Inclusion Ability Research Articles

Electrochemical One-Pot Synthesis of Cyclic Oligoglucosamines

Carbohydrates are known as the third chain of life, following DNA and proteins, and their roles extend beyond energy and structural materials to function as pharmaceuticals and cell recognition molecules (1. Among carbohydrates, sugar chains that undergo intramolecular glycosylation are called cyclic oligosaccharides; for example, cyclodextrins are a well-known example composed of six or more D-glucose unit. By utilizing the inclusion ability and molecular recognition ability of the cavities within cyclodextrins, applications such as drug delivery systems, functional materials, and pharmaceuticals have been developed (2. These functional developments are achieved through functional group transformations, although the adaptability of these transformations is partially challenging from the perspective of identifying the reactivity of hydroxyl groups. Therefore, for further functional development, a bottom-up synthesis starting from the monosaccharide is required.We have been focusing on the synthesis of cyclic oligosaccharides using D-glucosamine, which has an amino group at the 2-position of the pyranose ring (3. Although cyclic oligosaccharides are essentially repetitions of the same monosaccharide, sequential synthesis is required to distinguish between elongation and cyclization, leading to redundancy in the synthetic process. Therefore, we have focused on an organic electrochemical method (4, where we can control the initiation and termination of reactions by passing electric currents. To control both elongation and cyclization in one-pot, we synthesized building blocks containing 2,3-oxazolidinone, known to change its structure from the β-form to the α-form through thermodynamically controlled isomerization using acid (5. Using this building block, we achieved the synthesis of cyclic oligosaccharides containing α-1,4-glycosidic bonds from D-glucosamine in one-pot through a combination of two-stage electrolysis and acid-induced isomerization (6 (Figure a.). We will also present the α-selective synthesis of disaccharides containing oxazolidinone protecting groups, which significantly affect the formation of the cyclic structure, and their one-pot synthesis aiming to expand the substrate scope of cyclic oligosaccharides.We are also conducting research on establishing an electrochemical one-pot synthesis for β-1,6-cyclic oligoglucosamine, in addition to cyclic oligosaccharides containing α-1,4-glycosidic bonds. By introducing different protecting groups to the amino group of glucosamine and its hydroxyl groups, we have achieved control over the cyclic structure and polymerization degree of the products (Figure b.).1) Varki, A. Glycobiology, 2017, 27, 3.2) Szejtli, J. Chem. Rev., 1998, 98, 1743.3) Nokami, T. et al., Chem. Rec., 2021, 21, 2389.4) Baran, P. S. et al., Chem. Rev., 2017, 117, 13230.5) Kerns, R. J. et al., J. Am. Chem. Soc., 2001, 123, 9461.6) Nokami, T. et al., Chem. Commun., 2022, 58, 7948. Figure 1

The stabilization effects of macrocyclic hosts on novel sandwich dimers M2Cp2 (M = Be and Mg) and their fluoro derivatives

In this work, the host–guest chemistry of macrocyclic hosts with M2Cp2 (M = Be and Mg) and their fluoro derivatives (M2Cp2F10) have been systematically investigated by using DFT calculations. Four suitable host molecules were selected to encapsulate guest molecules to improve their structural stability. All hosts can form 1:1 inclusion complexes with M2Cp2 and M2Cp2F10, and the structural stability is mainly due to the non-bonding interactions. In comparison, the stabilizing effect of macrocyclic hosts on Mg2Cp2 is stronger than that on Be2Cp2, as do their fluoro derivatives, and the inclusion ability of prism[5]arene to Be2Cp2 is noteworthy.

Exploring the host compound dynamics of 1,4-phenylene-bis(di-p-fluorophenylmethanol) in mixed pyridines

