Ablation Depth Research Articles

Factors Predicting Slow Visual Recovery Following Hyperopic LASIK.

To identify factors predicting slow visual recovery following hyperopic laser in situ keratomileusis (LASIK). The study included consecutive patients who underwent hyperopic LASIK between January 2005 and December 2019 at a single medical center. Patients were divided into two groups according to whether they experienced normal recovery of visual acuity (1-week visit) or slow visual recovery (1-month visit). Visual recovery was defined as achieving an efficacy index of 0.9 or greater. Efficacy index was calculated as postoperative uncorrected distance visual acuity / preoperative corrected distance visual acuity. A comparison of baseline and intraoperative parameters was performed. Binary logistic regression was performed to identify potential predictors of slow visual recovery. Overall, 861 eyes of 861 patients were included. Mean age was 48.0 ± 9.5 years and 55.9% were women. Two hundred forty-nine patients (28.9%) experienced slow visual recovery. Younger age (P = .01), a larger preoperative spherical equivalence (P = .002), and greater maximum ablation depth (P = .002) were predictors of slow visual recovery. In binary logistic regression, female gender (P = .036) and greater spherical equivalence (P = .007) remained significant predictors of slow visual recovery. Female gender and greater preoperative spherical equivalence were associated with slow visual recovery. Patients may be advised accordingly. [J Refract Surg. 2024;40(1):e42-e47.].

The association of pre-photorefractive keratectomy Schirmer-1 test value with postoperative corneal epithelial thickness, ocular surface discomfort, and visual acuity.

To investigate the association of pre-photorefractive keratectomy Schirmer-1 test value with post-photorefractive keratectomy central corneal epithelial thickness, ocular surface disease index score, and uncorrected distance visual acuity. Patients were categorized according to preoperative Schirmer-1 value: the normal Schirmer Group (n=54; Schirmer-1 test value, >10 mm) and the low Schirmer Group (n=52; Schirmer-1 test value, between 6 and 10 mm). We analyzed ablation depth, visual acuity, result of Schirmer-1 test (with anesthesia), tear film break-up time, ocular surface disease index score, central corneal epithelial thickness, and spherical equivalent refraction. We found significant differences between the groups in Schirmer-1 test value, tear film break-up time, and ocular surface disease index score, both preoperatively and postoperatively (p<0.001). The preoperative central corneal epithelial thicknesses of the two groups were similar (p>0.05). After photorefractive keratectomy, the Schirmer-1 test value and spherical equivalent refraction decreased in both groups (p<0.05), and ocular surface disease index scores and central corneal epithelial thickness values increased in the low Schirmer Group (p<0.001) but not in the normal Schirmer Group (p>0.05). The postoperative central corneal epithelial thicknesses of the low Schirmer Group were significantly higher than those of the normal Schirmer Group (p<0.001). Postoperative uncorrected distance visual acuity did not differ significantly between the two groups (p>0.05). In patients with low Schirmer-1 test values before photorefractive keratectomy, the corneal epithelium thickened and ocular surface complaints increased during the postoperative period. However, changes in the corneal epithelium did not affect the postoperative uncorrected distance visual acuity. To reduce postoperative problems on the ocular surface in these patients, we recommend that dry eye be treated before photorefractive keratectomy.

The role of absorption mechanism on the optimization of processing commercial polymers under high repetition rate femtosecond laser irradiation

The response of three of the most used commercial polymers (poly(vinyl chloride) (PVC), poly(ethylene terephthalate) (PET) and polypropylene (PP)) under irradiation with high repetition rate (1 kHz–1 MHz) femtosecond (450 fs) multi-pulse (N = 10–1500) laser at λ = 343 nm, 515 nm (1.40 J/cm2 for both former wavelengths) and 1030 nm (1.70 J/cm2) is reported, obtaining a study on how the absorption mechanism influences the processing efficiency for these materials. Tunable ablation depth and diameters are accomplished by modifying repetition rates at a constant fluence and number of pulses. The results highlight the role of absorption mechanism, repetition rate ranges and thermal properties of the materials for benefiting ablation efficiency. Furthermore, the use of high repetition rates improves the laser processing, reducing extended thermal effects and increasing ablation uniformity.

