5-point Scale Research Articles

Hearing Loss and Discrimination: Evidence of Intersectionality in the All of Us Research Program.

Hearing loss (HL) has significant implications on social functioning. Here, we study the relationship between HL, race, and these combined categories as risk factors for discrimination in the large national All of Us cohort. The National Institutes of Health All of Us dataset was analyzed after including individuals who completed the Everyday Discrimination Survey between November 2021 and January 2022. HL and potential medical confounders were defined per ICD-10 codes or demographics. Multivariable linear regressions analyzing the relationship between HL and discrimination were adjusted for potential confounders, including age, gender, race, ethnicity, other demographic factors, and relevant medical conditions, such as depression and dementia. Additional regressions were conducted to evaluate how combined HL and race categories associated with discrimination risk. Totally 8,722 individuals ≥18 years old had complete data. The mean age was 65 years (SD = 13.0 years), and 41% were women. Individuals with HL, compared with those without, were more likely to report discrimination in six out of nine questions on the Everyday Discrimination Survey (p < 0.05, with effect sizes ranging from -0.05 to -0.16 on a 6-point scale from 0 = "Almost everyday" to 5 = "Never"). Notably, for four out of those six questions, combined Black race and HL was associated with a risk of discrimination independent from the risk conveyed by race and/or HL individually. This study offers evidence of HL as a risk factor for self-reported discrimination. Further, this study provides support for an intersectional understanding between discrimination, race, and HL. III, Laryngoscope, 2024 Laryngoscope, 2025.

The effect of sunflower wax and carnauba wax on the storage stability and sensory evaluation of palm-based chocolate spread

This study investigates the storage properties and sensory evaluation of palm-based chocolate spreads formulated with sunflower wax (SFW) and carnauba wax (CW) in a wide range of temperatures. Hardness, spreadability and stability assessments of chocolate spreads with 3.5% SFW and 3.5% CW were made over a 24-week storage period. The hardness, spreadability and stability of the chocolate spreads were analyzed by means of Texture Analyzer, observation and LUMiFuge Stability Analyzer, respectively. A sensory evaluation of these chocolate spreads was conducted using a 7-point hedonic scale. The hardness of both chocolate spreads was influenced by low temperatures of 5-10 °C during the storage study. Decreasing and increasing trends were observed for samples stored at 5 and 10 °C, respectively. However, both palm-based chocolate spreads remained spreadable at 5 °C even after 24 weeks of storage. Both chocolate spreads demonstrated stability at 40 °C after 24 weeks of storage. The sensory evaluation revealed that chocolate spread with 3.5% CW was the most widely accepted by sensory panelists. Therefore, chocolate spread with 3.5% CW has the potential to be utilized over a wide range of temperature applications of 5-40 °C.

Development and validation of the pain management competency scale for nurses and a nationwide survey of Chinese nurses