AbstractIn this investigation, the wheel-and-axle host compound, 1,4-phenylene-bis(di-p-fluorophenylmethanol) (H), was demonstrated to have inclusion ability for each of PYR, 2MP, 3MP and 4MP (1:1, 1:2, 1:2 and 1:2 were the H: G ratios). In the equimolar guest competition experiments, H was observed to have an overwhelming affinity for PYR and 4MP relative to 2MP and 3MP. In fact, selectivity coefficients calculated from the non-equimolar binary guest competition experiments suggested that this host compound would be an efficient candidate for the separation of all PYR/2MP mixtures and a 40:60 4MP/3MP solution through host-guest chemistry strategies. SCXRD analyses established the preferred guests (PYR and 4MP) to be involved in significantly shorter stabilizing classical hydrogen bonding interactions with H, explaining the selectivity behaviour of this host compound in the guest mixtures. Additionally, Hirshfeld surface considerations also explained this behaviour, but only for PYR. Furthermore, thermal analyses were used to ascertain the relative thermal stabilities of the four complexes and, satisfyingly, the PYR- and 4MP-containing complexes possessed the greater thermal stabilities compared with H·2(2MP) and H·2(3MP), as was demonstrated by a comparison of their guest release onset temperatures.

Unravelling the impact of Al-Ti content on the microstructure-toughness relationship in the coarse-grained heated-affected zone of super-high-strength pipeline steels

This study aims to investigate the role of Al-Ti addition on particle modification in super-high-strength pipeline steels, and its following effect on microstructural evolution and impact toughness in the coarse-grained heated-affected zone (CGHAZ) is also explored. The steel plates with low and high Al-Ti content (0.009 wt-% Al + 0.006 wt-% Ti vs. 0.033 wt-% Al + 0.025 wt-% Ti), respectively, are subjected to gas metal arc welding with 6–7 kJ/cm heat input. The results reveal that the second-phase particles including micron-scale inclusion of Al-Mg oxide covered with CaS and nano-scale precipitate of titanium nitride are obtained in low Al-Ti steel, which are modified to the Al-Mg-Ti oxide core surrounded by CaS and TiN precipitate in high Al-Ti steel. The nano-scale TiN precipitate and micron-scale inclusion can restrict the austenite grain growth at high temperatures and induce acicular ferrite nucleation at medium temperatures, respectively, leading to the fine-grained mixed microstructure of bainite and acicular ferrite in CGHAZ of both steels. Because of the variant selection during the decomposition of austenite to bainite and acicular ferrite, those fine-grain structures with amounts of high-angle grain boundaries exhibit excellent CGHAZ toughness in both specimens. Compared with low Al-Ti steel, more precipitates induce smaller austenite grains, and the inclusions containing titanium increase the ability of inclusion to promote acicular ferrite nucleation in CGHAZ of high Al-Ti steel. Both of them resulted in smaller crystallographic grain and toughness improvement in CGHAZ of high Al-Ti steel than that in low Al-Ti steel.

Crystallization Behavior and Structure of CaO–SiO2–Al2O3 Melts Representing the Oxide Inclusions in Si‐Mn Deoxidized Steel

For further optimization of the inclusion plasticization control process of Si‐Mn deoxidized steel, the crystallization behavior and structure of CaO–SiO2–Al2O3 system inclusions are investigated. The crystallization behavior of four typical low melting point CaO–SiO2–Al2O3 inclusions at 1000 to 1250 °C is studied by steel crucible isothermal heating experiment. The obtained results reveal that the glassy stability of the inclusions is high when the composition of low melting point inclusion is located in the eutectic region of tridymite, pseudowollastonite, and anorthite in the ternary phase diagram. However, when the composition of the inclusion is located in the eutectic region of melilite, pseudowollastonite, and anorthite, it is easy to undergo glass‐crystallization transformation and precipitate wollastonite and anorthite crystalline phases when isothermal heating at 1100 to 1200 °C. In addition, the crystallization mode of these inclusions is mainly surface crystallization, and the crystallization degree of inclusions increases with the increase of heat treatment temperature and time. The activation energy of crystallization and the content of nonbridging oxygen in the silicate structure NBO/T can be used to predict the crystallization ability of inclusions. The greater the activation energy of crystallization and the smaller the NBO/T value, the higher the glassy stability of the inclusions.

