Abstract
Sulfonamides are anti-microbial and anti-inflammatory agents used widely for the treatment of infections. The current research dealt with the synthesis of four sulfonamides formed by the reaction of p-toluenesulfonyl chloride with 4-amino phenyl acetic acid, 5-amino isophthalic acid, 4-piperidine carboxylic acid, and toluidine. The respective structures of sulfonamide drugs were verified by elemental analysis (CHNS), FT-IR spectroscopy, and thermogravimetry. The elemental analysis (CHNS) data conformed to the proposed chemical composition of the products 1-4. The FT-IR spectra verified the formation of sulfonamide drugs. Thermogravimetric analysis (TGA) of data in the range of 25-800oC showed that the evolved components and residues were in good agreement with the molecular skeletons of the products. The antibacterial potential of sulfonamide drugs was evaluated against bacterial strains using the disc diffusion method. The zones of inhibition were found to be larger against Escherichia coli as compared to Bacillus Subtilis. Cytotoxicity of products was in the acceptable range of 0.3-3.1%, as compared to triton X100. It indicates the safety of these products as future medicinal drugs for human beings.
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