![Figure][1] In 19th-century Europe and North America, consumption, as tuberculosis was then known, was the most common cause of death. It was so common and disease progression so torpid—patients could often expect to live years, if not decades, with this malady—that the idea that consumption was contagious was unfathomable. A diagnosis of tuberculosis was considered a death sentence, and, although many cures had been proposed, from cod-liver oil to sanatoriums, none of them worked. In The Remedy , science journalist Thomas Goetz describes much more than the fascinating quest to find a cure for tuberculosis. He chronicles the emergence of modern medical science through the pioneering work of Robert Koch and the life of author Arthur Conan Doyle. ![Figure][1] PHOTO: THINKSTOCK The story begins in the 1870s with Robert Koch, then a young provincial doctor in Germany, performing his first experiments to demonstrate that bacteria were the causative agents of anthrax. His meticulous work would lead to the widespread acceptance of the germ theory, the then-radical proposition that diseases are caused by microorganisms (and not by miasma, a pernicious form of “bad air”). The author exposes how breakthroughs do not occur in a vacuum, that discoveries are attributed to those who succeed in convincing others, and how scientists themselves often resist innovation. The book also goes to lengths in describing Koch's rivalry with Louis Pasteur, fueled by French-German antagonism and personal ambition, and how it catalyzed research efforts leading to Koch's discovery of tuberculosis's infective cause, Mycobacterium tuberculosis . This finding was hailed as a revolution as it finally opened the door for a cure. There was even more excitement when Koch announced, a few years later, the discovery of a remedy. This is where Koch and Conan Doyle, also a physician by training, crossed paths. The latter traveled to Berlin and visited patients receiving this mysterious treatment. “Using Koch's own model of logic and analysis,” Conan Doyle attacked this remedy as spoof, noting that Koch's substance had no effect in treating the disease. Goetz posits that Koch “provided the template for Sherlock Holmes's fascination with minuscule detail.” As much as the author would like to convince us, his case remains disputable, as the two men never actually met. Conan Doyle himself said that his inspiration for the famous detective was his former professor, Joseph Bell. That and some digressions on the antivivisectionist and modern antivaccination movements are the book's shortcomings. Despite this, Goetz's pungent account of some of the 19th century's landmark medical discoveries, from antiseptic surgery to the anthrax vaccine, is definitely worth a read. Hopscotching through time and countries, he brilliantly narrates the rise of the two protagonists and how their embrace of deductive logic and scientific methods embodied the spirit of the time. [1]: pending:yes
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