Inclusion Complexation of Flavonoids with Cyclodextrin: Molecular Docking and Experimental Study

AbstractIn our work, the inclusion ability and binding pattern of flavonoids (catechin, iso‐liquiritigenin, luteolin, puerarin, rutin, and curcumin) with β‐cyclodextrin (β‐CD) and curcumin (CUR) with CDs (α‐CD, β‐CD, γ‐CD, dimethyl‐β‐CD, Hydroxypropyl‐β‐CD, and glucosyl‐β‐CD) were studied by molecular docking. The results showed that CUR among the six flavonoids was more likely to form stable inclusion complexes with β‐CD, and the HP‐β‐CD is the most suitable for CUR inclusion among the 6 types of CD. Phase solubility studies showed that CUR with β‐CD or HP‐β‐CD, respectively, could form stable inclusion complexes in a stoichiometric ratio of 1 : 1. The CUR/β‐CD and CUR/HP‐β‐CD inclusion complexes (ICs) were prepared by freeze‐drying method. The successful preparation of IC was confirmed by SEM images, FT‐IR spectra, and TG‐DSC. The results of in vitro release showed that the release of CUR from IC prepared with β‐CD or HP‐β‐CD could be improved significantly, and the release effect of HP‐β‐CD was better than that of β‐CD. The inclusion with CD could be used to improve the solubility and bioavailability of CUR.

Unique Organic Crystal Skeleton Based on N-Phenyl-Carbazole Derivatives with Adjustable Room Temperature Phosphorescence and Highly Stable Inclusion Ability to Dichloromethane.

Monosubstituted 9-(2-bromophenyl)-carbazole (1Br1CZ) and disubstituted 9,9'-(2,4-dibromo-1,3-phenylene) bis(9H-carbazole) (2Br2CZ) are synthesized by introducing bromine into ortho-phenyl position of 9-phenyl-carbazole (PhCZ). The decomposition temperature with 5% mass loss and melting point of 2Br2CZ crystal are 360 and 230°C. The highest occupied molecular orbital energy level of PhCZ is the highest, and that of 2Br2CZ is the lowest. The crystals of PhCZ, 1Br1CZ, and 2Br2CZ are monoclinic, orthorhombic, and triclinic system, which exhibit room temperature phosphorescence with lifetimes of 171.81, 37.15, and 28.77ms, and their corresponding phosphorescence quantum yields are 0.83%, 0.16%, and 4.58%. It theoretically reveals that six triplet energy levels (T1-T6) exist under S1 in 2Br2CZ crystal, and the spin orbit coupling constants between S1 and Tn in 2Br2CZ are also greater than those in PhCZ and 1Br1CZ, which promotes the intersystem crossing. Meanwhile, through crystal structure and Hirshfeld surface analysis, the torsion angles between the carbazole unit of 2Br2CZ and the central phenyl group reached 85.28°. The 2Br2CZ crystal exhibits the richest intermolecular interactions. A cavity of 4.498Å is formed within the crystal skeleton of 2Br2CZ, which can precisely fixe dichloromethane with a record-high desorption temperature over 145°C.

Improved precision at high-spatial resolution of strontium isotope analysis in apatite and apatite inclusions by LA-MC-ICP-MS with 1013 Ω amplifiers

Recent advancements in in situ analytical techniques have generated new interest in measuring strontium (Sr) isotopes in rock-forming apatite and apatite inclusions in zircon, because they can bring new insights into the primary signatures of magmatic sources. This paper introduces a novel approach based on laser ablation multi-collector inductively coupled plasma mass spectrometry (LA-MC-ICP-MS), which allows to achieve higher precision in situ analysis of Sr isotopes in small volumes of samples. The use of 1013 Ω current amplifiers for the acquisition of the signal on m/z 83, 83.5, 84, 85, 85.5, 86, 86.5, 87 and 88, along with a specific data reduction protocol, enhance both the internal precision and the external reproducibility of the 87Sr/86Sr ratio by a factor of four, presenting a significant improvement over the conventional use of 1011 Ω amplifiers. An internal precision better than 0.45‰ (i.e. 450 ppm; 2 s.e.) on the 87Sr/86Sr ratio can be achieved on the Durango apatite standard with a 13 μm square-shaped laser beam and a laser ablation pit of 60 μm depth. With a 5 μm beam, the precision is 2.2‰ on average with a 10 μm ablation pit depth for this standard. This analytical procedure was applied to investigate Sr isotopes in apatite and apatite inclusions within zircons from seven high BaSr magmatic rocks in the Northern Highland Terrane, Scotland. For these well-characterised, geochemically undisturbed samples, the data reveals similar Sr isotope compositions between apatite inclusions armoured in zircon, matrix apatites, and the bulk rock. This highlights the ability of apatite inclusions to faithfully record primary signatures of host magmas, elucidating their utility as reliable indicators in petrological studies of ancient samples.

