4th Volume Research Articles

An Exploration of the Aesthetic Value of Hu Shi s Ibsenism in Drama

The influence of Norwegian playwright Henrik Ibsen in China today is largely attributed to Hu Shi s introduction and evaluation of his works. Hu Shi wrote an article titled Ibsenism in Beijing on May 16, 1918, and revised it on April 26, 1919. This article was published on June 15, 1918, in the 4th volume, 6th issue of the New Youth magazine. Once published, it caused a significant stir in society. Consequently, a cultural transformation of realism emerged in China. Today, the study of Hu Shi s Ibsenism still holds great research value and significance. This paper aims to explore Hu Shi s Ibsenism to provide a strong theoretical support and practical basis for the development and construction of realism in creation and contemporary Chinese drama.

Abstract 105: Understanding the role of β2-adrenergic receptor signaling on type II innate lymphoid cells in cancer

Abstract Increased norepinephrine (NE) due to chronic stress can activate adrenergic receptors, specifically β2-adrenergic receptors (β2AR), to produce an immunosuppressive tumor microenvironment (TME). Previous work by our lab demonstrated that tumor burden can be reduced by blocking β2AR signaling. Immune cells express β2AR and we have shown that the increased β2AR signaling leads to increased T cell exhaustion and increased inhibitory activity of myeloid-derived suppressor cells (MDSCs). In general, the resulting immunosuppression leads to a modest but significant reduction in tumor growth. However, the lack of a dramatic reduction in tumor growth reveals the complex nature of adrenergic signaling dependent regulation of the cancer immune response. Recent literature revealed that innate lymphoid cells (ILCs), especially type II ILCs (ILC2s), express high levels of β2AR. Therefore, we evaluated whether β2AR regulates ILC2s within the TME and how that affects tumor prognosis. We generated a genetic conditional knockout murine model where β2AR expression in ILC2s was deleted by crossing IL5cre expressing mice to β2ARflox/flox mice (IL5creβ2ARf/f). AT3 breast cancer cell line was injected into the 4th mammary fat pad and tumor volume was measured every 2-3 days. Tumor infiltrating ILC2s (CD45+Lineage−CD90.2+CD127+ST2+) were analyzed by flow cytometry at D36 post-tumor implantation. Notably, IL5creβ2ARf/f mice had increased AT3 breast cancer tumor growth compared to control mice. Flow cytometric analysis of the tumor revealed an increased frequency of GATA3+ ILC2s within the TME. These GATA3+ ILC2s lacking β2AR expressed higher levels of the IL33 receptor, ST2, and a higher percentage of IL13+ cells compared to WT GATA3+ ILC2 cells. We also observe a trend toward increased MDSC population within the TME of mice lacking β2AR in ILC2s. These results reveal an anti-tumor function of β2AR signaling through the suppression of ILC2 activity within the TME that warrants further investigation. This work has been in part supported by NIH Grants F30 CA284763 (to J.C.), K99 HL155792 (to H.M.), and RO1 CA205246 (to E.R.) Citation Format: Jee Eun Choi, Cameron R. MacDonald, Saeed Daneshmandi, Jianmin Wang, Nathan T. Roberts, Caitlin M. James, Philip L. McCarthy, Hemn Mohammadpour, Elizabeth A. Repasky. Understanding the role of β2-adrenergic receptor signaling on type II innate lymphoid cells in cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 105.

Об издании заключительного тома «Писем» Вл.С. Соловьева (Т. 4. Пб.: Изд-во «Время», 1923): по материалам писем Г.П. Блока Э.Л. Радлову (1920‒1923 гг.). К 100-летнему юбилею издания. Приложение. Письма Г.П. Блока Э.Л. Радлову (30 октября 1920 – 7 мая 1923)

