Scientific literacy is an essential skill in today's complex information age, particularly in 21st-century education. The inquiry-based learning model, which encourages students to actively engage in research, has been shown to effectively improve scientific literacy. However, combining this model with an ethnoscience approach, which links scientific learning to local cultural knowledge, is important for creating a more comprehensive and relevant learning experience. This study aims to combine the strengths of these two methods to develop a framework for an inquiry-based learning model that incorporates an ethnoscience approach. Through a review of existing literature, the study finds that integrating ethnoscience into inquiry-based learning can enhance student engagement, relevance, and learning impact. The proposed model consists of five key components: Syntax, principles of reaction, social systems, support systems, and instructional effects and follow-up. This approach has shown significant positive effects in adult education, helping students understand science while valuing local cultural knowledge. By fully utilizing the potential of inquiry-based learning, ethnoscience approaches, and scientific literacy, we can create a more inclusive, relevant learning environment that promotes students' overall development.