BackgroundNurses’ competency in pain management is essential for effectively alleviating patients' acute pain, controlling chronic pain, and promoting patient recovery. However, reliable tools for evaluating these competencies across different clinical specialties and healthcare settings are lacking. This study aimed to develop and validate a Pain Management Competency Scale for Nurses (PMCSN) and to assess the pain management competencies of nurses in China through a nationwide survey.MethodsAn item pool and a draft scale were developed through literature reviews, semi-structured interviews, and expert panel discussions. This was followed by refinement of the scale via Delphi expert consultations and a pilot test. To validate the scale, 342 nurses were conveniently sampled from six hospitals in Eastern and Central China. The validation process included item analysis, internal consistency reliability assessment, test–retest reliability (with 40 nurses retaking the questionnaire after a 14-day interval), content validity (evaluated by six experts using a 4-point Likert scale), and structural validity (assessed through exploratory and confirmatory factor analyses). The validated scale was then applied in a survey of 1,500 nurses from 15 hospitals across Eastern, Central, and Western China. Statistical analyses included descriptive statistics, analysis of variance (ANOVA), and t-tests.ResultsThe PMCSN comprised six primary dimensions—Pain Assessment and Monitoring, Pharmacological Pain Management, Non-Pharmacological Pain Management, Management of Analgesic Adverse Effects, Patient/Family Education, and Professional Development—and includes 52 tertiary items. The PMCSN scores ranged from 6 to 120, calculated by summing the standardized scores across the six dimensions, with higher scores indicating greater competency in pain management. The scale’s Cronbach’s α was 0.974 (dimension-specific values ranging from 0.863 to 0.935) and a test–retest reliability of 0.871. The content validity index (CVI) of the scale was 0.965. Exploratory factor analysis (EFA) showed that the six-factor model explained 67.50% of the variance. Confirmatory factor analysis (CFA) indicated good model fit, with average variance extracted (AVE) values ranging from 0.659 to 0.811 and composite reliability (CR) between 0.909 and 0.973, confirming good convergent validity. The square roots of the AVE values exceeded the inter-factor correlations, indicating good discriminant validity. In the nationwide survey, the average PMCSN score among 1,500 nurses was 101.27 ± 20.97. Nurses with higher education levels scored higher (F = 14.173, p < 0.01), as did those working in Eastern regions (F = 24.632, p < 0.01) and tertiary hospitals (T = -5.476, p < 0.01).ConclusionsThe PMCSN is a valid and reliable tool for assessing nurses’ pain management competencies. It provides a standardized approach for evaluation and guides targeted interventions to improve competency. Regional and hospital-level disparities highlight the need for enhanced training in underdeveloped areas and collaboration between hospitals to promote balanced healthcare resources.

Effect of adaptive statistical iterative reconstruction-V algorithm and deep learning image reconstruction algorithm on image quality and emphysema quantification in COPD patients under ultra-low-dose conditions.

To explore the effect of different reconstruction algorithms (ASIR-V and DLIR) on image quality and emphysema quantification in chronic obstructive pulmonary disease (COPD) patients under ultra-low-dose scanning conditions. This prospective study with patient consent included 62 COPD patients. Patients were examined by pulmonary function test (PFT), standard-dose CT (SDCT) and ultra-low-dose CT (ULDCT). SDCT images were reconstructed with filtered-back-projection (FBP), while ULDCT images were reconstructed using FBP, 30%ASIR-V, 60%ASIR-V, 90%ASIR-V, low-strength (DLIR-L), medium-strength (DLIR-M) and high-strength DLIR (DLIR-H) to form 8 image sets. Images were analyzed using a commercial computer aided diagnosis (CAD) software. Parameters such as image noise, lung volume (LV), emphysema index (EI), mean lung density (MLD), 15th percentile of lung density (PD15) were measured. Two radiologists evaluated tracheal and pulmonary artery image quality using a 5-point scale. Measurements were compared and the correlation between EI and PFT indices was analyzed. ULDCT used 0.46 ± 0.22mSv in radiation dose, 93.8% lower than SDCT (P < 0.001). There was no difference in LV and MLD among image groups (P > 0.05). ULDCT-ASIR-V90% and ULDCT-DLIR-M had similar image noise and EI and PD15 values to SDCT-FBP, and ULDCT-DLIR-M and ULDCT-DLIR-H had similar subjective scores to SDCT-FBP (all P > 0.05). ULDCT-DLIR-M provided the best correlation between EI and the FEV1/FVC and FEV1% indices in PFT, and the lowest deviations with SDCT-FBP in both EI and PD15. DLIR-M provides the best image quality and emphysema quantification for COPD patients in ULDCT. Ultra-low-dose CT scanning combined with DLIR-M reconstruction is comparable to standard dose images for quantitative analysis of emphysema and image quality.