Enhanced solubility and biological activities of Flufenamic acid through β-Cyclodextrin derivatives inclusion complexes: A comprehensive study

This study explores the formation of inclusion complexes between the solubility enhancement of Flufenamic acid (FNA) and various β-Cyclodextrins (β-CD, Hβ-CD, Mβ-CD, and Sβ-CD) using ultrasonic probe sonication method. The investigation encompasses a multi-faceted analysis, employing UV–Visible, FTIR, XRD, FE-SEM, TGA-DSC techniques and molecular docking studies. The UV–Visible spectra reveal absorption peak shifts and binding constants (Ka) indicate interaction strength, and thermodynamic parameters suggest spontaneous and favorable inclusion processes of β-CDs:FNA. Solid inclusion complexes of β-CDs:FNA were further characterized using FTIR, revealing alterations in functional groups indicative of complex formation. XRD analysis elucidates changes in crystallinity, while FE-SEM provides insights into morphological variations. Thermal stability is assessed through TGA-DSC, demonstrate the impact of inclusion on the complexes stability. Phase solubility diagrams illustrate the improved solubility of FNA in the presence of β-CDs. Mβ-CD:FNA exhibits the highest stability constant (1204 M−1), emphasizing its potential as an effective carrier. The binding energy of Mβ-CD:FNA (−46.72 kcal/mol) was lower than that of β-CD:FNA (−39.03 kcal/mol), Hβ-CD:FNA (−46.40 kcal/mol), and Sβ-CD:FNA (−46.29 kcal/mol), indicating that the hydroxypropyl group substitution enhanced the inclusion ability of β-CDs. Antibacterial activity studies against S. aureus and E. coli highlight enhanced efficacy of inclusion complexes with Mβ-CD:FNA (92.3 ± 0.18 % and 94.2 ± 0.17 %) demonstrating superior antibacterial activity. Cytotoxicity evaluations on HCT-116 cells reveal the safety profile of the β-CDs:FNA inclusion complexes, with Mβ-CD:FNA showing lower toxicity and high cell internalization compared to other formulations. The findings hold promise for applications in drug delivery, antimicrobial packaging, and the broader pharmaceutical and biotechnological fields.

Empowering Women through Tourism and Financial Development: Empirical Evidence from Upper Middle-Income Economies

The concept of women’s empowerment in this study focuses on international tourism, economic growth, financial development and financial inclusion among others as integral aspects that would help achieve the Sustainable Development Goals. Using panel data from 15 Upper Middle-Income Countries between 1995 and 2017, the study employs cutting edge approaches such as fixed-effect models, random effect models, GMM and robust LS regressions to identify major impacts. The results show a strong relationship between these factors regarding women’s empowerment with clear impacts on self-employment among the women and increased participation in serviceability and industrial areas. In particular, these factors play a very important role in total employment of women. The analysis reinforces the ability of international tourism, economic growth, financial development and financial inclusion to facilitate women’s empowerment in Upper Middle-Income Countries. This study illuminates the complex realities that guide how a woman participates in power structures, which partly exposes broad aspiration of sustainable development.

Versatile separation layer for separation and purification of ethanol/cyclohexane mixtures by pervaporation process

Quaternized cyclodextrin (CD) obtained by quaternization reaction of bromine-CD and N, N-Dimethylethylenediamine, are used for preparing PV membranes. Three different kinds of composite membranes are interfacially synthesized on the polyacrylonitrile substrate. The different sequences of piperazine and quaternized CD reacted with trimesoyl trichloride show a great difference in separation of polar/nonpolar mixture. The topmost layer of CD-based polyamide layer shows a higher separation factor, which can be inferred that quaternized CD played the major role during separation. Quaternized CD can integrate cavity size, polar and non-polar characteristics to achieve exceptional screening performance. PV performance of the optimal membrane at 25 °C is measured using the 5 wt% ethanol and cyclohexane mixture, exhibiting the separation factor of 66.7. PV performances of other different organic mixtures prove that nonpolar inner cavity of CD has a stronger inclusion of cyclohexane than other smaller nonpolar molecules, thus enhancing the repulsion of cyclohexane from the mixture. In summary, these outside polar quaternary ammonium salt structures of quaternized CD have a high selectivity for polar solvents. The nonpolar cavity of CD shows the inclusion ability of nonpolar solvents, especially the organic solvent with large molecular volume, which hinders their penetration and improves the separation factor.

