4-aminophenylacetic Acid Research Articles

Synthesis, characterization and bioactive evaluation of cobalt(II) and copper(II) complexes of {4-[5-(5-sulfanylidene-2,5-dihydro-1H-1,2,4-triazol-3-yl) furan-2-yl] phenyl} acetic acid

A new triazole derivative was synthesized by three steps. The first step involve adding 2-carboxyaledhyed furan to the 4-amino phenyl acetic acid after converting the substituted aromatic amine to the diazanium salt. In the first stage, [4-(5-formylfuran-2-yl) phenyl] acetic acid is the title of product. The second step is adding the thiosemicarbazide to the [4-(5-formylfuran-2-yl) phenyl] acetic acid which it gives the (4-{5-[(2-carbamothioylhydrazinylidene) methyl] furan-2-yl} phenyl) acetic acid. A final compound with the title {4-[5-(15-sulfanylidene-2,5-dihydro-1H-1,32,4-triazol-3-yl) furan-22-yl] phenyl} acetic acid was produced as a result of adding sodium acetate and chloro ethyl acetate to the product from the second step in the presence of triethyl amine which is used as a ligand to prepare cobalt(II) and copper(II) complexes. The structures of synthesized compounds were identified through the utilization of diverse measures, these measurements were (UV-Vis spectrum, LC-MS technique, FT-IR spectrophotometer, conductivity measurements, GC-mass spectra and atomic absorption) and melting point measurement. The results confirmed that the complexes have octahedral geometry. The biological activity data for the synthesized compounds revealed that the ligand and its complexes had antibacterial activity. KEY WORDS: Synthesis, Triazole derivatives, Cobalt(II) complex, Copper(II) complex, Biological evaluation Bull. Chem. Soc. Ethiop. 2024, 38(6), 1595-1607. DOI: https://dx.doi.org/10.4314/bcse.v38i6.8

Novel cellulose derivative containing aminophenylacetic acid as sustainable adsorbent for removal of cationic and anionic dyes

The synthesis and characterization of a novel cellulose derivative as a potential sustainable adsorbent for cationic and anionic dyes are described through processing in ionic liquids. Cellulose was solubilized in ionic liquid with tosyl chloride to form tosyl cellulose which reacted with 4-aminophenylacetic acid through nucleophilic substitution mechanism. The new cellulose derivative was characterized and explored as an effective adsorbent for methylene blue (MB) and methyl orange (MO) removal, and the adsorption behaviors were investigated with various models. The adsorption behavior of the cellulose derivative followed Langmuir and pseudo-second-order models, and the maximum adsorption efficiency recorded 135 and 106 mg/g for MB and MO, respectively. There is possibility that the enhanced adsorption capacity of the cellulose derivative is due to the carboxylic and amino functional groups that provide sufficient active sites to enhance dye molecule affinity. The adsorption results demonstrate that the cellulose derivative containing aminophenylacetic acid was efficient adsorbent for removals of MB and MO.

Chemical constituents and their α-glucosidase inhibitory activities of seeds of Moringa oleifera

The chemical constituents of the seeds of Moringa oleifera were isolated and purified by using Sephadex LH-20, Toyo-pearl HW-40F, silica gel, ODS, and MCI column chromatography. The structures of compounds were identified by high-resolution mass spectrometry, ~1H-NMR, ~(13)C-NMR, HMQC, HMBC, and ~1H-~1H COSY, as well as physicochemical properties of compounds and literature data. Twelve compounds were isolated from 30% ethanol fraction of the seeds of M. oleifera and identified as ethyl-4-O-α-L-rhamnosyl-α-L-rhamnoside(1), ethyl-3-O-α-L-rhamnosyl-α-L-rhamnoside(2),(4-hydroxybenzyl)ethyl carbamate(3),(4-aminophenyl)acetic acid(4), ethyl-α-L-rhamnoside(5), methyl-α-L-rhamnoside(6), moringapyranosyl(7), 2-[4-(α-L-rhamnosyl)phenyl]methyl acetate(8), niaziridin(9), 5-hydroxymethyl furfural(10), 4-hydroxybenzeneacetamide(11), and 4-hydroxybenzoic acid(12). Among them, compounds 1 and 2 are two new compounds, compound 3 is a new natural product, and compounds 4-5 were yielded from Moringa plant for the first time. All compounds were evaluated for α-glucosidase inhibitory activity in vitro. Compound 10 showed excellent inhibitory activity with IC_(50) of 210 μg·mL~(-1).

