Motion disease (naupathia, seasickness) is quite prevalent among otherwise healthy people and is manifested as travel sickness associated with nausea. It is a complex physiological response to certain motor stimuli caused by ship rocking, aircraft swinging or zero gravity. The motor stimuli may be both real (ship rocking) and virtual (watching a 3D movie). During the last decade, numerous studies addressed different stimuli that can cause naupathia, and numerous hypotheses have been put forward to explain it (sensory conflict, postural instability etc.) from the point of view of neural plasticity. However, no consensus concerning the origin of the specific clinical pattern of naupathia (nausea, vomiting, drowsiness, dysphoria etc.) has emerged by now. Several drugs and behavioral recommendations have been suggested for prevention and treatment of naupathia. Further studies of this condition using such techniques as videonystagmography and computer-assisted posturegraphy, as well as genetic analysis, are warranted.