Analysis of processing efficiency, surface, and bulk chemistry, and nanomechanical properties of the Monel® alloy 400 after ultrashort pulsed laser ablation

Monel® alloy 400 has excellent corrosion resistance and finds applications in marine industries. The processing of marine components requires high processing efficiency and a quality finish. Hence, this research aims to investigate the effects of the laser processing parameters such as laser fluence, scanning velocity, hatching distance, and the scanning pass on the ablation rates and efficiency, chemistry, and nanomechanical properties of the Monel® alloy 400 after pulsed picosecond (ps) laser ablation. From the experimental findings, the ablation depth increases as the laser fluence increases while decreasing as the scanning velocity increases. Surface roughness was noted to increase as the laser fluence increased. The findings demonstrated that the ablation rate increases as laser fluence increases while ablation efficiency decreases. Energy dispersive x-ray spectroscopy (EDX) showed that the elemental composition of laser-ablated zones is almost similar to that of the polished sample. X-ray spectroscopy (XPS) shows that the outer layer on the surface of Monel® alloy 400 is composed of NiO and CuO. The hardness and Young’s modulus of the laser-processed alloy were found to be less than those of the bulk material. This study can be used to establish optimal processing parameters for the ultrafast ps laser processing of materials to achieve high ablation efficiency with a high-quality surface finish for industrial applications.

Characterization of postoperative LASIK ectasia features on higher-order aberration excimer ablation maps

BackgroundTo characterize anterior corneal higher-order aberration (HOA) excimer ablation map patterns in postoperative LASIK ectasia (POE) and to examine correlations between newly identified corneal HOA ablation map features of POE and known topographic indices.MethodsProspective multicenter non-interventional descriptive study. A total of 28 eyes from 22 POE patients were enrolled. The postoperative HOA ablation map was derived from Topolyzer Vario corneal imaging at the time of POE diagnosis. Features that recurred were identified and then analyzed. Correlations to Orbscan indices were studied.ResultsAn arrangement of two elliptical paracentral ablation islands, deep inferior and shallow superior, in direct mirror-like opposition to each other, were identified on all HOA maps. The paracentral islands were accompanied by peripheral ablation crescents. The deep paracentral inferior island ‘hot spot’ coincided with the topographical apical POE cone and was highly reproducible in angular position (249.3 ± 17.3°). There was significant variation in ablation depth (shallow superior island: 11.5 ± 6.9 μm and deep inferior island: 32.5 ± 18.8 μm). The superior crescents had high variability in depth (34.8 ± 18.9 μm). Strong correlations were found between the corneal irregularity index and the ablation depth difference between the deep and shallow paracentral islands (R = 0.96; P < 0.0001).ConclusionThe corneal HOA excimer ablation map revealed a recurring, distinct, easily recognizable pattern in POE eyes. Validated Orbscan POE indices and HOA ablation map islands showed a strong correlation. It is possible to extract useful information from the corneal HOA ablation map, potentially making it suitable for diagnosing and monitoring POE although more studies are needed.

Wavelength selection for femtosecond laser processing of materials: Comparison of ablation efficiency and surface quality

We investigated the effects of the femtosecond laser wavelengths λ = 1035, 515, and 345 nm on the laser ablation of 64FeNi alloy (Invar). The ablation rate and ablation efficiency for the three wavelengths were obtained through material-removal experiments of stationary irradiation and laser scanning, respectively. Among laser–matter interaction parameters, the effective penetration depth (α−1) and ablation threshold fluence (Fth) could be estimated from the experiments and were found to be proportional to λ. The ablation rate and ablation efficiency for the peak fluence range of 0.2 J/cm2 < F0 < 1.0 J/cm2 and F0 > 1.0 J/cm2 were the highest at λ = 515 and 1035 nm, respectively, which could be confirmed by using analytical models with α−1 and Fth. The smoothest (roughest) processed surfaces could be obtained at λ = 345 nm (1035 nm) owing to the shortest (longest) periodicity of laser-induced periodic surface structures. Thus, surface smoothing at λ = 345 nm over a certain ablation depth after ablation at λ = 1035 nm, i.e., double-wavelength ablation, can be used for improving surface quality. These results can help in the selection of the proper λ for implementing precise laser micromachining with high productivity.

