Objectives The purposes of this study were to investigated the effectiveness of scenario-based simulation prac-tice education for nursing students. Methods Data were collected through a questionnaire from 169 senior nursing students enrolled at a university in J city between April 15 and June 30, 2024. Quantitative data were gathered from these students, and qualitative data were collected through focus group interviews with 15 students who consented to participate. The quantita-tive data collection was conducted in two phases, pre- and post-surveys, using self-report questionnaires to as-sess problem-solving skills, critical thinking disposition, self-directed learning ability, communication skills, and grit. The data were then analyzed using descriptive statistics and paired t-tests. Qualitative data collection was conducted after the course grades were fully disclosed, as they could influence the research outcomes. Focus group interviews were held with three groups, each consisting of five students, and each interview lasted between 1.5 to 2 hours. The interview questions were provided in advance to allow participants time to reflect. During the qualitative data collection, four researchers took on roles as a moderator, two recorders, and one observer. All in-terviews were recorded and documented. Results In this study, quantitative research results showed that after scenario-based simulation practice educa-tion, nursing students' problem-solving abilities (t=-8.02, p=<.001), critical thinking disposition (t=-6.86, p=<.001), self-directed learning abilities (t=-6.10, p=<.001), communication skills (t=-3.62, p=<.001), and grit (t=-7.26, p=<.001) significantly improved. The qualitative research results, obtained through focus group inter-views, revealed three themes: the coexistence of positive and negative feelings towards the new educational method, the expansion and growth of knowledge through new educational experiences, and self-reflection through role experiences. Conclusions Through scenario-based simulation practice education, students had diverse experiences and showed improvements in cognitive aspects such as problem-solving abilities, critical thinking disposition, and communication skills. It was also confirmed that the integration of theory and practice and clinical performance abilities were enhanced. This study suggests that there is a continuous need for research comparing scenar-io-based simulation practice education with other teaching methods, involving comparison and control groups.