Can financial inclusion reduce energy inequality? Evidence from China

ABSTRACT Energy inequality has been a hot topic in academia. This study first measures energy inequality in 25 Chinese provinces, and then investigates the interaction between financial inclusion and energy inequality. We also explore the potential impact mechanism behind the relationship. The primary findings reveal that: (i) Financial inclusion can help reduce energy inequality in China; moreover, the impact of financial inclusion varies according to regional consumption levels and environmental regulation. (ii) Technological innovation plays an important role in enhancing the ability of financial inclusion to reduce energy inequality. (iii) Fiscal revenue and energy consumption structure are two significant mediating factors through which energy inclusion affects energy inequality. (iv) Digital financial inclusion (DFI) has an inverted U-shaped impact on energy inequality. Overall, this research provides important insights into the impact of financial inclusion and offers several practical implications for reducing energy inequality in China.

Research on residual stress and hydrogen diffusion of X80 pipeline welded joint

Hydrogen enrichment induced by pipeline welding residual stress is a key issue affecting the safe service of hydrogen pipelines. In order to explore the influence of welding residual stress on hydrogen diffusion and the effect of heat treatment, an X80 pipeline model with a six-layer girth weld was established using ABAQUS software, and coupling analysis of temperature field, stress field, and hydrogen diffusion was carried out. The distribution of residual stress in the welding area and local inclusion area was analyzed, the relationship between the hydrostatic stress and hydrogen diffusion of the pipeline, and the influence of the direction and shape of the inclusion on hydrogen diffusion were explored, and the effect of post-weld heat treatment on the residual stress and hydrogen diffusion in the welding area and local inclusion area was studied. The hydrostatic stress curve is similar to the hydrogen concentration distribution curve, and hydrostatic stress can be considered the main driving force for hydrogen diffusion in the pipeline. As the angle between the inclusions and the hydrogen diffusion direction increases, the hydrogen diffusion flux will gradually decrease. The more slender the inclusions, the stronger the diffusion ability of parallel or 45° inclusions, and the weaker the diffusion ability of perpendicular inclusions. Hydrogen enrichment occurs in inclusions or inclusion boundaries before and after post-weld heat treatment of the pipeline, and the internal hydrogen concentration of hard inclusions is higher than that of soft inclusions. Post-weld heat treatment can significantly reduce welding residual stress and hydrostatic stress, thereby reducing hydrogen enrichment concentration.

Effects of Na2O, K2O and B2O3 on Deformability of SiO2-MnO-Al2O3 Inclusion in High-Carbon Steel

Cord steel is used for making tire frames and wire saws for cutting silicon wafers. The diameter of mainstream cutting wire has been developed to be lower than 100 μm. The size and deformation ability of inclusions are very important to the wire breaking rate of cord steel during the drawing process. In order to improve the deformation ability of the inclusions in cord steel, alkali metal oxide was added into the molten steel to improve the inclusions in the steel so as to obtain good, plastic, low-melting-point inclusions. Mass fractions of 0.3%, 0.5% and 1.0% K2CO3, Na2CO3 and B2O3 were added into cord steel, which were melted in 10 furnaces (including 0% alkali metal oxides, mass fractions of 0.3%/0.5%/1.0% K2CO3, Na2CO3 and B2O3). The morphology and composition of inclusions were observed by SEM-EDS. Factsage phase diagram calculations and experimental results show that, with the increase in Na2CO3 content in cord steel, the aluminum content in the inclusions gradually decreased. When the mass fraction of Na2CO3 was 0.5% per ton, most of the inclusions in the steel fell in the low melting point region (less than 1300 °C). With the increase in K2CO3 content in cord steel, the silicon content in the inclusions decreased gradually. When the mass fraction of K2CO3 was 0.5% per ton, most of the inclusions in the steel fell in the low melting point region. The deformation ability of the inclusions added with 0.5% Na2CO3 in the steel during forging was better than that of the inclusions added with 0.5% K2CO3. After adding B2O3, the inclusions in the steel were SiO2-MnO-Al2O3 inclusions or inclusions with SiO2-MnO-Al2O3 as the core and BN wrapped around. Boron could not be dissolved into the inclusions for plastic modification.