Importance and fitness of family medicine milestone project from America to Taiwan

BackgroundThe six core competencies of ACGME - patient care (PC), medical knowledge (MK), systems-based practice (SBP), practice-based learning and improvement (PBLI), professionalism (PROF), and interpersonal and communication skills (ICS) - represent domains in which physicians must ultimately demonstrate competence. Although the ACGME’s six core competencies have been applied in Taiwan with the milestone project, the application of the six core competences in the Family Medicine milestones for residency training have not yet been established.MethodsWe recruited 61 family medicine physicians from 25 hospitals from four major geographic areas for a Delphi round one survey and 72 physicians from 27 hospitals for a Delphi round two survey. With 5-point scales, the Cronbach’s alphas for both importance and fitness were 0.98 in round one. In round two, the Cronbach’s alphas were 0.86 and 0.83 for importance and fitness. The mode and quartile deviation in Delphi method, importance-performance analysis (IPA), and importance-performance matrix analysis (IPMA) were used for three stages IPA process.ResultsIn IPA, a total of 72.7% (16/22) of the sub-competencies exhibited high importance and fitness, with a mean score ≥ 4.7; the exceptions were PC-1 (cares for acutely ill or injured patients), MK-2 (critical thinking skills in patient care), SBP-1 (cost-conscious medical care), PBLI-3 (improves systems), PROF-3 (humanism/cultural proficiency), and ICS-4 (utilizes technology). In IPMA, the performance value of six core competencies for FMM-Taiwan was 92.6 when considering the importance and fitness indices of the 22 sub-competencies.ConclusionsThe accordance of the ACGME’s milestones to Taiwan was acceptable to good and related milestones could been developed for residency training.

Non-Ablative Fractional 1940-nm Diode Laser for Skin Resurfacing and Treatment of Benign Pigmented Lesions.

The non-ablative 1940-nm laser induces controlled thermal damage at superficial depths without ablating the epidermis. We evaluated a new 1940-nm fractional diode laser for improving pigmentation and skin texture. Participants with mild to severe benign pigmented lesions received up to three laser treatments. Blinded evaluation of randomized pretreatment versus 1-month posttreatment photos was conducted by three independent dermatologists to identify the correct posttreatment image and assess pigmentation on a 5-point scale (0 = 0% improvement, 4 = 75%-100% improvement) and skin texture improvement. Fifty-four subjects (50 females; Fitzpatrick skin types I-IV) with pigmented lesions on the face or body underwent a total of 172 treatments. Blinded evaluation of 45 photography sets resulted in a 91% success rate of correct identification of posttreatment photos with a mean pigmentation improvement score of 2.0 (p < 0.05) and improvement in skin texture for 62% of treated areas. Mild to moderate edema (70%) and erythema (88%) were observed immediately posttreatment. Trace melasma recurrence in three subjects and one case of mild rash resolved during the study. Non-ablative fractional 1940-nm diode laser skin resurfacing is safe and effective at improving overall skin quality and treating pigmentation after 2-3 treatments. Long-term follow-up of clinical outcome is warranted.

A convolutional neural network model and algorithm driven prototype for sustainable tilling and fertilizer optimization

Tilling, a common agricultural practice, is being done excessively on farms leading to about 2.35 billion tons of soil erosion from US croplands annually, in addition to causing soil infertility, carbon release, nutrient runoff, and fertilizer over-usage. This paper evaluates whether optimizing tillage intensity, timing, and fertilizer quantity using a convolutional neural network model and algorithm will address these problems. The machine learning model utilizes a camera-captured field image to determine existing tilling intensity on a 7-point scale. This machine learning output, along with soil sensor and external forecast data, flows into a 10-parameter algorithm that determines optimal tilling and fertilizer levels. A fully functional tractor prototype demonstrates the above. A 30-year simulation comparing conventionally-tilled and algorithm-tilled farms showed a reduction in carbon emission by 57%, fertilizer usage by 43%, and runoff by 86% demonstrating the transformative potential of this algorithm. Additionally, a stationary prototype was deployed in 155 farms across 5 countries.

