The results of HPV immunotherapy of associated cervical lesions (HSIL) after radio wave conization (534 cases) were analyzed in comparison with the control group (659 cases) in women with a verified process of CIN II-III and CIS, registered at the regional cancer center. In 9.55±1.3% of cases within 2-3 years after the radio wave conization with HSIL (CIN II-III, CIS), the progression of the disease (dysplasia, cancer in situ and in 2 cases cervical cancer of the 1st stage) was established in the control group. The latter was the need for the introduction of 2 cornerstone practices - the control of crypts of the upper cone of the cervix on HPV and immunotherapy. In the study group, HPV was detected in 23.7±1.8% of women after conization in the upper cone. All women in this group were prescribed inosine pranobex (isoprinosine). After the course of treatment, control for HPV and atypia was repeated after 6, 12 and 18 months. Relapses in the group of patients treated with isoprinosine amounted to 0.27 ± 0.5%. The difference is statistically significant - P less than 0.05. At the same time, tracing the path from the moment of screening and detection of HPV-associated HSIL lesions, more than half of women do not receive treatment in a timely manner. For control and continuity between specialists, we have introduced signal cards with the informed consent of a woman for treatment when pathology is detected.