1st Generation Research Articles

Racial, Ethnic, and Immigrant Generational Disparities in Physically Strenuous and Hazardous Work Conditions

Despite the importance of work in adult life, research on the social determinants of health often ignores its effects. We examine race/ethnic, immigrant generational, and gender differentials in exposure to work conditions associated with poor health outcomes, using a nationally-representative sample of adults. On average, Latino 1st generation workers are more exposed to strenuous and hazardous work conditions than other workers, even after adjusting for sociodemographic differences. Exposure is lower for 2nd and 3rd generation Latinos. In contrast, Asian 1st generation men often have the lowest exposure levels of all groups and Asian 2nd and 3rd generation men have higher levels of exposure than the first generation, primarily due to intergenerational differences in education. Asian 1st generation women have higher exposures than those in the 2nd or 3rd generation. These results illustrate the importance of considering work conditions in research and policy related to the social determinants of health.

Molecular Docking, Pharmacokinetic and Molecular Simulation Analysis of Novel Mono-Carbonyl Curcumin Analogs as L858R/T790M/C797S Mutant EGFR Inhibitors.

Curcumin, an anticancer natural compound with multiple pharmacological activities, has a weak pharmacokinetic and instability due to diketone moiety. Curcumin's stability challenges can be overcome by removing the diketone moiety and shortening the 7-carbon chain, resulting in mono-carbonyl analogs. Cancer proliferation is caused by the activation of Epidermal Growth Factor (EGFR) pathways. Current available EGFR inhibitors have an issue of resistance. Thus, we aimed to design new mono-carbonyl curcumin derivatives and analyse their drug likeness properties. Further, to investigate them on three distinct crystal structures, namely two wild-type and L858R/T790M/C797S mutant generations for EGFR inhibitory activity. Ten New Molecular Entities (NME's) were designed using literature survey. These molecules were subjected to comparative molecular docking, on the EGFR crystal structures viz. wild-type (PDB: 1M17 and 4I23) and L858R/T790M/C797S mutant (PDB: 6LUD) using Schrodinger software. The molecules were also tested for Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) properties. The docked complex of the hit molecule was studied for molecular simulation. In molecular docking studies, NMEs 1, 2, and 3 were found to have good binding affinity with 1st , 2nd , and 3rd generation EGFR crystal structures and a greater dock score than standard curcumin. All molecules have shown a good ADMET profile. Since L858R/T790M/C797S is currently being explored more, we decided to take the best molecule, NME 3, for molecular dynamics with 6LUD, and the results were compared with those of the co-crystallized ligand S4 (Osimertinib). It was found that the Relative mean square standard deviation (RMSD) (1.8 Å), Relative mean standard Fluctuation (RMSF) (1.45 Å) and radius of gyration (4.87 Å) values of NME 3 were much lower than those of reference S4. All these confirm that our designed NME 3 is more stable than reference S4. NME 1 and NME 2 have shown better binding against wild type of EGFR. NME 3 have shown comparable binding and more stability as compared to Osimertinib against L858R/T790M/C797S mutated protein structure. The hit compound can be further explored for its Molecular mechanics with generalised Born and surface area solvation (MM-GBSA) and discrete Fourier transform (DFT) studies to find out the energy and atomic level study. In the future, this molecule could be taken for wet lab studies and can be tested for mutated EGFR inhibitory activity.

Forward Light Scattering of First to Third Generation Vitreous Body Replacement Hydrogels after Surgical Application Compared to Conventional Silicone Oils and Vitreous Body.