Financial Literacy, Financial Innovation, and Financial Inclusion as Mitigating Factors of the Adverse Effect of Corruption on Banking Stability Indicators

AbstractThe purpose of this study is to examine the ability of financial literacy, financial innovation, and financial inclusion to mitigate the adverse effect of corruption on banks’ credit risk, profitability, and financial stability, with this joint inclusion being the novelty explored. Furthermore, we aim to compare the results across four different groups of countries, namely African, Asian, American, and European countries. The Feasible Generalized Least Squares (FGLS) estimation results indicate that corruption increases credit risk, reducing profitability and bank stability, being these effects mitigated by financial literacy, financial innovation, and financial inclusion. Furthermore, we find that financial literacy, financial innovation, and financial inclusion reduce credit risk while increasing bank profitability and stability. These results enable policymakers and managers to promote inclusion, innovation, and financial literacy to achieve banking sector stability while combating corruption.

Liquid Structure Scenario of the Archetypal Supramolecular Deep Eutectic Solvent: Heptakis(2,6-di-O-methyl)-β-cyclodextrin/levulinic Acid.

The concept of supramolecular solvents has been recently introduced, and the extended liquid-state window accessible for mixtures of functionalized cyclodextrins (CDs) with hydrogen bond (HB) donor species, e.g., levulinic acid, led to the debut of supramolecular deep eutectic solvents (SUPRA-DES). These solvents retain CD's inclusion ability and complement it with enhanced solvation effectiveness due to an extended HB network. However, so far, these promising features were not rationalized in terms of a microscopic description, thus hindering a more complete capitalization. This is the first joint experimental and computational study on the archetypal SUPRA-DES: heptakis(2,6-di-O-methyl)-β-CD/levulinic acid (1:27). We used X-ray scattering to probe CD's aggregation level and molecular dynamics simulation to determine the nature of interactions between SUPRA-DES components. We discover that CDs are homogeneously distributed in bulk and that HB interactions, together with the electrostatic ones, play a major role in determining mutual interaction between components. However, dispersive forces act in synergy with HB to accomplish a fundamental task in hindering hydrophobic interactions between neighbor CDs and maintaining the system homogeneity. The mechanism of mutual solvation of CD and levulinic acid is fully described, providing fundamental indications on how to extend the spectrum of SUPRA-DES combinations. Overall, this study provides the key to interpreting structural organization and solvation tunability in SUPRA-DES to extend the range of sustainable applications for these new, unique solvents.

Nonmetallic inclusion characterizations and effects on impact toughness anisotropy of TWIP steel with different Ce additions

The effects of cerium (Ce) addition (0, 0.015% and 0.045%) on the microstructure, inclusions and impact toughness of Fe-18%Mn-0.6%C twinning-induced plasticity (TWIP) steel were investigated. The results show that the addition of Ce has no significant effect on the texture of TWIP steel. The grain size of TWIP steel decreases, and the volume fraction of twins increases slightly with Ce addition. Typical MnO-MgO-MnS complex inclusions and MnS were observed in TWIP steel without Ce. The inclusions gradually transform from the long strip MnS-Ce oxysulfide complex inclusions to ellipsoidal Ce oxysulfides with the increase in Ce addition from 0.015% to 0.045%. Notably, the transverse impact toughness of TWIP steel with 0.015% Ce addition is much lower than that of the other samples and exhibits serious anisotropy, and these differences are attributed to the stronger deformation ability of the complex inclusions with MnS and Ce oxysulfides compared with Ce oxysulfides. Fine grain size and ellipsoidal inclusions lead to excellent isotropic properties in TWIP steel with 0.045% Ce addition.

Reduced Graphene Oxide as a Platform for the Immobilization of Amino-Cyclodextrins.

