In this paper, we study codimension two holography in flat spacetimes, based on the idea of the wedge holography. We propose that a region in a $d+1$ dimensional flat spacetime surrounded by two end of the world-branes, which are given by $d$ dimensional hyperbolic spaces, is dual to a conformal field theory (CFT) on a $d-1$ dimensional sphere. Similarly, we also propose that a $d+1$ dimensional region in the flat spacetime bounded by two $d$ dimensional de Sitter spaces is holographically dual to a CFT on a $d-1$ dimensional sphere. Our calculations of the partition function, holographic entanglement entropy and two point functions, support these duality relations and imply that such CFTs are non-unitary. Finally, we glue these two dualities along null surfaces to realize a codimension two holography for a full Minkowski spacetime and discuss a possible connection to the celestial holography.