To treat certain vitreoretinal diseases, the vitreous body, a hydrogel composed of mostly collagen and hyaluronic acid, must be removed. After vitrectomy surgery, the vitreous cavity is filled with an endotamponade. Previously, pre-clinical hydrogel-based vitreous body substitutes either made from uncrosslinked monomers (1st generation), preformed crosslinked polymers (2nd generation), or in situ gelating polymers (3rd generation) have been developed. Forward light scattering is a measure of Stray light induced by optical media, when increased, causing visual disturbance and glare. During pinhole surgery, the hydrogels are injected into the vitreous cavity through a small 23G-cannula. The aim of this study was to assess if and to what extent forward light scattering is induced by vitreous body replacement hydrogels and if Stray light differs between different generations of vitreous body hydrogel replacements due to the different gelation mechanisms and fragmentation during injection. A modified C-Quant setup was used to objectively determine forward light scattering. In this study, we found that the 1st and 3rd generation vitreous body replacements show very low stray light levels even after injection (2.8 +/- 0.4 deg2/sr and 0.2 +/- 0.2 deg2/sr, respectively) as gel fragmentation and generation of interfaces is circumvented. The 2nd generation preformed hydrogels showed a permanent increase in stray light after injection that will most likely lead to symptoms such as glare when used in patients (11.9 +/- 0.9 deg2/sr). Stray light of the 2nd generation hydrogels was 3- and 2-fold increased compared to juvenile and aged vitreous bodies, respectively. In conclusion, this significant downside in the forward light scattering of the 2nd generation hydrogels should be kept in mind when developing vitreous body replacement strategies, as any source of stray light should be minimized in patients with retinal comorbidities.

Load carrying performance of the 2nd and 3rd generation journal bump foil bearings including two dimensional stiffness variations

Journal bump foil bearing (JBFB) is the key component in high-speed turbomachinery. In this paper, load carrying performance of the 2nd and 3rd generation JBFBs with axial and circumferential stiffness variations are investigated applying a curve shell model. A nonlinear algorithm is employed to impose contact/separate and stick/slide constraints to foil structures. An effective inverse method is proposed to design the circumferential variations of bump radii, obtaining evidently wider area (over 110°) where higher film pressure distributes. Reduced stiffness of edge bump strips increases bearing load capacity and frictional energy dissipation particularly for the misaligned rotor. Results indicate the 3rd generation JBFB can achieve over 60% load capacity improvement compared to the 1st generation bearing with uniform bump structure.

Clinical outcomes of ALK+ non-small cell lung cancer in Denmark

Background Real-world clinical outcomes of anaplastic lymphoma kinase positive (ALK+) non-small cell lung cancer (NSCLC) patients vary. This study aimed to investigate the treatment and clinical outcomes of all ALK+ NSCLC patients in Denmark in the period 2011–2018, regardless of disease stage. Materials and Methods A national pathology database with complete coverage was used to identify ALK+ NSCLC patients diagnosed between 2011 and 2018. Clinical data were obtained through retrospective chart reviews. Overall survival (OS) and duration of treatment (DOT) were analyzed using Kaplan-Meier methodologies. Results A total of 209 ALK+ NSCLC patients were included. The cohort had a slight overrepresentation of female patients (56.5%) with a mean age of 61.6 years. Most patients were adenocarcinoma cases (97%) and presented with an ECOG performance status of 0–1 (79%). Stage IIIb–IVb patients comprised 70% of the cohort. The use of ALK-tyrosine kinase inhibitors (TKIs) as first-line treatment increased over time, with the 1st generation ALK-TKI crizotinib being the predominant treatment in the 1st line. In 1st line treatment, 2nd generation ALK-TKIs had a median DOT more than twice the median DOT of crizotinib (25.1 and 9.1 months, respectively). The median OS for the entire cohort was 44.0 months. Patients with stage I–IIIA disease had a median OS that had not been reached, while those with stage IIIb–IVb disease had a median OS of 31.8 months. Patients with stage IIIb–IVb disease receiving an ALK-TKI as 1st line treatment had a median OS of 42.5 months with immature follow-up. Brain metastases at diagnosis or choice of 1st line treatment did not statistically significantly impact OS. Conclusion This study gives insights into the treatment and outcome of ALK+ NSCLC patients in Denmark and provides a real-world confirmation of the superior disease control provided by 2nd generation ALK-TKIs as compared to the 1st generation ALK-TKI crizotinib.