How long does the recovery of corneal sensitivity in different corneal regions take after LASEK?

To determine the corneal sensitivity recovery period after laser-assisted sub-epithelial keratectomy (LASEK) refractive surgery and investigate the effects of ablation depth on it. In this study examinations were performed on 90 right eyes of 90 people (34 males and 56 females) with an age range of 20-35 and an average of 22.26±3.8 years old. A sensation of 5 corneal regions, including the center and 4 mid-peripheral regions, i.e., nasal, inferior, temporal, and superior, each at a distance of 2 mm from the center of the cornea were measured with a Cochet-Bonnet esthesiometer device in 3-time points including before LASEK, 1 and 3mo after the surgery, respectively. LASEK was performed on individuals with stabilized myopia of -1.00 to -7.00 diopters and astigmatism of less than 2.00 diopters. Furthermore, the individuals were divided into three groups regarding ablation depth. The highest level of corneal sensitivity before surgery was related to the center of the cornea (59.1±7.76), and the highest level of corneal sensitivity loss was also related to this region. The sensation of all measured corneal regions significantly reduced 1mo postoperatively and returned to their preoperative levels 3mo after surgery (mean of 5 corneal regions in levels of preoperation: 58.2±6.48, 1mo postoperation: 57.3±5.84, 3mo postoperation: 58.2±5.49; P<0.05). A significant relationship was found between ablation depth and corneal sensitivity changes in the center and temporal regions (P<0.05). Corneal sensitivity in myopia and low astigmatism decreases after LASEK and reaches the preoperative level within 3mo. The depth of ablation during surgery affected the recovery of corneal sensitivity.

Understanding the role of oxide layers on color generation and surface characteristics in nanosecond laser color marking of stainless steel

This study conducts an experimental analysis of Laser Color Marking (LCM) on Stainless Steel, aiming to elucidate the role of oxides in color formation. Employing a nanosecond pulsed fiber laser, we systematically varied process parameters to successfully generate a diverse array of distinctive colors. Remarkably, a myriad of colors became evident at the micro-scale, offering a striking contrast to the macroscopic view dominated by a singular prominent color. These colors exhibited a notable increase in oxygen composition, reaching levels as high as 24.5%, coupled with the formation of a thin oxide film spanning thicknesses from 220 to 850 nm. The prevalence of chromium oxides resulted in greenish or bluish shades, whereas iron oxides’ dominance produced brownish and reddish hues. Particularly intriguing was the revelation of a multi-layer oxide film in samples like brown. Furthermore, the nature of oxides was also found to have an influence on surface characteristics. Chromium oxide-dominated colors exhibited ablation depth, while iron oxide-dominated colors resulted in surface overgrowth due to their porous nature. Correspondingly, Vickers hardness of samples dominated by chromium oxides showcased a significant enhancement in microhardness compared to those with iron oxide dominance. Lastly, we observed minimal degradation in surface roughness characteristics after LCM, with variations ranging from 262 nm to 463 nm, compared to 150 nm for untreated samples. These comprehensive findings provide valuable insights for optimizing the LCM process for stainless-steel color markings.

Chemical and Topographical Changes upon Sub‐100‐nm Laser‐Induced Periodic Surface Structure Formation on Titanium Alloy: The Influence of Laser Pulse Repetition Rate and Number of Over‐Scans

Titanium and its alloys are known to allow the straightforward laser‐based manufacturing of ordered surface nanostructures, so‐called high spatial frequency laser‐induced periodic surface structures (HSFL). These structures exhibit sub‐100 nm spatial periods – far below the optical diffraction limit. The resulting surface functionalities are usually enabled by both, topographic and chemical alterations of the nanostructured surfaces. For exploring these effects, multi‐method characterizations were performed here for HSFL processed on Ti–6Al–4V alloy upon irradiation with near‐infrared ps‐laser pulses (1030 nm, ≈1 ps pulse duration, 1–400 kHz) under different laser scan processing conditions, i.e., by systematically varying the pulse repetition frequency and the number of laser irradiation passes. The sample characterization involved morphological and topographical investigations by scanning electron microscopy (SEM), atomic force microscopy (AFM), tactile stylus profilometry, as well as near‐surface chemical analyses hard X‐ray photoelectron spectroscopy (HAXPES) and depth‐profiling time‐of‐flight secondary ion mass spectrometry (ToF‐SIMS). This provides a quantification of the laser ablation depth, the geometrical HSFL characteristics and enables new insights into the depth extent and the nature of the non‐ablative laser‐induced near‐surface oxidation accompanying these nanostructures. This allows to answer the questions how the processing of HSFL can be industrially scaled up, and whether the latter is limited by heat‐accumulation effects.