Quantitative and Visual Benefits of Data-Driven Motion Correction on Oncologic PET/CT: AProspective Cross-sectional Study.

Conventional positron emission tomography (PET) respiratory gating utilizes a fraction of acquired PET counts (i.e., optimal gate [OG]), whereas elastic motion correction with deblurring (EMCD) utilizes all PET counts to reconstruct motion-corrected images without increasing image noise. Our aim was to assess the quantitative and visual impacts of EMCD-based motion correction on FDG-PET and DOTATATE-PET images relative to OG and ungated (UG) images. This prospective, single-center study enrolled adults undergoing FDG or DOTATATE oncologic PET/CT between June 2020 and October 2022. Subjects underwent a standard-of-care (SOC) PET acquisition while wearing a respiratory gating belt. UG, belt-gating-derived optimal gate (BG-OG), EMCD utilizing belt gating (BG-EMCD), and EMCD utilizing data-driven gating (DDG-EMCD) images were reconstructed. Tracer-avid lesions in the lower chest or upper abdomen were segmented. Quantitative metrics were extracted. Two independent, blinded readers assessed image quality via a 4-point scale and counted lesions on each reconstruction. Differences between reconstructions were assessed via the Wilcoxon signed-rank test (alpha, 0.05). This study enrolled 78 subjects; 36 subjects (mean age, 64.8 years; 20 males) with 136 tracer-avid lesions were analyzed. Data provided are medians across all tracers. Lesion SUV-max was significantly higher (P<0.001) on motion-corrected images (BG-OG: 10.77, BG-EMCD: 10.75, DDG-EMCD: 10.74) than UG images (9.00). Lesion contrast-to-noise ratios (CNRs) were significantly lower (P<0.001) for BG-OG (6.31) and UG images (7.89) than BG-EMCD (9.14) and DDG-EMCD (8.89) images. FDG and DOTATATE subgroup analyses produced similar results. Among motion-corrected images, both readers preferred EMCD-based images to BG-OG images for all tracers (P<0.001) and both subgroups. EMCD-based images occasionally demonstrated more tracer-avid lesions than BG-OG or UG images. EMCD-based motion correction beneficially impacts lesion quantitation (including higher SUVs and CNRs) and overall image quality. When employed on capable scanners, EMCD can improve the quality of oncologic PET imaging.

The burnout dimension emotional exhaustion and impairment of work participation: A prospective study of 2308 employees subject to social security contributions in Germany

The present study examines the relationship between the burnout dimension emotional exhaustion and subsequent events of work nonparticipation (long-term sickness absence, unemployment, early retirement) and their duration.The data basis was the Study on Mental Health at Work (S-MGA); a follow-up study based on a random sample of n=4511 employees subject to social security contributions aged 31-60 years at baseline and their follow-up after 5 years (n=2460). Burnout symptoms were measured at the time of the baseline survey by means of a questionnaire, while the employment and sickness absence history was recorded at follow-up by means of an interview. Associations between the burnout scale at T1 and subsequent events of inactivity were analysed using a two-part model: i. e., events were predicted using logistic regression, and their duration was predicted using generalised linear regression models (GLM).The burnout scale was associated with the events and duration of long-term sickness absence; among men with an odds ratio [OR]=1.72 (95% CI=1.31; 2.27) and among women with an OR=2.23 (95% CI=1.73; 2.88) per scale point for the occurrence of an event. Among those who experienced long-term sickness absence, the duration (in months) increased by a factor of Exp(β)=1.44 (95% CI=1.23; 1.69) for men and Exp(β)=1.29 (95% CI=1.09; 1.52) for women for each scale point on the burnout scale.From a clinical and health economic point of view, it is a relevant finding that the burnout dimension of emotional exhaustion is associated with events and duration of work nonparticipation.