The Impact of Idol Human Brand Characteristics on Idol Worship, Fan Engagement, and Purchase Intention -Focusing on 1st Generation K-POP Idols-

The Impact of Idol Human Brand Characteristics on Idol Worship, Fan Engagement, and Purchase Intention -Focusing on 1st Generation K-POP Idols-

Genetic and non-genetic factors affecting the body weight of the Kurdish local chicken

The current study was conducted at Kani –Graw private field around Erbil city –for the period from 01/09/2022 to 01/05/2023. The study was carried out to know the impact of changes in live weight of Kurdish local chickens due to sex and generation effects. The number of the Kurdish local chicks was two hundred and fifty chicks and their first generation. The effects cleared that, the live weight range substantially in accordance to the sex and generation of the chicks and their interactions especially at some stage in the period from one to eighteen weeks (P<0.01). Also, the live weight in male greater than females and accelerated steadily from zero to eighteen week of age the value the closing weight used to be 1704.06±11.83g and 1380.00±20.50g for males and females parents, respectively and 1649.69±15.64g and 1299.22±10.30g for males and females in 1st generation, respectively. Heritability estimate (h2) indicated that, the heritability estimates for live weight trait. Estimates of h2 two values had been average to excessive the value it ranged from 0.27 to 0.41 for live weight.

PROSPECTS FOR THE PRODUCTION OF ADVANCED BIOFUELS IN UKRAINE

Perspective directions for the development of motor biofuels market in Ukraine are considered. It is shown that Ukraine has a significant potential for the production of liquid biofuels for the transport sector. Today, it is mainly biodiesel and bioethanol of the first generation, since the technologies for obtaining advanced biofuels from lignocellulosic feedstocks are not yet sufficiently developed in the country. However, as these technologies improve, one of directions for the development of motor biofuels market will be the expansion of production opportunities for second generation (advanced) biofuels with a significant share of their export to EU countries. Directive (EU) 2018/2001 on renewable energy sources (RED II) limits the share of 1st generation biofuels in achieving the goals for the consumption of renewable energy in transport. The share of such biofuels in a certain EU country can be no more than 1 % higher than the share of these biofuels in the gross final energy consumption of road and rail transport of that country in 2020, but no more than 7 %. For Ukraine, this means that the share of 1st generation biofuels in the final energy consumption in transport in 2030 cannot exceed 1.85 %, since in 2020 this indicator was 0.85 %. A possible option for solving this problem is to coordinate with the European Commission the issue of increasing the quota of 1st generation biofuels for Ukraine to 7 % in 2030, which is equivalent to the consumption of 503 ktoe/y. In the future, it seems appropriate to develop the production of advanced bioethanol from byproducts of grain corn cultivation as well as advanced biodiesel from oilseed energy crops grown on unused agricultural land. According to RED II, such biodiesel is not subject to restrictions on biofuels produced from food or feed crops. Production and consumption of biomethane is also a promising direction for the introduction of renewable energy in transport. It is shown that the total potential of biogas production in Ukraine is currently 8.16 Mtoe/y, of which a quarter can be allocated for the transport needs. By 2050, the production potential of biogas as a motor fuel may increase to 4.7 Mtoe/y, mainly due to the use of cover crops as feedstock to obtain biogas. Bibl. 21, Tab. 4.

Integrated techno-economic, investment risk and life cycle analysis of Indian lignocellulosic biomass valorisation via co-gasification and syngas fermentation

The current work presents techno-economic and life cycle assessment of a co-gasification- fermentation hybrid model of bio-ethanol production with recycle and recovery of different resources. The model is also equipped with waste heat recovery from the hot syngas and power generation from unconverted syngas. The co-gasification process is based on Gibbs’ free energy minimization and syngas fermentation follows chemical equilibrium. With the objective of studying the economic feasibility and environmental sustainability of the proposed model, techno-economic assessment followed by financial risk analysis and life cycle analysis has been conducted. On the basis of 1 kg product bio-ethanol the results of the life cycle analysis, the present bio-ethanol production process have been compared to those of 1st generation ethanol production and biomass to bio-ethanol conversion via sugar platform. The present process is found to be economically viable with a net present value, internal rate of return and payback period of 18.7 M$, 13.33% and 6.7 years respectively. Monte Carlo simulation of financial risk has been modelled to predict the uncertainty over net present value and 81.8% is the probability of getting a non-negative net present value. Life cycle analysis suggest that the presented process emits 1.23 kg less CO2 per kg of bio-ethanol compared to the conventional bio-ethanol production process from biomass.