The article describes the history of the publication of the final 4 volum of the collection of “Letters” by V.S. Solovyov, published in 1923, in Soviet time, 15 years after the publication began (vol. 1) and 12 years after the release of the previous one (vol. 3), which, as is known, planned to complete the publication of the available at that moment of the philosopher’s letters. The acquisition of new letters prompted the historian of philosophy Ernest Lvovich Radlov (1854–1928), a friend and like-minded Solovyov, the permanent compiler and editor of the published volumes of his letters, to begin in 1919‒1920 in other cultural and historical conditions to prepare the 4th volume. The difficult history of the publication of the final volume has not yet received sufficient coverage in the literature about the philosopher. The publication of the surviving letters to Radlov the Editor-in-chief of the cooperative association “Vremya” G.P. Blok who worked on this volume during 1920–1923, to some extent illuminate the publishing process and the difficulties that arose during the preparation. Despite the fact that Radlov's response letters to the Block have not yet been revealed, the details reported in the letters allow us to restore the overall picture of both scientific and technical publishing work on the volume.

CONTRIBUTION BY THE BELARUSIAN DIOCESEES TO THE IMPLEMENTATION OF GRAND DUKE N. M. ROMANOV’S PROJECT “RUSSIAN PROVINCIAL NECROPOLIS"

The article presents the history of the project led by the Chairman of the Imperial Historical Society Grand Duke Nikolai Mikhailovich Romanov to collect materials for the publication of four volumes of the "Russian Provincial Necropolis". It analyses the contribution of Vilna, Minsk, Mogilev, Grodno, Polotsk consistories as well as priests of the Belarusian dioceses in collection of epitaphs from the tombstones of clerics, nobles and the most prominent public figures of the Russian Empire (partially the Grand Duchy of Lithuania, the Polish-Lithuanian Commonwealth) for the publication of the 4th volume of the "Russian Provincial Necropolis". An analysis of the biographies of the deceased was carried out, and their activities are correlated with the events of the history of Belarus of the XV - early XX century.

Demographic and Socio-Political Aspects of the International Project “Dialogue Partnership”

The review of selected works by Larisa S. Ruban in five volumes presents an analysis of the research within the framework of the project “Dialogue partnership as a factor of stability and integration”. The 1st volume “Migration and Demography” focuses on the study of forced migration in the post-Soviet space, its causes and consequences, the directions and composition of migration flows that have largely changed the host regions. The 2nd volume “Sociology and Conflictology” presents the results of a longitudinal study in 12 regions, characterizing the formation of civic consciousness of three generations of young people: the last Soviet, transitional period and the first post-Soviet generation. Also, the 2nd volume outlines the author’s theory of the triad of political deviation. The 3rd volume “International Relations, Geopolitics and Globalistics” is based on the results of international expert surveys on the situation in 16 countries of the Asia-Pacific region in the political sphere, economy and security in order to determine effective areas for cooperation between the Russian Federation and Asian countries in the new conditions. The topic of the 4th volume “Energy, innovation and digitalization” reflects the decisive influence of energy on the development of production and social spheres, and the turn of Russia’s energy policy to the East. The 5th volume “Security and Counter-Terrorism” presents the research by Professor L. S. Ruban on global and regional security and counter-terrorism, a hot topic of our time, when the Russian Federation has to resist the sanctions of the collective West, while close interaction with China generally strengthens the position of Russia.

Microchimerism in multiple sclerosis: The association between sex of offspring and MRI features in women with multiple sclerosis.