Impact of skin hydration on patterns of microthermal injury produced by fractional CO2 laser.

The impact of skin hydration on patterns of thermal injury produced by ablative fractional lasers (AFLs) is insufficiently examined under standardized conditions. Using skin with three different hydration levels, this study assessed the effect of hydration status on microchannel dimensions generated by a fractional CO2 laser. A hydration model (hyperhydrated-, dehydrated- and control) was established in ex vivo porcine skin, validated by changes in surface conductance and sample mass. After, samples underwent AFL exposure using a CO2 laser (10,600 nm) at two examined pulse energies (10 and 30 mJ/mb, fixed 10% density, six repetitions per group). Histological assessment of distinct microchannels (n = 60) determined three standardized endpoints in H&E sections: (1) depth of microthermal treatment zones (MTZs),(2) depth of microscopic ablation zones (MAZs), and (3) coagulation zone (CZ) thickness. As a supplemental in vivo assessment, the same laser settings were applied to hyperhydrated- (7-h occlusion) and normohydrated forearm skin (no pretreatment) of a human volunteer. Blinded measurement of MAZ depth (n = 30) was performed using noninvasive optical coherence tomography (OCT). Modest differences in microchannel dimensions were shown between hyperhydrated, dehydrated and control skin at both high and low pulse energy. Compared to controls, hyperhydration led to median reductions in MTZ and MAZ depth ranging from 5% to 8% (control vs. hyperhydrated at 30 mJ/mb; 848 vs. 797 µm (p < 0.003) (MAZ); 928 vs. 856 µm (p < 0.003) (MTZ)), while 14%-16% reductions were shown in dehydrated skin (control vs. dehydrated at 30 mJ/mb; MAZ: 848 vs. 727 µm (p < 0.003); MTZ: 928 vs. 782 µm (p < 0.003)). The impact of skin hydration on CZ thickness was in contrast limited. Corresponding with ex vivo findings, hyperhydration was similarly associated with lower ablative depth in vivo skin. Thus, median MAZ depth in hydrated skin was 10% and 14% lower than in control areas at 10 and 30 mJ/mb pulse energy, respectively (10 mJ: 210 vs. 180 µm (p < 0.001); 30 mJ: 335 vs. 300 µm (p < 0.001)). Skin hydration status can exert a minimal impact on patterns of microthermal injury produced by fractional CO2 lasers, although the clinical implication in the context of laser therapy requires further study.

Numerical simulation and experimental study of femtosecond laser ablation of copper: A two-temperature model with temperature-dependent properties and multiple phase transitions

A fundamental study of the interaction between femtosecond laser and copper will be useful in optimizing laser parameters and processing quality in practice, and it faces challenges due to very short action time, complex energy transport and phase transition processes of this interaction. In this paper, A 2D two-temperature model was established and improved to include temperature-dependent optical and thermophysical properties and three phase transitions including melting, vaporization, and phase explosion. The temperature evolution of both the top surface and the sub-surface were simulated, thereafter, ablation experiments with different laser peak fluences were conducted using a femtosecond laser. It was found that the interface reflectivity would decrease rapidly, while the optical penetration depth and the ballistic electron penetration depth would increase significantly during laser irradiation. The temperature evolution of electron and lattice subsystems of the top surface could be divided into, respectively, 4 and 5 stages with different temperature trends in each stage. The variation of subsurface temperature was different from that of surface temperature and the temperature distribution showed that there was a temperature peak at near surface. A comparison of the experimental and simulation results showed that the simulated ablation depths were consistent with the experiment results.