Achieving Sustainable Earth Futures in the Anthropocene by Including Local Communities in Critical Zone Science

AbstractCritical Zone Science (CZS) explores the deep evolution of landscapes from the base of the groundwater or the saprolite‐rock interface to the top of vegetation, the zone that supports all terrestrial life. Here we propose a framework for CZS to evolve further as a discipline, building on 1st generation CZOs in natural systems and 2nd generation CZOs in human‐modified systems, to incorporate human behaviour for more holistic understanding in a 3rd generation of CZOs. This concept was tested in the China‐UK CZO programme (2016–2020) that established four CZOs across China on different lithologies. Beyond conventional CZO insights into soil resources, biogeochemical cycling and hydrology across scales, surveys of farmers and local government officials led to insights into human‐environment interactions and key pressures affecting the socio‐economic livelihoods of local farmers. These learnings combined with the CZS data identified knowledge exchange (KE) opportunities to unravel diverse factors within the Land‐Water‐Food Nexus, that could directly improve local livelihoods and environmental conditions, such as reduction in fertilizer use, contributing toward Sustainable Development Goals (SDGs) and environmental policies. Through two‐way local KE, the local cultural context and socio‐economic considerations were more readily apparent alongside the environmental rationale for policy and local action to improve the sustainability of farming practices. Seeking solutions to understand and remediate CZ degradation caused by human‐decision making requires the co‐design of CZS that foregrounds human behavior and the opinions of those living in human modified CZOs. We show how a new transdisciplinary CZO approach for sustainable Earth futures can improve alignment of research with the practical needs of communities in stressed environments and their governments, supporting social‐ecological and planetary health research agendas and improving capacity to achieve SDGs.

The Preliminary Study on the Biology of An Invasive Species, Halyomorpha halys (Hemiptera: Pentatomidae) in Northwest Türkiye

The Brown marmorated stink bug (BMSB) [Halyomorpha halys (Hemiptera: Pentatomidae)] is a polyphagous pest causing significant damage to approximately 300 crops, such as nuts, vegetables, and ornamentals. In 2017, the BMSB was discovered for the first time in Türkiye. There is currently no published data available on the biology of the pest in Türkiye. This preliminary study was carried out in Sakarya province, where the BMSB has observed a low population since 2021. In this study, some biological parameters such as voltinism, mortality rates, egg hatching rates, and egg-adult developmental times of the 1st and 2nd generations of the insect populations were determined. The study was carried out under semi-field conditions and laboratory. Considering the BMSB's minimum temperature threshold, which has yet to be determined in Turkey, the accumulation of degree days was calculated using the references to four possible thresholds (DD12, 12.5, 13, 13.5) and was determined to be between 536.91 - 608.69 DD. The average egg-adult developmental time was 47.85 days for the 1st generation at naturally fluctuating temperatures and 47.13 days for the 2nd generation under laboratory conditions at 25 ֯C. The hatching rate of egg masses was determined to 90.63% in the 1st generation and 57.75% in the 2nd generation. Total mortality in the first generation was 22.97% and 90.24% in the second generation. It was revealed that the insect could produce two generations in Türkiye, but the number of egg-producing adults and eggs laid in the second generation was significantly lower than that in the first. This preliminary study was carried out with a limited number of samples due to the initial infesting in the region and, therefore more comprehensive research is needed to reveal the the biology of BMSB in the country.

