Delayed onset of muscle soreness (DOMS) has debilitating symptoms that produces muscle damage and performance deficits among athletes. Deep oscillation therapy (DOT) is a therapeutic intervention that utilizes an electrostatic wave to create a deep oscillation massage at the cellular level with proposed physiological benefits. There is little evidence to support the use of DOT on exercise-induced DOMS. PURPOSE: Examine the effects of DOT on girth, pain pressure threshold (PPT), perceived pain, strength, and range of motion (ROM) following a bout of eccentric exercise-induced DOMS when compared to control. METHODS: Moderately active participants (age: 22±2.5 years; male: n=5, female: n=5) completed an eccentric exercise protocol for the elbow flexors to induce DOMS as part of a randomized counter-balance design study [Control group (C: no treatment) and a treatment group (T: DOT)]. T group received a 20-minute DOT treatment for 6 days. Visual analog scale assessed pain and a manual algometer assessed PPT and girth was measured at 3 sites on the bicep (5, 9, 13 cm proximal from the antecubital line). A goniometer assessed ROM for extension and flexion. Isokinetic dynameter measured strength for 2 maximum voluntary isometric contractions at 3 angles (30°, 90°, 130°). A 2 x 6 repeated measures ANOVA to examine differences for girth, PPT, perceived pain, ROM, maximum voluntary isometric contraction (MVC) and maximum isokinetic contraction (MIC). RESULTS: A significant main effect was found for perceived pain and PPT between groups (P≤0.01; P=0.002); with significant interactions between days (P≤0.01; P≤0.01). Both displaying improvements for the T group. Girth was significantly different over time for both C and T (2.55 vs. 1.42, P=0.03) and T resulted in a reduction for days 2-6 (P=0.04). Mean ROM significantly changed over time, with Days 2-6 significantly less than Day 1 (P < 0.05), but no significant differences occurred between groups. No differences were found in MVC and MIC at any angles over time or between groups. However, MIC at 30° was decreased over time (5.68 and .41, P=0.001), with Day 2 significantly lower than Day 1 (mean difference 14.5±4.8, P=0.008), with a resulting increase for T when compared to C. CONCLUSION: There are positive effects from DOT on symptoms of exercise-induced DOMS.