Comparison of errors in ablation depth calculation after myopic femtosecond laser in situ keratomileusis in patients with different degrees of myopia: a prospective study

BackgroundTo investigate the difference between the predicted preoperative corneal ablation depth and the measured ablation depth for femtosecond laser in situ keratomileusis (FS-LASIK) in patients with different degrees of myopia, and to analyze the source of the difference.MethodsA total of 55 patients (109 eyes) were included in this study. Multiple logistics regression was applied to analyze the sources affecting postoperative refractive outcomes. The difference between the preoperative predicted corneal ablation depth and the 1-day postoperative ablation depth in patients with different degrees of myopia was explored using linear regression. Corneal biomechanical parameters influencing error in ablation depth calculation were examined using multiple linear regression.ResultsOne hundred and nine eyes were divided into low to moderate myopia (55 eyes, myopia of 6 D or less), high myopia (45 eyes, myopia ranging from 6 D to a maximum of 9 D), and very high myopia group (9 eyes, myopia greater than 9 D) based on preoperative refractive error (spherical equivalent). Postoperative visual outcomes were comparable among the three groups of patients, with no significant difference in uncorrected visual acuity (UCVA). We did find notable disparities in spherical equivalent (SE) and central corneal thickness (CCT) in patients with different degrees of myopia at 1 day postoperatively (all p < 0.001). Logistic regression analysis showed that error in ablation depth calculation was an independent risk factor for refractive outcomes one day after surgery (OR = 1.689, 95% CI: 1.366 – 2.089). There was a substantial discrepancy in error in ablation depth calculation at 1 day postoperatively between the three groups. The measured ablation depth of the laser platform was lower than the predicted ablation depth in the low to moderate myopia and very high myopia groups, but the opposite was true in the high myopia group. Pre-operative SE (p < 0.001) and corneal front minimum radius of curvature (Front Rmin) (p = 0.007) obviously influenced the error in ablation depth calculation.ConclusionsError in ablation depth calculation values vary significantly between patients with different degrees of myopia and correlate highly with preoperative SE and Front Rmin. At the same time, the available evidence suggests that error in ablation depth calculation is an influential factor in postoperative refractive status, so it is imperative to control error in ablation depth calculation.

"Ice and Fire" Supramolecular Cell-Conjugation Drug Delivery Platform for Deep Tumor Ablation and Boosted Antitumor Immunity.

Cancer recurrence and metastasis are two major challenges in the current clinical therapy. In this work, a novel diketopyrrolopyrrole-based photothermal reagent (DCN) with unique J-aggregation-induced redshift is synthesized to achieve efficient tumor thermal ablation under safe power (0.33Wcm-2 ). Meanwhile, S-nitroso-N-acetylpenicillamine (SNAP) is co-loaded with near-infrared-absorbing DCN in amphiphilic polymers to realize heat-induced massive release of nitric oxide (NO), which can form oxidant peroxynitrite (ONOO- ) to active matrix metalloproteinases (MMPs), thereby degrading the compact tumor extracellular matrix to improve the ablation depth and infiltration of immune cells. Through a facile supramolecular assembly method, the DCN/SNAP nanoparticles are anchored to liquid-nitrogen-frozen cancer cells, achieving enhanced antitumor immune responses and effective inhibition of distant tumors and pulmonary metastases after only one treatment. The safety and effectiveness of this supramolecular cell-conjugation platform are verified by 2D/3D cellular experiments and bilateral tumor model, confirming the thermal-ablation-gas-permeation-antigen-presentation therapeutic mode has promising anticancer prospects.

Overview of Benchtop Models for Comparison of Surgical Treatments for Benign Prostatic Hyperplasia.

