-C, and TG increased with increasing TSH, while HDL-C decreased with increasing TSH [7]. Both dyslipidemia and thyroid dysfunction have a high prevalence rate and are important risk factors for cardiovascular diseases. This study aims to analyze the blood lipids in people with different thyroid functions
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