Experimental study of the transformation of 2-aminophenylacetic acid hexafluorosilicate into 2-oxindol under mild conditions

Currently, ammonium hexafluorosilicates are being actively studied as new anti-caries agents, which, according to the results of researches on rats, show a more significant caries-preventive effectiveness compared to sodium fluoride with a simultaneous significant improvement of the biochemical indicators of the dental pulp and the absence of hepatotoxic effects. Previously, we’ve synthesized 2-, 3-, 4-aminophenylacetic acid hexafluorosilicates (2-, 3-, 4-APhHFS); in an attempt to recrystallize the 2-APhHFS salt from ethanol, a red crystalline product was obtained.
 The purpose of the research – considering the potential prospects of 2-, 3-, 4-APhHFS, it is expedient to establish the composition and structure of the recrystallization product of 2-APhHFS. Mass spectra were recorded on MX-1321 and VG 7070 spectrometers (VG Analytical), X-ray structural analysis was carried out on an Xcalibur E diffractometer.
 As follows from the comparison of the external inspection of the original 2-APhHFS and its recrystallization product (RP) samples, they differ significantly: light brown amorphous 2-APhHFS and red crystalline RP. The characteristics of the mass spectra of 2-APhHFS and RP are also different. The structure of RP as 2-oxindole was objectively established by X-ray diffraction data.
 The recrystallization process of 2-APhHFS to obtain 2-oxindole does not require heating of the reaction mixture, i.e., it is carried out under extremely mild conditions. It is possible that it's connected with the participation of the protonated form of 2-aminophenylacetic acid in the composition of 2-APhHFS in chemical transformations.
 Thus, caution should be exercised in experiments with both solutions and, apparently, solid samples of 2-APhHFS during salt purification procedures or other manipulations. The high lability of 2-aminophenylacetic acid hexafluorosilicate limits the possibilities of using standard purification methods (sublimation, recrystallization) for this compound.

One-Step Formation of Pharmaceuticals Having a Phenylacetic Acid Core Using Water Microdroplets.

The properties of water microdroplets strikingly differ from bulk water. Using room-temperature water microdroplets, we find that toluene can react with CO2 to form phenylacetic acid in one step without any catalyst with negative high voltage applied at the sprayer source. The chemical components of these microdroplets are identified by mass spectrometry, and product structures are confirmed by tandem mass spectrometry. In this manner, we generate three drug molecules in a single step: 4-aminophenylacetic acid (epithelial peptide transporter PepT1 inhibitor), 3,4-dihydroxyphenylacetic acid (dopamine metabolite neurotransmitter), and phenylacetic acid (sodium salt form; treatment of urea cycle disorder). Mechanistic studies show that benzyl radicals formed from hydroxyl radicals at the water microdroplet interface drive these carboxylation reactions. This water microdroplet chemistry is general, allowing activation and subsequent carboxylation of aryl α-C-H groups.