(Invited) New Layout Styles to Boost the Electrical, Energy, and Frequency Response Performances of Analog MOSFETs, Considering a Wide Range of High Temperatures

The 1st generation of innovative gate layout styles for MOSFETs have proven to be able to enhance the electrical performance and tolerance to ionizing radiation of analog MOSFETs. This paper presents the 2nd one. It preserves the new effects of the 1st generation and is able to further reduce the Leff of MOSFETs in relation to those achieved by the 1st generation, considering a wide range of high temperatures. We observe that the Half-Diamond layout style is able to boost the saturation drain current and the unity voltage gain frequency by up to 52.4% and 75%, respectively. Therefore, this technique remains an alternative to improve the electrical performance of analog MOSFETs, mainly for space, nuclear and medical CMOS ICs applications. Figure 1

A CONCISE OUTLINE ON INNOVATIVE PERMEATION ENHANCERS IN TRANSDERMAL DRUG DELIVERY APPROACH

The transdermal drug administration system represents a potent substitute for administering medications orally and is also designed to offer a substitute for hypodermic injections. Presently, three generations of penetration enhancer to permeate through skin are available 1st Generation embraces chemical approaches and pertain to augment the efficacy of the drug transferred across the integral skin, 2nd generation encompasses physical permeation technologies and 3rd generation consists of microneedle and needleless penetration enhancers. There is renewed interest in transdermal drug delivery. This review focuses on some existing novel approaches and the additive upshot of techniques for increasing the permeation of drugs via skin penetration. By using the right methods, drug carriers, or certain chemical agents, it is important to cause the stratum corneum to change physically or biomolecularly.

Prospective Randomized Trial of Antibiotic Prophylaxis Duration for Percutaneous Nephrolithotomy in Low-Risk Patients.

Introduction and Objective: Postoperative infection and sepsis account for the most common complications following percutaneous nephrolithotomy (PCNL), as high as 14% in low-risk patients. Although the American Urological Association (AUA) recommends perioperative antibiotics for 24 hours or less for PCNL, practice patterns vary regarding duration of antibiotic therapy. We aimed to compare the efficacy of 24-hour antibiotic coverage vs short-course protocol of antibiotic prophylaxis for PCNL. Materials and Methods: Low-risk patients with a sterile preoperative urine culture undergoing PCNL were prospectively randomized to antibiotics for up to 24 hours after procedure (24Hr) or continued until external urinary catheters were removed (CR) study groups. Patients were given a first generation cephalosporin, or ciprofloxacin in patients with penicillin allergy. Exclusion criteria included age <18 years, receiving antibiotics immediately before the procedure, history of urosepsis, presence of indwelling catheter >1 week, multistage procedure, immunosuppression, pregnancy, multiple antibiotic allergies, and patients who are breastfeeding. Results: Ninety-eight patients were randomized to either 24Hr (n = 49) or CR (n = 49). Mean duration of antibiotic administration was 20.6 and 34.0 hours in the 24Hr and CR groups (p = 0.04), respectively. Age, comorbidities, stone size, operative time, number of punctures, dilations, and proportion of "tubeless" procedures were similar between groups. There were no differences in febrile episodes, rates of systemic inflammatory response syndrome, bacteremia, or culture-proven postoperative urinary tract infection between the 24Hr and CR groups. Overall complication rates were similar between groups. In a subgroup analysis which excluded "tubeless" patients (24 and 29 patients in 24Hr and CR groups, respectively), no differences were seen in postoperative outcomes. Conclusions: In a randomized, prospective study, we found that a 24-hour protocol for antibiotic prophylaxis is not associated with increased risk of infection-related events compared to giving antibiotics until external catheters are removed in patients with low infectious risk undergoing PCNL. Clinicaltrials.gov: NCT02579161.

Time-Frequency Domain Monitoring Method for the Fault of HTS HVDC Systems Based on AI Classifiers

Since high-temperature superconductor (HTS) based HVDC systems are affected by temperature and cooling system performance, noise, the monitoring system which can classify the temporal disturbance and anomalies must be developed to ensure stable system operation. To solve this, it needs anomaly detection that accounts for system sensitivity and is able to continuously manage the response to disturbances. In this paper, we propose an integrated solution for fault severity diagnosis and anomaly detection colorred with AI based reflectometry. Anomalies such as the quench phenomenon can be detected through the anomaly score based on the reconstruction error calculated through the proposed autoencoder(AE) method. After anomaly detection, a fault classification algorithm based on the convolutional neural network (CNN) using a 2D image of a converted reflected signal through the proposed image processing was conducted. Based on the signal acquired from the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$7 m$</tex-math></inline-formula> length 1st generation 22.9 kV/50 MVA HTS cable, PSCAD simulation was utilized to construct a long-distance line model and verified the performance of the proposed algorithm.