In the present work, we reported on a method to combine amino β-cyclodextrins (CD1) with reduced graphene oxide (obtained by the electrochemical reduction of graphene oxide, erGO) to produce a glassy carbon electrode (GCE) modified with both CD1 and erGO (CD1-erGO/GCE). This procedure avoids the use of organic solvents such as hydrazine or long reaction times and high temperatures. The material combining both CD1 and erGO (CD1-erGO/GCE) was characterized by SEM, ATR-FTIR, Raman, XPS, and electrochemical techniques. As proof-of-concept, the determination of the pesticide carbendazim was carried out. The spectroscopic measurements, especially XPS, proved that CD1 was covalently attached to the surface of the erGO/GCE electrode. The attachment of cyclodextrin at the reduced graphene oxide produced an increase in the electrochemical behavior of the electrode. The cyclodextrin-functionalized reduced graphene oxide, CD1-erGO/GCE, showed a larger sensitivity (1.01 μA/μM) and a lower limit of detection for carbendazim (LOD = 0.50 μM) compared with the non-functionalized material, erGO/GCE, (sensitivity = 0.63 μA/μM and LOD = 4.32 μM, respectively). Overall, the results of the present work show that this simple method is suitable to attach cyclodextrins to graphene oxide, maintaining their inclusion abilities.

Research on the Construction of an Evaluation System of Commercial Banks' Service for Rural Revitalization under Common Prosperity -- Analysis Based on Entropy Weight TOPSIS Model

In the new stage of development, commercial banks actively play the role of high-quality financial services and contribute a vital force to revitalizing villages and the modernization of the Chinese style. This paper selects three dimensions of financial performance, serviceability for agriculture, rural areas, and farmers, and digital inclusion ability to construct an evaluation index system of commercial banks' service for rural revitalization, and uses the entropy weight TOPSIS model to measure its service level for rural regeneration. To simulate the evaluation process, this paper selects nine commercial banks as samples for measurement and data analysis. The study is helpful in comprehensively assessing the level of commercial banks' services for rural revitalization and provides the theoretical basis and data reference for bank managers, investors, and government departments.

Core issues, case studies, and the need for expanded Legacy African American genomics.

Introduction: Genomic studies of Legacy African Americans have a tangled and convoluted history in western science. In this review paper, core issues affecting African American genomic studies are addressed and two case studies, the New York African Burial Ground and the Gullah Geechee peoples, are presented to highlight the current status of genomic research among Africa Americans. Methods: To investigate our target population's core issues, a metadatabase derived from 22 publicly accessible databases were reviewed, evaluated, and synthesized to identify the core bioethical issues prevalent during the centuries of the African American presence in North America. The sequence of metadatabase development included 5 steps: identification of information, record screening and retention of topic relevant information, identification of eligibility via synthesis for concept identifications, and inclusion of studies used for conceptual summaries and studies used for genetic and genomic summaries. To these data we added our emic perspectives and specific insights from our case studies. Results: Overall, there is a paucity of existing research on underrepresent African American genomic diversity. In every category of genomic testing (i.e., diagnostic, clinical predictive, pharmacogenomic, direct-to-consumer, and tumor testing), African Americans are disproportionately underrepresented compared to European Americans. The first of our case studies is from the New York African Burial Ground Project where genomic studies of grave soil derived aDNA yields insights into the causes of death of 17th and 18th Century African Americans. In the second of our case studies, research among the Gullah Geechee people of the Carolina Lowcountry reveals a connection between genomic studies and health disparities. Discussion: African Americans have historically borne the brunt of the earliest biomedical studies used to generate and refine primitive concepts in genetics. As exploited victims these investigations, African American men, women, and children were subjected to an ethics-free western science. Now that bioethical safeguards have been added, underrepresented and marginalized people who were once the convenient targets of western science, are now excluded from its health-related benefits. Recommendations to enhance the inclusion of African Americans in global genomic databases and clinical trials should include the following: emphasis on the connection of inclusion to advances in precision medicine, emphasis on the relevance of inclusion to fundamental questions in human evolutionary biology, emphasis on the historical relevance of inclusion for Legacy African Americans, emphasis on the ability of inclusion to foster expanded scientific expertise in the target population, ethical engagement with their descendants, and increase the number of science researchers from these communities.