Benign prostatic hyperplasia (BPH) is a disease of the lower urinary tract which often requires surgical treatment. Recently, there has been a deluge of new treatment options, rarely validated or compared to current treatments on a benchtop model. The purpose of this review is to examine the literature and report which benchtop models are currently being used, which therapies have been tested on them, and what outcomes are being studied on each model. There are various benchtop models to choose from, each with their unique benefits and drawbacks. Perfused porcine kidney models are used to assess bleeding on the benchtop, ex-vivo human prostate helps to see specific interactions of devices with the prostatic tissue, and all other models have evaluated tissue ablation rates and depth of coagulation. There are currently no synthetic or non-animal tissues being used for this purpose, and surgical techniques such as enucleation, water-jet ablation, prostate stents, and water vapor thermal therapy have no representation in these benchtop tests. Benchtop testing serves an important role in the evaluation and comparison of surgical treatments for BPH. This testing allows these therapies to be objectively compared to one another, helping novel medical devices in their path to market and urologists make treatment decisions. Future directions may include further validation of the animal models currently being used and development of synthetic models which mimic the prostate on the benchtop.

Corneal epithelial remodeling induced by combined small incision lenticule extraction and accelerated corneal collagen crosslinking for myopia

To evaluate the changes of the corneal epithelial thickness (ET) profile induced by combined small incision lenticule extraction and accelerated corneal collagen crosslinking (SMILE-xtra) for myopia compared with the standard small incision lenticule extraction (SMILE). Nuri Eye Hospital, 61, Dunsan-ro, Seo-gu, Daejeon, 35233, Korea. Retrospective cross-sectional study. Thirty-one myopic eye undergoing SMILE-xtra and control group of 36 myopic eyes undergoing SMILE were retrospectively analyzed. Spectral-domain optical coherence tomography (CIRRUS™ HD-OCT 5000, ZEISS, Dublin, CA) was used to measure corneal ET of 17 zones within the central 7-mm zone at preoperative, postoperative 1 month, 3 months and 6 months. Postoperative ET alterations were analyzed for correlation with treatment parameters. There was no difference in preoperative mean age, postoperative MRSE, visual acuity, and ablation depth between the two groups, and there was a significant difference in preoperative central corneal thickness. Both groups showed the greatest increase in corneal ET in the paracentral area on the inferotemporal area, respectively, for 6 months. The preoperative MRSE and the ablation depth showed significant correlation with the postoperative epithelial thickening in mid-peripheral sectors in both groups, and significant negative correlations in paracentral sectors only in SMILE-xtra group. It is significant as the first study to compare corneal epithelial remodeling between SMILE and SMILE with accelerated corneal collagen crosslinking. The SMILE-xtra with the relatively large corneal ablation did not show a significant difference in the pattern of corneal epithelial remodeling compared to the SMILE group.

Numerical simulation and experimental validation of ultrafast laser ablation on aluminum

In this paper, a numerical study of the ultrashort single pulse ablation process in aluminum has been conducted using the two-temperature model, taking into consideration the several dependencies of the parameters on temperature. The evolution of temperatures for each point within the material over time is obtained, allowing to comprehend the distribution of energy in the laser-metal interaction and its subsequent diffusion within the material. This study allows to gain a more precise understanding of the thermophysical and optical properties throughout the material heating and ablation process. The ablation process has been experimentally validated using a femtosecond laser on a polished aluminum film for a wide range of fluences. The developed theoretical model and the experimental values are in good agreement for both ablation depth and diameter across the entire range of powers studied, enabling reliable determination of the threshold fluence, laser spot size and material absorption coefficient. These parameters are crucial for achieving optimal micromachining processes.

Investigation of NS-single-point laser ablation of bronze under different incidence angles and pulses

A fundamental understanding of ablation in different incidence angles is indispensable to expand the result to volume ablation where nonperpendicular irradiation exists. So far, no study with this orientation has been conducted in the category of volume laser machining. In this study, a nanosecond laser with different fluencies was utilized for single-point ablation experiments. The effect of incidence angles of 0°, 30°, and 60° on the ablation depth and the crater geometry was evaluated. Different laser pulse numbers are also considered. The results show that the ablation depth for 0° and 30° angles is almost in the same range for the initial pulses, but afterward, the ablation depth for the incidence 30° drops considerably. As the number of incident pulses increases, the ablation depth first develops approximately linearly and then grows exponentially. By changing the incident from 0° to 60°, the affecting area changes as well. The affecting area could be categorized into two distinct areas: (1) ablation area (A.A) where the crater ablation depth rapidly increases for the first 20 pulses and then, as more incident pulses arrive, it does not grow anymore and reaches a plateau due to the increase in the ablation depth. The second area (2) is the heat-affected area (H.A.A) of the crater where no further ablation occurs, but due to heat accumulation, it becomes constantly bigger when more incident pulses strike the crater. This heat-affected area tends to stay almost constant for the first incident pulses (up to 10) and, after a sharp increase, tends to enlarge steadily as the number of incident pulses rises to 70.