Disposable electrochemical sensor based on ion imprinted polymeric receptor for Cd(II) ion monitoring in waters

Cadmium is a highly toxic heavy metal, even at low concentrations. Moreover, it bio-accumulates with a long biological half-life producing a wide variety of acute and chronic effects like cancer in humans. Therefore, there is significant interest in providing a portable and user-friendly sensor for heavy metal detection. A highly sensitive and selective electrochemical sensor for Cd(II) determination was developed as an alternative. The Cd (II) receptors were integrated into the sensor using an ion-imprinted polymer film (IIPs film). Accordingly, 4-aminophenylacetic acid (4-APA) was electropolymerised in the presence of Cd(II) ions as a template using cyclic voltammetry (CV) on screen-printed carbon electrodes (SPCEs). Imprinted cavities were obtained after the alkaline elution of ions. Sensor characterisation was performed using SEM, ATR-FTIR and electrochemical methods, such as cyclic voltammetry (CV) and electrochemical Impedance Spectroscopy (EIS), and compared to control experiments (not imprinted polymeric film, NIP film). Analytical performances of the IIP sensor revealed a sensitivity 5-order of magnitude higher than the NIP response in a concentration range from 10 to 1200 nM of Cd (II). This technology can potentially be applied for water quality control and monitoring of heavy metals.

Synthesis, Structural Elucidation, and Biological Potential of Novel Sulfonamide Drugs

Sulfonamides are anti-microbial and anti-inflammatory agents used widely for the treatment of infections. The current research dealt with the synthesis of four sulfonamides formed by the reaction of p-toluenesulfonyl chloride with 4-amino phenyl acetic acid, 5-amino isophthalic acid, 4-piperidine carboxylic acid, and toluidine. The respective structures of sulfonamide drugs were verified by elemental analysis (CHNS), FT-IR spectroscopy, and thermogravimetry. The elemental analysis (CHNS) data conformed to the proposed chemical composition of the products 1-4. The FT-IR spectra verified the formation of sulfonamide drugs. Thermogravimetric analysis (TGA) of data in the range of 25-800oC showed that the evolved components and residues were in good agreement with the molecular skeletons of the products. The antibacterial potential of sulfonamide drugs was evaluated against bacterial strains using the disc diffusion method. The zones of inhibition were found to be larger against Escherichia coli as compared to Bacillus Subtilis. Cytotoxicity of products was in the acceptable range of 0.3-3.1%, as compared to triton X100. It indicates the safety of these products as future medicinal drugs for human beings.

Mathematical Modelling of Glyphosate Molecularly Imprinted Polymer-Based Microsensor with Multiple Phenomena.

The massive and careless use of glyphosate (GLY) in agricultural production raises many questions regarding environmental pollution and health risks, it is then important to develop simple methods to detect it. Electrochemical impedance spectroscopy (EIS) is an effective analytical tool for characterizing properties at the electrode/electrolyte interface. It is useful as an analytical procedure, but it can also help in the interpretation of the involved fundamental electrochemical and electronic processes. In this study, the impedance data obtained experimentally for a microsensor based on molecularly imprinted chitosan graft on 4-aminophenylacetic acid for the detection of glyphosate was analyzed using an exact mathematical model based on physical theories. The procedure for modeling experimental responses is well explained. The analysis of the observed impedance response leads to estimations of the microscopic parameters linked to the faradic and capacitive current. The interaction of glyphosate molecules with the imprinted sites of the CS-MIPs film is observed in the high frequency range. The relative variation of the charge transfer resistance is proportional to the log of the concentration of glyphosate. The capacitance decreases as the concentration of glyphosate increases, which is explained by the discharging of the charged imprinted sites when the glyphosate molecule interacts with the imprinted sites through electrostatic interactions. The phenomenon of adsorption of the ions in the CMA film is observed in the low frequency range, this phenomenon being balanced by the electrostatic interaction of glyphosate with the imprinted sites in the CS-MIPs film.