Psychometric analyses of the eating and food literacy behaviors questionnaire with cooking enjoyment

ABSTRACT Food literacy is defined as possessing the knowledge, skills, and behaviors to consume a healthy diet. The Eating and Food Literacy Behaviors Questionnaire (EFLBQ) was developed and validated to measure food literacy in young adults. The current study examined if adding additional items to the EFLBQ would improve the questionnaire. Students, aged 18–30 years, were recruited from US universities. Questions were answered using a 4-point Likert scale with choices of never = 1, seldom = 2, often = 3, and always = 4. Additional items were added to the EFLBQ, and exploratory factor analysis (EFA) revealed that three statements clustered into a new factor titled cooking enjoyment. Four additional cooking enjoyment statements were added, and the seven statements were tested with EFA (n = 424). EFA of the cooking enjoyment statements returned six statements. The cooking enjoyment statements were added to the EFLBQ, and the instrument was titled the EFLBQ-C. Responses to the EFLBQ-C (Group 1: N = 258) were compared to those of the EFLBQ (Group 2: n = 257) using confirmatory factor analysis (CFA) and point estimate reliability testing. The EFLBQ-C CFA retained all 19 EFLBQ statements in the five original constructs and retained the cooking enjoyment factor as a sixth construct. The EFLBQ CFA retained the 19 original statements and five constructs. The chi-square was significant for both groups (p < .001). The RMSEA cutoff was for Group 1 = 0.054 and Group 2 = 0.052. Both groups reported CFI = 0.94, TLI = 0.93, and SRMR = 0.05. The Eating and Food Literacy Behaviors Questionnaire with Cooking Enjoyment (EFLBQ-C) is valid and explains an additional food literacy factor than the EFLBQ.

Exploring Teaching Methodologies and Business Management Education's Impact on Entrepreneurial Success

This study examines the impact of teaching methodologies in Business Management Education on the entrepreneurial success of 2023 alumni from Nueva Ecija University of Science and Technology. Using a descriptive research design and a 4-point Likert scale questionnaire, it analyzes alumni perceptions of instructional approaches and their influence on entrepreneurial skills, curriculum content, and support services. The findings emphasize the importance of experiential learning and practical skill application, suggesting enhancements in resilience training, resource access, and post-graduation support. This research provides actionable insights for educators and policymakers to optimize business management education for entrepreneurial success.

Predictors of online and offline activism in hybrid regime society - Serbian study.

In Serbia, categorized as a hybrid or semi-authoritarian system by Freedom House, exploring activism is crucial. Two cross-sectional studies were conducted to examine predictors of online and offline civic activism in a society favouring punitive measures and limiting open dialogue. The first study involved 1107 participants (65.1% female, 33.2% male and 1.6% in other categories; Mage = 28.15 years), while the second included 2306 individuals (67.5% female, 30.2% male and 2.3% in other categories; Mage = 28.1 years). We modelled the relationship between predictor variables and a dependent variable at different quantiles of the distribution (25th, 50th, 75th and quantile marked with theoretical middle points of online and activism scales) using quantile regression. Results highlighted perceived policy control, social generativity and conscientiousness as key predictors across different levels of both online and offline activism. Personality traits like extroversion, neuroticism and honesty have different effects on online versus offline activism, suggesting different motivations. Additionally, future-oriented people participate more offline. The quantile regression, analysing coefficients at different points in the distribution, offered valuable insights into manifestations of activism. These findings are discussed highlighting the complex dynamic of different factors in shaping civic engagement in Serbia's challenging sociopolitical landscape.