Simultaneous Topography-guided Custom Ablation With Corneal Cross-linking for Keratoconus: 10-Year Prospective Outcomes

Purpose: To assess 10-year visual and tomographic outcomes of topography-guided custom ablation (T-CAT) with corneal cross-linking (CXL) in eyes with keratoconus. Methods: T-CAT with CXL was performed in 600 eyes (522 patients). Based on the T-CAT ablation plan, the theoretical maximum ablation depth was 50 µm after epithelium removal. After ablation, accelerated corneal cross-linking (CXL) was performed in the central 8-mm zone (9 mW/cm 2 for 10 minutes in “epi-off” mode). The visual acuity and tomography were assessed. Results: There was significant improvement in uncorrected ( P = .001) and corrected ( P = .001) distance visual acuity after the procedure. Keratometry, root mean square lower order aberrations and higher order aberrations, defocus, coma 90°, and spherical aberration reduced significantly after surgery at 10 years of follow-up ( P &lt; .005). All Pentacam (Oculus Optikgerate GmbH) tomographic variables showed significant changes indicating regularization after T-CAT ( P &lt; .005). Flattening of greater than 5.00 diopters in maximum keratometry was noted in 6 eyes (1%). Two of 600 eyes progressed postoperatively and required repeat CXL. Conclusions: T-CAT plus CXL is a safe and effective technique even in the long term for regularizing the anterior corneal surface with significant visual improvement and reduction in higher order corneal aberrations. [ J Refract Surg . 2023;39(11):759–766.]

Laser-assisted grinding of RB-SiC composites: Laser ablation behavior and mechanism

Laser ablation is an important process during Laser-Assisted Grinding (LAG) of hard and brittle materials. To realize controllable material removal during laser ablation of RB-SiC composites, ablation experiments under different Laser Energy Density (LAED) and LAG experiments are conducted. Evolution rules and mechanism of physical phase, ablation morphology and crack characteristics caused by laser irradiation are investigated. The forces of LAG and Conventional Grinding (CG) are compared. The results show that ablation surface changes from slight oxidation to obvious material removal with LAED increasing, and ablation depth increases gradually. The ablation products change from submicron SiO2 particles to nanoscale particles and floccule. High LAED promotes SiC decomposition and sublimation, which leads to the increase of C element. The SiC phase forms corrugated shape in recast layer and columnar shape in Heat Affected Zone (HAZ) at 56 J/mm2. The cold and heat cycle leads to formation of fishbone crack. For ablation specimen under 30 J/mm2, the grinding force can be reduced by a maximum of 39% and brittle damage region is reduced. The material removal and microcrack generated will significantly reduce the hardness and improve machinability, which can promote grinding efficiency.

Femtosecond laser micro-machining of three-dimensional surface profiles on flat single crystal sapphire

In this study, a regression model is proposed using the machine learning (ML) method for femtosecond laser micro-machining of three-dimensional (3D) surface profiles on flat single-crystal sapphire. Based on the ML regression model, a quantitative relationship is established between the femtosecond laser processing parameters and the processed 3D functional curved surface topography. The combination of laser processing parameters (i.e. laser fluence F0, hatch dh, and scanning speed v) is also optimized according to the predicted parameters (i.e. surface quality Ra, ablation depth Z, and material removal rate MRR). Finally, the optimized combination of laser processing parameters was employed to process 3D surface profiles on flat single-crystal sapphire sheets. The maximum predicted profile error of the 3D structures was approximately 12.6% without any prior optimization experiments. Both the numerical simulation and experimental results demonstrate the feasibility of the proposed ML regression model in optimizing laser processing parameter combinations to achieve the desired 3D surface geometries on single-crystal sapphire by femtosecond laser micro-machining without trial-and-error.