Synthesis, characterization, X-ray crystal structures and antibacterial properties of cobaloximes with aniline based ligands containing acid functionality

Cobaloximes of the type [Co(X)(dmgH)2B], where dmgH = Dimethylglyoxime monoanion, X = Cl−, Br−, SCN− and B = 4-Aminophenylacetic acid (4-APAA) and4-Aminobenzoic acid (4-ABA), have been synthesized. Better yield was obtained when bromide ion was used as an axial ligand. The synthesized cobaloximes were characterized by IR, UV spectroscopy and cyclic voltammetry. The structures of the two cobaloximes [Co(Cl)(dmgH)2(4-ABA)] and [Co(Br)(dmgH)2(4-ABA)] have been characterized by X-ray Crystallography. The complexes were screened for their antibacterial activity against gram positive Methicillin Resistant Staphylococcus aureus (MRSA) MTCC 1430 and gram negative Acinetobacter baumannii MTCC 1425 bacteria using Agar well diffusion method, Tube method and Biofilm eradication on biomaterial methods. It has been found that all the cobaloxime complexes exhibited inhibition against both the test microorganisms. Cobaloximes have been found to be more active against the gram negative bacteria compared to gram positive bacteria.

Biosynthesis of actarit using engineered Escherichia coli

Actarit is widely regarded as a safe and effective drug for the treatment of rheumatoid arthritis. There is no report on the bioproductin of actarit so far. In this study, we demonstrated for the first time the development of an artificial actarit biosynthetic pathway in Escherichia coli. First, 4-aminophenylacetic acid is selected as precursor substrates for the production of actarit. Second, an N-acetyltransferase that can efficiently catalyse the esterification of acetyl-CoA and 4-aminophenylacetic acid to form actarit was discovered. Subsequently, an engineered E. coli that allows production of actarit from simple carbon sources was established. Finally, we further increased the production of actarit to 206 ± 16.9 mg/L by overexpression of shikimate dehydrogenase ydiB and shikimate kinase aroK.

Electrochemical Impedance Spectroscopy Microsensor Based on Molecularly Imprinted Chitosan Film Grafted on a 4-Aminophenylacetic Acid (CMA) Modified Gold Electrode, for the Sensitive Detection of Glyphosate.

A novel electrochemical impedance spectroscopy (EIS) microsensor was implemented for the dosage of traces of glyphosate, in real and synthetic water samples. Molecularly imprinted chitosan was covalently immobilized on the surface of the microelectrode previously modified with 4-aminophenylacetic acid (CMA). The characterization of the resulting microelectrodes was carried out by using cyclic voltammetry measurement (CV), scanning electron microscopy (SEM), and electrochemical impedance spectrometry (EIS). EIS responses of the CS-MIPs/CMA/Au microsensor toward GLY was well-proportional to the concentration in the range from 0.31 × 10−9 to 50 × 10−6 mg/mL indicating a good correlation. The detection limit of GLY was 1 fg/mL (S/N = 3). Moreover, this microsensor showed good reproducibility and repeatability, high selectivity, and can be used for the detection of GLY in river water.

Synthesis, characterization, and activity of 6-(10H-phenothiazine-10-yl)-1H,3H-benzo[de]-isochromen-1,3-dione derivative of 4-aminophenylacetic acid

The objective of the present paper was to study the synthesis of a new compound 6-(10H-phenothiazme-10-yl)-1H,3H-benzo[de]-isochromen-1,3-dione derivative of 4-aminophenylacetic acid (PTZD). Its physicochemical characteristics and spectral data were presented. PTZD was found to have good inhibitory activity. The phenothiazine derivative showed good fungicidal activity against the studied yeast (S. cerevisiae and C. albicans) and mold species (A. brasiliensis and F. moniliforme), weak bactericidal activity against the Gram-positive bacteria S. aureus and B. subtilis and did not affect the growth of Gram-negative bacteria E. coli, P. aeruginosa and S. abony.