During pregnancy, fetal cells can migrate to the mother via blood circulation. A percentage of these cells survive in maternal tissues for decades generating a population of fetal microchimeric cells (fMCs), whose biological role is unclear. The aim of this study was to investigate the association between the sex of offspring, an indirect marker of fMCs, and magnetic resonance imaging (MRI) features in women with multiple sclerosis (MS). We recruited 26 nulliparous MS patients (NPp), 20 patients with at least one male son (XYp), and 8 patients with only daughters (XXp). Each patient underwent brain MR scan to acquire 3D-T2w FLAIR FatSat and 3D-T1w FSPGR/TFE. Lesion Segmentation Tool (LST) and FreeSurfer were used to obtain quantitative data from MRI. Additional data were collected using medical records. Multiple regression models were applied to evaluate the association between sex of offspring and MS data. Comparing NPp and XXp, we found that NPp had larger 4th ventricle volume (2.02 ± 0.59 vs. 1.70 ± 0.41; p = 0.022), smaller left entorhinal volume (0.55 ± 0.17 vs. 0.68 ± 0.25; p = 0.028), and lower thickness in the following cortical areas: left paracentral (2.34 ± 0.16 vs. 2.39 ± 0.17; p = 0.043), left precuneus (2.27 ± 0.11 vs. 2.34 ± 0.16; p = 0.046), right lateral occipital (2.14 ± 0.11 vs. 2.25 ± 0.08; p = 0.006). NPp also had lower thickness in left paracentral cortex (2.34 ± 0.16 vs. 2.46 ± 0.17; p = 0.004), left precalcarine cortex (1.64 ± 0.14 vs. 1.72 ± 0.12; p = 0.041), and right paracentral cortex (2.34 ± 0.17 vs. 2.42 ± 0.14; p = 0.015) when compared to XYp. Comparing XYp and XXp, we found that XYp had higher thickness in left cuneus (1.80 ± 0.14 vs. 1.93 ± 0.10; p = 0.042) and left pericalcarine areas (1.59 ± 0.19 vs. 1.72 ± 0.12; p = 0.032) and lower thickness in right lateral occipital cortex (2.25 ± 0.08 vs. 2.18 ± 0.13; p = 0.027). Our findings suggested an association between the sex of offspring and brain atrophy. Considering the sex of offspring as an indirect marker of fMCs, we speculated that fMCs could accumulate in different brain areas modulating MS neuropathological processes.

Editorial

Every time through our Journal we try to present a collection of research papers and studies that bring to the light a new ambit of Yagya research. With a similar aim, another attempt has been made to bring an assortment of some interesting works in this 4th Volume 2nd Issue of the Dev Sanskriti Interdisciplinary Journal of Yagya Research (IJYR). This issue caters to a wide spectrum of Yagya research which includes application of Yagya in tourism, scientific evaluation of the ancient practice of Balivaishva Yagya, importance and use of herbal fumes. All of these try to integrate science and spirituality at their level.
 The first research article of this issue deals with the study of Balivaishva Yagya its significance and importance in daily life. The author Harsika Jaiswal, investigated the meaning, philosophy, procedure, and utility of Balivaishva Yagya in the present time. She concluded that the five inspirations and messages are hidden in Balivaishva Yagya which can create a spiritual environment in the family as well as solve all the problems of the individual and the world – opening door to all-rounded progress by uprising divine culture in society.
 
 The second research paper explores the applications of Yagya in tourism. The author Prachi Agarwal, Arunesh Parashar investigated the Development of Holistic Religious Tourism through the Ancient Indian Technique of Yagya. In their study, they concluded that the Ashwamedha Yagya can act as an important component of religious tourism and gives a newer dimension to religious tourism by providing holistic development of the participants at religious sites through Ashwamedha for national unity, peace, and harmony.
 The third research article explores the importance and uses of herbal fumes. The author Lalima Batham has investigated the Indian scriptures and Veda in the context of Yagya and reported that herbal fumes produced in the process of Yagya hold high medicinal properties and can be included in Ayurvedic therapy. The next research article states about the cosmic Yagya which implies that human life is sacrificial life (Yagyamay Jeevan - यज्ञमय जीवन). The author Akanksha Prajapati concluded that Yagya is not just a physical process but a lifestyle to live.
 Lastly, under the guidance of Honorable Dr. Chinmay Pandya, Pro Vice Chancellor, DSVV has organized a symposium on “Advancement of Research on Yagya” in which renowned scientists from various research institutes like IITs (Indian Institute of Technology), National Environmental Engineering Research Institute (NEERI)-Nagpur, National Physical Laboratory-CSIR, and many others. They presented their study and view on the same. The discussion has been manuscript and presented in the last paper as Consensus of the symposium. 
 We hope this issue will inspire and generate interest among researchers, educators, tour planners, and professionals to understand the significance of the indigenous knowledge of Yagya in the present era. We would also like to thank all our readers and request them to send us their valuable feedback to make this journal a more effective vehicle of indigenous knowledge in the future.

