Size-specific dose estimates (SSDE) are used to assess patient-specific radiation exposure in Computed Tomography (CT), complementing the volume CT dose index (CTDIvol). This study compared SSDE calculated using patient's lateral size from scan projection radiograph (SPR) with SSDE calculated using water equivalent diameter (Dw) from tomographic images in adult chest high-resolution CT (HRCT). In a single-centre study, the CTDIvol and dose-length product (DLP) were recorded from HRCT dose reports of adult patients. Lateral width (SLat), at the centre of the scan range, from the SPR was measured and the SSDE (SSDER) was calculated using conversion factors related to SLat. Average CT number, area of the slice, and lateral size of the patient (AxLat) were measured on the middle slice. The Dw and SSDE from Dw (SSDEW) were calculated. SSDER and SSDEW were compared using Wilcoxon signed rank test. Correlation between patient size and dosimetry parameters were investigated using Spearman Correlation test with statistical significance at P < 0.05. Bland-Altman plot was also used to test agreement between the two SSDE values. Median CTDIvol, DLP, SSDER and SSDEW were 11.0 mGy, 372 mGy.cm, 11.6 mGy and 12.9 mGy, respectively. Small but statistically significant differences (P < 0.03) were found between SLat and AxLat as well as between SSDER and SSDEW. Bland-Altman analysis resulted in borderline agreement between SSDE values. Moderate correlations were observed between dosimetry quantities and patient size measurements (ρ > 0.640; P < 0.001). SSDEw showed statistically significant correlation (ρ = 0.587 and P < 0.001) with SSDER. SSDER may be used to assess patients' absorbed radiation dose, before the scan, in adult chest HRCT. The median value of SSDER was about 10% lower than the median value SSDEW. However, the SSDEW should be used after the scan to establish effective dose and radiation risk to the patient.