S3183 Effect of Azo Bonded 5-ASA and 4-APAA on DNBS-Induced Colitis in Rats

INTRODUCTION: Azo chemistry, enables drug delivery to the colon, where bacterial azo reductases can cleave the bond, liberating the two moieties. In all commercial IBD azo preparations, the only active moiety is 5-ASA, an anti-inflammatory agent. Delivering two different active moieties such as anti-inflammatory and an immunomodulator may improve efficacy. 4-aminophenylacetic acid (4-APAA), has been used in Japan for the past 10 years in the treatment of Rheumatoid Arthritis. It has an available amino group for azo bonding. 4-APAA is known to reduce TNF-α, IL-1β, MMP-1 production and to reduce the adhesion of T cells. We herein report the effect of azo bonded 5-ASA + 4-APAA on experimental colitis in rats. METHODS: Experimental colitis—on Day 0, a catheter was inserted rectally into the colon and the irritant, an ethanolic solution of 2,4 dinitrobenzenesulfonic acid (DNBS) was instilled at a volume of 0.5 mL. Concentration of DNBS was 60 mg/mL in 30% ethanol for a total dose of 30 mg DNBS. Animals—30 adult male Lewis rats (weighting 200–250 g) were divided into 5 groups of 6 animals each: (1) Vehicle; (2) Vehicle + DNBS; (3) 5-ASA 100 mg/kg/day + DNBS; (4) 4-APAA 99 mg/kg/day + DNBS; (5) Azo bonded 5-ASA + 4-APAA 199 mg/kg + DNBS. All groups received rectal bid doses of test compounds for the 4 days following induction of colitis. Animals were sacrificed on day 5 and animals were scored for the presence and severity of intestinal lesions (0 to 2 scale). Colon: body weight ratios were also determined. Statistics – t-test was used and P < 0.05 was deemed as significant. RESULTS: Compared to the vehicle/DNBS group, adhesion scores were reduced by 17%, 25%, and 38% in the 5-ASA, 4-APAA and azo bonded 5-ASA + 4-APAA groups respectively. The azo bonded 5-ASA + 4-APAA group was also better than the 5-ASA group. Compared to the vehicle/DNBS group, the average net colon to body weight ratio was reduced by 31.8%, 31.3 % and 31.1 % in the 5-ASA, 4-APAA and azo bonded 5-ASA + 4-APAA groups respectively. No significant difference was observed between the groups. CONCLUSION: The main findings of the present study are that rectally administered 4-APAA alone and azo bonded 5-ASA + 4-APAA are effective inhibitors of experimental colitis in a rat model and that this effect is of similar magnitude to the of 5-ASA. The azo bonded 5-ASA + 4-APAA also trended to better than each component separately, therefore may be a better alternative than single moiety azo preparations.Figure 1.: DNBS Colitis Adhesion Score.

Development of Novel Magneto-Biosensor for Sulfapyridine Detection.

In this work, we report the development of a highly sensitive biosensor for sulfapyridine detection based on an integrated bio micro-electromechanical system (Bio-MEMS) containing four gold working electrodes (WEs), a platinum counter electrode (CE), and a reference electrode (RE). Firstly, the cleaned WEs were modified with 4-aminophenylacetic acid (CMA). Then, (5-[4-(amino)phenylsulfonamide]-5-oxopentanoic acid (SA2BSA) was immobilized onto the transducers surface by carbodiimide chemistry. The analyte was quantified by competitive detection with SA2BSA immobilized on the WE toward a mixture of Ab155 antibody (with fixed concentration) and sulfapyridine. In order to obtain a highly sensitive biosensor, Ab155 was immobilized onto magnetic latex nanoparticles surface to create a 3D architecture (Ab-MLNp). Using electrochemical impedance spectroscopy (EIS), we investigated the influence of the Ab-MLNp on the sensitivity of our approach. The optimized system was analyzed, as competitive assay, with different concentrations of sulfapyridine (40 µM, 4 µM, and 2 nM) and with phosphate buffer solution. From data fitting calculations and graphs, it was observed that the EIS showed more linearity when Ab-MLNp was used. This result indicates that the magnetic latex nanoparticles increased the sensitivity of the biosensor.