IDENTIFICATION OF MICRORGANISMS BY USING AUTOMATED MICROBIAL DETECTION SYSTEM IN ADULT PATIENTSSUSPECTED WITH SEPTICAEMIA WITH ITS SUPPLEMENTARY PARAMETERS

Septicaemia is a major cause of mortality in both developed and developing countries. Despite important progress in treatment and prevention of infectious diseases, they are considered as leading cause of death and disability. The purpose of this study was monitoring the spectrum of microorganisms that invade blood stream and to study role of different markers in septicaemia, such data are often used to determine empiric antibiotic therapy, to alert clinicians to emerging pathogens that may pose a threat to community and also help in diagnosing severity of septicaemia. Aims and Objectives: To isolate and study the microorganisms from septicaemiccases, to study antimicrobial susceptibility of microorganisms isolated from septicemic casesandto study role of different markers in septicemic cases. Which help in diagnosing severity of septicaemia. Methodology: The study was conducted from September 2015 to February 2017 in a tertiary care teaching hospital. 1993 samples were collected from patients clinically suspected patients of septicaemia. They were inoculated and then incubated, and gram staining was performed. Antibiotic resistance and susceptibility were measured by the disk diffusion method according to the Clinical and Laboratory standards institute (CSLI) guidelines Result:Out of 1993 patients having, 695(34.87%) were culture positive. Among Gram negative isolates, Klebsiella spp.(14.96%)was commonest followed by Acinetobacter species (13.66%) ,E.coli (7.76%),Pseudomonas aeruginosa (6.76%) and salmonella spp.(1.29%). Among Gram positive organisms in our study CONS was the commonest (14.53%) followed by S. aureus (10.79%) and Enterococcus (6.18%), Streptococcus species (1.72%). It shows that colistin was found to be more sensitive for gram negative organisms followed by aminoglycosides and carbapenem group, while resistance was observed towards fluoroquinolone, 1st and 2nd generation cephalosporine groups. &amp;Vancomycin, Teicoplanin and Linezolide were highly active drugs against Gram positive organisms. Conclusion:Septicaemia is an important cause of morbidity and mortality. The study conducted showed both Gram positive and Gram-negative bacteria were responsible for septicaemia. Most of the strains were multi drug resistant and leaving limited options for treatment. Thus, timely detection and knowledge of most likely pathogens causing septicaemia along with their antibiotic susceptibility pattern will help the clinicians in choosing appropriate antimicrobials for treatment which will reduce the major burden of septicaemia in critically ill patients and will also minimize the further emergence of resistance. Therefore, there should be an intensive surveillance, antibiotic policy formulations and preventive efforts for the effective management and prevention of drug resistance.

Contact and Gustatory Effects of Spinosad on the Growth or Survivability and Development of Progeny Buildup in Two Successive Generations of Cryptolestes pusillus (Schon.) on Wheat and Rice

The contact and gustatory effects of Spinosad on development, survivability, adult emergence and reproductive potential of Cryptolestes pusillus (Schon.) in two successive generations were conducted. Egg hatching, larval and pupal survivability, and adult emergence were lowest in wheat and rice in 1st generation, whereas, totally controlled the hatching, larval and pupal survivability and adult emergence of C. pusillus was noticed in both the seeds in 2nd generation at 0.63 and 1.25 μg/ml concentrations. The highest PRC value of adult emergence was 97.93% found in wheat and 100% in rice in 2nd generation. The mean developmental period of C. pusillus varied in different concentrations of Spinosad. The highest duration of hatching, larval and pupal periods were observed in treated Spinosad at 1.25μg/ml in wheat in F1 generation, whereas, total control of development was found in F2 generation in the same concentration.

Synthesis of Epichlorohydrin-based Click-dendrons with Different Functional Groups

Abstract: A methodology for synthesizing 1st generation triazole-containing dendrons based on epichlorohydrin with different functional groups was developed using a Cu-catalyzed azide-alkyne cycloaddition reaction (CuAAC) reaction. The proposed methodology uses simple reagents and can serve as a basis for the synthesis of dendrons and dendrimers of higher generations. High reaction yields as well as the cost of starting reagents, make the preparation of such compounds economically and environmentally favorable.