Topical Use of Saussurea costus (Falc.) Lipsch. (Qost) Oil in Pediatric Nocturnal Enuresis in Comparison with Sesame Oil, A Randomized Double-Blind Clinical Trial

Nocturnal enuresis is one of the most common chronic problems of childhood. It has a significant effect on health and quality of life of children and their families. Despite pharmacological treatments, enuresis in most children relapses after the medication is discontinued. Also available drugs have many side effects that limited their uses. So, we compared the effect of topical use of Saussurea costus (Falc.) Lipsch. (Qost) oil as a Persian Medicine product on pediatric nocturnal enuresis in a parallel randomized double blinded study. Eighty-two patients aged 5 to 15 years who were diagnosed as monosymptomatic nocturnal enuresis were allocated to receive costus oil or sesame oil topically below the navel twice a day for 4 weeks. Patients were evaluated prior to and following end of the study in terms of frequency of enuresis and any observed adverse events. The results were evaluated with valid PLUTSS questionnaire. For evaluation, Chi-square and Fisher's exact tests, Mann-Whitney and Wilcoxon tests were used. Significant p value was < 0.05. A significant decrease in mean scores of the questionnaires was noted in both groups. The results before and after the intervention were significantly different in both groups, but there was no statistically significant difference between the intervention and control groups. At the end of the 4th week, the frequency and volume of enuresis showed a 46.2 percent reduction in costus oil group and a 25.5 percent reduction in sesame oil group. According to this study, the response rate based on PLUTSS questionnaire in costus oil group is 74.5%; while in the sesame oil group is 69%. No drug side effect was noticed in this study. Based on the results of this study, costus oil is effective in children with monosymptomatic nocturnal enuresis; however, there is no significant difference between costus oil and sesame oil.

The Early Estampages of the Tonyukuk Inscription Identified in the Collection of Central Asia and Siberia of the IOM, RAS

The Tonyukuk inscription, also known as the Bain Tsokto monument, was discovered by Elizaveta Klementz not far from the city of Urga (modern Ulaanbaatar) in 1897. The text was published two years later by a prominent Russian researcher Wilhelm Radloff. At the same time 17 photographs of estampages were included in the 4th volume of the “Atlas der Alterthümer der Mongolei”. While these photo copies are still frequently mentioned in the multiple publications concerning the Tonyukuk inscription, only a few specialists are aware that the originals are kept in the Collection of Central Asia and Siberia of the IOM, RAS. Moreover 81 estampages were identified as copies of the Tonyukuk inscription during the full-scale inventory of the Collection that took place in 2021. Thanks to recent publications by V. Tishin, it became obvious that eight similar copies of the monument are preserved in the collection of the Academician Obruchev Museum of Local Lore (Kyakhta). This discovery allowed to specify the authorship and dating of the St. Petersburg copies. The Chinese seal preserved on one of the Khyakhta’s estampages suggests that they were produced for the last Qing Amban of Outer Mongolia Sanduo between 1910 and 1911. Although the monument has been well studied, some of the preserved at the IOM copies seem to be of great value and could be used by turcologists for controversial text fragments clarification. The paper presents acquisition history and brief description (catalogue) of the preserved copies of text.

Loss and gain in the Vietnamese translational equivalents of English idioms used in the 4th volume of the novel series “Harry Potter” by J.K. Rowling

Owning to their unique semantic and structural features, idioms contribute to the richness of language, enabling language users to express their ideas in concise and sophisticated ways. This study is aimed at identifying and analyzing loss and gain in the Vietnamese translational equivalents of the English idioms used in the 4th volume of the Harry Potter novel serial by J.K. Rowling. The translation shift theory of Catford [1], [2] was employed to clarify the fundamental aspects of loss and gain phenomena. The study reveals that loss and gain in lexis or structure occur frequently in translations of idioms, assisting in preserving the idioms’ figurative meanings. It is hoped that the research results can be of some help for teaching, learning and English – Vietnamese translation of idioms.