Bioprocess Development for the Synthesis of 4-Aminophenylacetic Acid Using Nitrilase Activity of Whole Cells of Alcaligenes faecalis MTCC 12629

Nitrilases are important industrial enzymes to synthesize commercially useful acids from nitriles. In the present study, an aryl specific inducible nitrilase was produced from Alcaligenes faecalis MTCC 12629 which hydrolyzed 4-aminophenylacetonitrile to 4-aminophenylacetic acid. A bioprocess was developed to synthesize 4-aminophenylacetic acid from 4-aminophenylacetonitrile at 500 ml scale under optimized reaction conditions. The maximum activity of nitrilase for biotransformation of 4-aminophenylacetonitrile was recorded in 50 mM KH2PO4/K2HPO4 buffer of pH 7 at 45 °C. Operational stability of present enzyme was found at 45 °C for fed batch reaction. The bioprocess designed at 500 ml scale included 17 U/ml catalyst amount, 50 mM substrate addition after 30 min in total five feedings for 150 min at 45 °C. The approach of substrate feeding at lower amount resulted in accumulation of 175 mM product in 500 ml reaction after five feedings of substrate. The rate of product formation was found to be 2.5 g/gdcw/h with the volumetric productivity of 26.6 g/l.

Development and application of a novel electrochemical immunosensor for tetracycline screening in honey using a fully integrated electrochemical Bio-MEMS

Tetracycline (TC) is a veterinary drug, wildly prescribed for prophylactic and therapeutic purposes. Consequently, its remaining residues in food products have to be regularized. We report in this paper about the development of a novel immunosensor based on an integrated bio micro-electromechanical system (Bio-MEMS) containing eight gold microelectrodes (µWEs), an integrated silver and platinum reference and counter electrodes, respectively. TC immobilization on the µWEs surface was conducted using three methods. The first through functionalization with 4-aminophenylacetic acid (CMA), the second by functionalization with CMA followed by preconcentration of a new structure of magnetic nanoparticles (MNPs) coated with poly (pyrrole-co-pyrrole-2-carboxylic acid) (Py/Py-COOH/MNPs) cross-linked with Ab-TC, and the last one directly through the functionalization with Py/Py-COOH/MNPs. The analyte was quantified by competitive detection with TC immobilized on the µWEs surface toward specific polyclonal antibody (Ab-TC), using a mixture of a fixed concentration of Ab-TC and decreasing levels of TC one from 0.1 pg mL−1 to 1000 pg mL−1. Microcontact printing, followed by fluorescence microscopy characterization were performed during the functionalization of the immunosensor surface to certify that the corresponding immune detection process is taking place. This immunosensor was found to be highly sensitive with a limit of detection of 1.2 pg mL−1 and specific in the presence of interferents. The standard addition method was exploited to detect TC in honey samples. The present immunosensor platform is up-and-coming for TC detection which can dramatically decrease the time of analysis providing a new pathway for advanced immunoassays development in industrial food control.

Impedimetric immunosensor for dengue diagnosis using graphite screen-printed electrodes coated with poly(4-aminophenylacetic acid).

Dengue is an infectious viral disease transmitted by the Aedes aegypti mosquito, the control of which is complex. In addition, the clinical diagnosis is difficult to perform since it resembles other febrile infections; thus, the development of more effective methods to detect dengue virus (DV) has drawn increasing attention. The present study aimed to develop an impedimetric immunosensor for dengue diagnosis using a screen-printed electrode (SPE) functionalized with polymer films derived from 4-aminophenylacetic acid (4-APA). Data obtained from scanning electron microscopy (SEM) showed the deposition of a uniformly distributed material over the electrode surface. The immunosensor was based on the specific interaction between dengue antigen, NS1 protein, and anti-NS1 antibodies, IgG and IgM. In a characterization study using cyclic voltammetry (CV), the polymer film showed two oxidation peaks at +0.17 and + 0.35V in 0.50M sulfuric acid solution, indicating its adsorption and electroactivity at the SPE surface. Electrochemical impedance spectroscopy (EIS) measurements showed a higher charge transfer resistance (Rct) to the polymer film-modified SPE as compared with the bare SPE, corroborating a previous study. The best rNS1 concentration for immobilization was 1.00ng/mL, and the immunoreaction time between the antigen (Ag) and the antibody (Ab) was 20min. Dilutions of positive and negative clinical serum samples were evaluated by EIE, from which it was possible to elucidate, for the positive serum, that the more diluted the serum the greater the Rct. Negative serum also showed an analytical signal, probably due to the presence of non-specific antibodies; however, the generated signal presented values closer to the rNS1 signal, indicating good selectivity of the proposed platform. The experiments were repeated using bare SPE to verify the importance of the polymer film in biosensor construction. No significant difference was observed between these results. Graphical abstract Proposed schematic for the genosensor development.