Fabrication of 1st generation aromatic hyperbranched polyester/ polyvinylidene fluoride blended electrospun composites to enrich the piezoelectric performance

Fabrication of 1st generation aromatic hyperbranched polyester/ polyvinylidene fluoride blended electrospun composites to enrich the piezoelectric performance

Effects of plant growth regulators on seed productivity of maize lines

Рurpose and objectives. To study the influence of growth regulators on seed productivity and seeding quality of the development of maternal forms, and the pollen-forming ability of parental forms of corn hybrids, as well as to develop ways of using growth regulators in the primary stages of seed production. Material and methods. The experiments were conducted in the crop rotation fields of the Plant Production Institute named after V.Ya. Yuriev of NAAS in 2018-2019. The experiments were conducted in the crop rotation fields of the Plant Production Institute named after V.Ya. Yuriev of NAAS in 2018-2019. Seeds of maize lines were sown with manual planters in six-row plots of 29.4 m2 (arrangement 4♀:2♂), in four replications. Phenological observations and biometric measurements were performed on 10 plants in each replication. Eight maize lines – hybrids’ parents were taken as the test material: 4 lines – steryl counterparts (Kharkivska 126 M, Kharkivska 215 M, Kharkivska 164 M, and Kharkivska 155 M) and 4 lines – sterility maintainers (Kharkivska 126 ZM, Kharkivska 215 ZM, Kharkivska 164 ZM, and Kharkiv 155 ZM). There were 4 treatments: 1) no treatment (control); 2) Appetizer - spraying in the phase of 4-5 leaves; 3) Nertus Planta Peg – pre-sowing seed treatment; 4) Nertus Planta Peg - pre-sowing seed treatment + spraying in the phase of 4-5 leaves. The stigma viability was determined by sequential removal of plastic bags. To evaluate the accession performance, the following parameters were recorded: - The plant number per plot; - The infertile plant number; - The number of plants with undeveloped cobs; - The number of plants with complete cobs. One average quantitative sample of cobs (10 cobs) was taken and weighed for drying and analyzing the cob structure. Results and discussion. In the lines - steryl counterparts, a significant influence of the growth regulators on the plant weight and condition was observed before the tassel emergence onset. The best response of plants to the PGRs was observed in lines Kharkivska 155 M and Kharkivska 155 ZM. After treatment 2 (Appetizer), we noted the greatest surplus in the biometric parameters in comparison with the corresponding control plots. In the PGR-treated plots, the tassel flowering occurred later and stigmas appeared earlier, which reduced the gap in between the anthesis in the male and female lines. Line Kharkivska 126 showed the best synchrony of anthesis in experiment 2 (Appetizer) - the anthesis time in the male and female forms almost coincided (♂ 27/07 - ♀ 28/07). In the treatment 3 (Nertus treatment of seeds) and 4 (Nertus treatment of seeds + spraying) plots, the anthesis peaks in the both forms coincided (♂ 27/07-♀ 27/07), however, the male forms stopped flowering much earlier than the female ones: there was an anthesis gap (as of 03/08 2% of ♂ forms and 43% of ♀ forms flowered). We recorded a significant increase in the kernel weight of the sample, 1000-kernel weight, the total yield and other indices in the PGR-treated plots in comparison with the corresponding control ones. Nevertheless, in the experiment the 3 treatments (Appetizer, Nertus, Nertus +) influenced the pollen productivity of the maize lines - sterility maintainers. The plant growth regulators had no significant effect the pollen viability in the lines - sterility maintainers. Of the sterile analogues, the PGR effect on the stigma viability was noted for lines Kharkivska 126 M and Kharkivska 215 M. It was less noticeable in the other lines. Conclusions. The results on the growth regulator effectiveness allow us to recommend Appetizer and Nertus Planta Peg as improvers of the seed productivity of the 1st generation maize hybrids’ parents.