From The Editor

Welcome to the 4th Volume, 1st Issue of Health Education in Practice: Journal of Research for Professional Learning. We have a very interesting series of articles in this volume.

Матеріялы до руского словаря – rękopiśmienny dziewiętnastowieczny słownik ukraińsko-polski Josyfa Skomorowskiego

Матеріялы до руского словаря – the Ukrainian-Polish manuscript dictionary by Josyf Skomorovski – consists of 5 volumes and 1732 pages. It was probably completed in 1849. The register of the Ukrainian dictionary has 27000 entries. In the Ukrainian part, there is a lot of phonetic and lexical polonisms as well as dialectical lexical items. Some Ukrainian dictionary entries were not translated – especially in the 4th volume. Some of the Ukrainian words were presented in two orthographical variants – Skomorowski initially tried to follow the rules of phonetic orthography, but then he verified the Ukrainian part in accordance with the etimological orthography. The dictionary is not free from translation errors, it also includes some Ukrainian lexicon which has not been confirmed in other sources.

Characteristic of Teaching Materials for Arabic Reading Skill with Inductive Approach

Himmati is deliberately created as a textbook modification to recognize the Qur'an prepared for beginners. This research aimed to describe the characteristics of teaching material contained in Himmati. This research was a qualitative approach and content analysis of the perspective of Thu’aimah. It also belonged to library research with the main data source is a book, named Himmati: Modifikasi Pembelajaran Dasar Mengenali al-Qur’an from volume 1 to volume 5. The results showed that: 1) Generally, the teaching materials in Himmati were divided into 5 volumes which were presented inductively, namely the introduction of letters, words, tajweed, gharib, and verses in the Qur’an. Specifically, the teaching materials in Himmati were divided into 7 volumes which were presented with examples from the Qur'an and colored in the order of the frequency of visible light, from red to violet. The 1st volume focused on pronunciation, the 2ndA volume was on short vowels, long vowels, nunation (tanwin), and original sukuun, the 2ndB volume was on non-original sukuun and shadda, the 3rdA volume was on the law of nuun sukuun, nunation, germination nuun and miim, the 3rdB volume was on the law of miim sukuun, definite article al, and madd, the 4th volume was on the rule of exception, and the 5th volume was on the stop sign. The teaching materials in Himmati presented for beginners level

Codex Diplomaticus Maritimus Croatiae/Croatian Diplomatic Maritime Codex and the Croatian Maritime Regesta, vol. 4: Emerging project

This paper presents an outline and announces the continuation of the Codex Diplomaticus Maritimus Croatiae (Croatian Diplomatic Maritime Codex), consisting of a total of 100,000 documents on Croatia’s presence in the Adriatic and the Mediterranean. Nikola Čolak had started this project in 1956 in Zadar and was developing it for the next 40 years, exploring all the relevant archives on both coasts of the Adriatic that were relevant for not only Croatian history but for everyone else participating in this trade (Italians, Jews, and many others). After the 3rd volume of the Croatian Maritime Regesta was published in 2017, two historians decided to continue, in collaboration with other Croatian and foreign researchers, the publication of the aforementioned series by publishing the 4th volume of this series. The project introduces, as the innovation to the original project, the use of modern technologies related to the processing of digitized data as to allow everyone free access to hitherto unpublished archival sources in regesto as well as in extenso, depending on the importance of the document.