Electrodeposited Organic Layers Formed from Aryl Diazonium Salts for Inhibition of Copper Corrosion.

Copper substrates deposed on a gold screen-printed electrode were covered with different aryl diazonium salts by electrodeposition at 0.25 mA for 30 or 300 s. Seven compounds were investigated: 4-aminophenylacetic acid, 4-aminophenethyl alcohol, 4-fluoroaniline, 4-(heptadecafluorooctyl)aniline, 4-aminoantipyrine, 4-(4-aminophenyl)butyric acid and 3,4,5-trimethoxyaniline. Quantitative monitoring of the electrodeposition process was carried out by electrogravimetry using quartz crystal microbalance (QCM). The electrodeposited mass varies between 26 ng/cm2 for 4-fluoroaniline formed during 30 s to 442 ng/cm2 for 4-phenylbutyric acid formed during 300 s. The corrosion inhibition properties of aryl-modified layers have been studied in buffer citrate with pH = 3 or 3.5% NaCl solutions using electrochemical noise (ECN) and Tafel potentiodynamic polarization measurements. A corrosion inhibiting efficiency up to 90% was found. The highest corrosion inhibition was obtained for 4-(4-aminophenyl)butyric acid and the lowest for 4-fluoroaniline. A relation between the inhibition efficiency and the chemical nature of the substituents in the protective layer was found.

A pyridyl–carboxylate type linking ligand containing an intervening amide group and its cadmium and nickel coordination polymers: (3-py)–C(O)NH–C6H4–CH2–COOH (HL), {[CdL2](H2O)}∞, and {[NiL2(H2O)2](H2O)}∞

A new pyridyl–carboxylate type linking ligand with an intervening amide group, (3-py)–C(O)NH–C6H4–CH2–COOH (HL), was prepared from 4-aminophenylacetic acid and nicotinoyl chloride hydrochloride. By employing this ligand, two coordination polymers were prepared under hydrothermal conditions: {[CdL2](H2O)}∞ (1) and {[NiL2(H2O)2](H2O)}∞ (2). The ligand exhibits distinct coordination modes in polymers 1 and 2. These bonding modes result in the different topologies: a 2-D layer for polymer 1 and a 1-D double-chain for polymer 2. In the case of polymer 2, several types of hydrogen bonds connect the 1-D polymers to a 2-D network.

Synthesis, characterization, and antimicrobial activity of heterobimetallic complexes of Sn(IV) and Zn(II) with 4-aminophenylacetic acid

A series of new heterobimetallic complexes of zinc and tin with 4-aminophenylacetic acid has been prepared. Their composition and structure in solid state and in solution have been elucidated by elemental analysis, IR, 1H NMR, and 13C NMR spectroscopy. IR spectroscopy results have confirmed the bidentate nature of the ligand, its molecules being arranged in planar square [Zn(II)] and trigonal bipyramid [Sn(IV)] around the metal ions. NMR studies have revealed four-coordinated geometry in the solution. The complexes containing both Sn(IV) and Zn(II) are better antimicrobial agents as compared to the Zn-only analog.