Last-mile delivery of health commodities is a critical component of efficient supply chains, and third-party logistics (3PL) providers are pivotal in ensuring cost-effective and reliable product distribution. This study explores the implementation of last-mile delivery outsourcing by government-operated warehouses and drug management agencies (DMAs). This research focuses on the relationship between 3PL utilization and key performance metrics, such as cost reduction, timely delivery, and end-user satisfaction. This study combines a literature review, surveys, and interviews conducted with employees of the DMAs in Minna, Niger State, to establish significant correlations. The findings show that using 3PLs significantly reduced operational costs, improved the frequency of timely deliveries, and enhanced end-user satisfaction. These findings underscore the need for continued engagement with 3PL providers to optimize supply chain performance and improve service delivery outcomes. Managers are recommended to maintain and expand such collaborations to sustain these benefits.