Поль Рикёр о совместном бытии людей (по страницам книги “Paul Ricoeur. Politique, économie et société. Écrits et conférences 4” (Paris, 2019))

The 4th volume of “Manuscripts and Speeches” by the prominent contemporary thinker Paul Ricoeur (1913‑2005) contains works discussing one of his central themes — the problem of a common existence of men considered from the point of view of politics, economics, power, law, culture, morality, and ethics. At the same time, the French thinker specifically highlights and discusses such burning problems of modern life as mutual recognition, the fragility of human existence and earthly civilization in general, tolerance, care, justice, responsibility for the future of humanity, for the very idea of man. In a number of works, Ricoeur expresses his views on the possible future of Europe — on its new ethos overcoming the boundaries and structures of national states, on the combination of their “identity” and “otherness” at the global level. Translation from one language to another as a kind of a priori communication, exchange of memory as a preliminary transfer to a different cultural environment, forgiveness that stems from the suffering of others and raises the question of the burden of debt, — all this is being considered as a models of integration. Originally presented at philosophical congresses and symposia, as well as qua journal publications, the highlighted problems were fundamentally studied by the philosopher in his works “History and Truth” (1955), “Oneself as Another” (1990), “Ethics and Responsibility” (1994), “The Just” (vols. 1, 2 — 1995, 2001), “Ideology and Utopia” (1997), “Memory, History, Oblivion” (2000), “The Way of Recognition” (2004). The book “Paul Ricoeur. Politics, Economics and Society. Manuscripts and Speeches 4” is addressed to philosophers, cultural and political scientists and scholars representing different branches of humanitarian studies, as well as to readers interested in contemporary philosophy.

Multiparametric cerebellar imaging and clinical phenotype in childhood ataxia telangiectasia.

Ataxia Telangiectasia (A-T) is an inherited multisystem disorder with cerebellar neurodegeneration. The relationships between imaging metrics of cerebellar health and neurological function across childhood in A-T are unknown, but may be important for determining timing and impact of therapeutic interventions. To test the hypothesis that abnormalities of cerebellar structure, physiology and cellular health occur in childhood A-T and correlate with neurological disability, we performed multiparametric cerebellar MRI and establish associations with disease status in childhood A-T. Prospective cross-sectional observational study. 22 young people (9 females / 13 males, age 6.6-17.8 years) with A-T and 24 matched healthy controls underwent 3-Tesla MRI with volumetric, diffusion and proton spectroscopic acquisitions. Participants with A-T underwent structured neurological assessment, and expression / activity of ataxia-telangiectasia mutated (ATM) kinase were recorded. Ataxia-telangiectasia participants had cerebellar volume loss (fractional total cerebellar volume: 5.3% vs 8.7%, P<0.0005, fractional 4th ventricular volumes: 0.19% vs 0.13%, P<0.0005), that progressed with age (fractional cerebellar volumes, r=-0.66, P=0.001), different from the control group (t=-4.88, P<0.0005). The relationship between cerebellar volume and age was similar for A-T participants with absent ATM kinase production and those producing non-functioning ATM kinase. Markers of cerebellar white matter injury were elevated in ataxia-telangiectasia vs controls (apparent diffusion coefficient: 0.89×10-3mm2s-1 vs 0.69×10-3mm2s-1, p<0.0005) and correlated (age-corrected) with neurometabolite ratios indicating impaired neuronal viability (N-acetylaspartate:creatine r=-0.70, P<0.001); gliosis (inositol:creatine r=0.50, P=0.018; combined glutamine/glutamate:creatine r=-0.55, P=0.008) and increased myelin turnover (choline:creatine r=0.68, P<0.001). Fractional 4th ventricular volume was the only variable retained in the regression model predicting neurological function (adjusted r2=0.29, P=0.015). Quantitative MRI demonstrates cerebellar abnormalities in children with A-T, providing non-invasive measures of progressive cerebellar injury and markers reflecting neurological status. These MRI metrics may be of value in determining timing and impact of interventions aimed at altering the natural history of A-T.

Editorial Foreword

We are very pleased that Idealogy Journal of Arts and Social Science is presenting its 4th volume and 2nd issue. We are also very excited that the journal has been attracting papers from a variety of advanced and emerging countries such as Indonesia, Pakistan, Saudi Arabia, Bangladesh, etc. The variety of submissions from such countries will help the aimed global initiatives of the journal. We are also delighted that the researchers from the Arts and Social Science fields demonstrate an interest to share their research with the readers of this journal. This issue of Journal of Arts and Social Science contains five outstanding articles which shed light on contemporary research questions in arts and social science fields

Travelling notes by Pyotr Pertsov during his European travel, May to June, 1913 (according to letters to Mariya Pertsova)

In the article the author carried out reconstruction of an episode from life of P.P. Pertsov communicated by the most prominent figures of the Fin de siècle (Dmitry Merezhkovsky and Zinaida Gippius, Alexander Block, Valery Bryusov, Vasily Rozanov, Sergey Durylin etc.). The scientific value of this article consists in reproduction of an episode from life of Pyotr Pertsov based on the archive materials, which never before were not published that defined lack of references to any researches. Pyotr Pertsov’s biography in general reproduced by the academician Aleksandr Lavrov in the 4th volume of the Russian Writers dictionary, needs specifications and additions which in this case, become on the basis of a research Pyotr Pertsov’s epistolyary and his partial publication. All data on the research connected with Pyotr Pertsov’s biography are presented by the author of article in Notes and the List of references. The specifics of the article were defined by a biography genre, what the name of the article confirms. On the basis by Pyotr Pertsov’s letters to his wife, Mariya Pertsova, their retelling and the partial publication its travel across Germany and Austria from May to June, 1913, is reproduced. Atention is paid to Pyotr Pertsov’s attitude towards the wife, specifics of his perception of the European culture and the nature, reminiscence of the Russian literature. As conclusions as result of Pyotr Pertsov's trip, the list of articles, which are written and published by him under the impression of the trip is given. As the author of the article belives, a similar conclusion corresponds to a biography genre, reveals that during the trip, Pyotr Pertsov actively worked as a journalist.

A Review on the 4th Volume of a Compilation of Papers «Evolution of Russian and Foreign State and Law. Towards the 80 Years Anniversary of the History of State and Law Chair of the Ural State Law University (1936–2016)»

A Review on the 4th Volume of a Compilation of Papers «Evolution of Russian and Foreign State and Law. Towards the 80 Years Anniversary of the History of State and Law Chair of the Ural State Law University (1936–2016)»

Effects of Low-Intensity Pulsed Ultrasound on Implant Osseointegration in Ovariectomized Rats.

To investigate the effect of low-intensity pulsed ultrasound (US) on peri-implant bone healing and osseointegration under osteoporotic conditions. Seventy-two 12-week-old female Sprague Dawley rats received bilateral ovariectomies. Twelve weeks later, titanium implants were bilaterally placed in the proximal tibial metaphysis. The right tibia was exposed to low-intensity pulsed US (40 mW/cm2 , spatial and temporal average) for 20 min/d starting the 2nd day after implantation, and the left tibia served as a control without stimulation. The rats were randomly assigned to 6 groups of 12 each according to the US duration (group 1: weeks 0-2, 280 minutes; group 2: weeks 0-4, 560 minutes; group 3: weeks 0-6, 840 minutes; group 4: weeks 0-8, 1120 minutes; group 5: weeks 0-10, 1400 minutes; group 6: weeks 0-12, 1680 minutes). At the end of the 2nd, 4th, 6th, 8th, 10th, and 12th weeks, the rats were euthanized, and bilateral tibias were harvested. Peri-implant bone volume and bone-implant contact were assessed by micro-computed tomography; the implant-bone interface was assessed histologically; and implant fixation strength was determined by a removal torque test. Low-intensity pulsed US increased bone-implant contact at the 4th, 6th, 8th, 10th, and 12th weeks (P = .019, .017, <.001, <.001, and <.001, respectively) and peri-implant bone volume at all times (P = <.001, .002, .012, .007, .005, and .010). Removal torque on the US side was improved at the 6th, 8th, 10th, and 12th weeks (P= .012, <.001, .006, and .009). Ultrasound evoked a favorable bone response in the histologic study. Low-intensity pulsed US might enhance new bone formation, especially at an early stage, and improve osseointegration in osteoporotic bone as an auxiliary method. However, further studies are needed to elucidate the mechanisms underlying its action.