Translation of PET radiotracers for cancer imaging: recommendations from the National Cancer Imaging Translational Accelerator (NCITA) consensus meeting

BackgroundThe clinical translation of positron emission tomography (PET) radiotracers for cancer management presents complex challenges. We have developed consensus-based recommendations for preclinical and clinical assessment of novel and established radiotracers, applied to image different cancer types, to improve the standardisation of translational methodologies and accelerate clinical implementation.MethodsA consensus process was developed using the RAND/UCLA Appropriateness Method (RAM) to gather insights from a multidisciplinary panel of 38 key stakeholders on the appropriateness of preclinical and clinical methodologies and stakeholder engagement for PET radiotracer translation. Panellists independently completed a consensus survey of 57 questions, rating each on a 9-point Likert scale. Subsequently, panellists attended a consensus meeting to discuss survey outcomes and readjust scores independently if desired. Survey items with median scores ≥ 7 were considered ‘required/appropriate’, ≤ 3 ‘not required/inappropriate’, and 4–6 indicated ‘uncertainty remained’. Consensus was determined as ~ 70% participant agreement on whether the item was ‘required/appropriate’ or ‘not required/not appropriate’.ResultsConsensus was achieved for 38 of 57 (67%) survey questions related to preclinical and clinical methodologies, and stakeholder engagement. For evaluating established radiotracers in new cancer types, in vitro and preclinical studies were considered unnecessary, clinical pharmacokinetic studies were considered appropriate, and clinical dosimetry and biodistribution studies were considered unnecessary, if sufficient previous data existed. There was ‘agreement without consensus’ that clinical repeatability and reproducibility studies are required while ‘uncertainty remained’ regarding the need for comparison studies. For novel radiotracers, in vitro and preclinical studies, such as dosimetry and/or biodistribution studies and tumour histological assessment were considered appropriate, as well as comprehensive clinical validation. Conversely, preclinical reproducibility studies were considered unnecessary and ‘uncertainties remained’ regarding preclinical pharmacokinetic and repeatability evaluation. Other consensus areas included standardisation of clinical study protocols, streamlined regulatory frameworks and patient and public involvement. While a centralised UK clinical imaging research infrastructure and open access federated data repository were considered necessary, there was ‘agreement without consensus’ regarding the requirement for a centralised UK preclinical imaging infrastructure.ConclusionsWe provide consensus-based recommendations, emphasising streamlined methodologies and regulatory frameworks, together with active stakeholder engagement, for improving PET radiotracer standardisation, reproducibility and clinical implementation in oncology.

Procedural Entrustment Alignment Between Pediatric Residents and Their Preceptors in the Pediatric Emergency Department.

Entrustment describes the balance of supervision and autonomy between resident and preceptor to complete doctoring tasks like procedures. Entrustment alignment between resident and preceptor facilitates safe, successful outcomes, and promotes learning. Study objectives describe procedural entrustment alignment between senior pediatric residents and their preceptors and report the impact of a simulation-based formative assessment (SFA) on entrustment alignment. This prospective observational study enrolled a convenience sample of senior pediatric residents in 2023. The SFA was videoed, consisted of obtaining informed consent and performing simulated procedures (laceration [LAC] and lumbar puncture [LP]). Residents self-assessed their entrustability pre/post-SFA. A PEM preceptor panel individually rated videos of the residents. PEM panel's scores were compared to residents' scores on both an 8-point scale and the dichotomized variable of needing "in versus out" of the room entrustment. Twenty-four residents' SFAs were rated by 9 panelists. Before the SFA, entrustment alignments on the 8-point scale were as follows: resident LAC 4.08 vs PEM panel 4.97 (P < 0.001), and resident LP 4.75 vs PEM panel 5.31 (P = 0.15). After the SFA, entrustment alignments were as follows: resident LAC 5.21 vs PEM panel 4.97 (P = 0.32), and resident LP 5.54 vs PEM panel 5.31 (P = 0.52). The dichotomized analyses revealed improved alignment post-SFA: LAC-pre-kappa = 0.03 vs LAC-post 0.46, and LP-pre-kappa = (-0.03) vs LP-post = 0.24. Our findings indicate senior pediatric residents desire less entrustment (more supervision) for procedures but better align with preceptors after an SFA. This work offers insight into procedural entrustment decision making and the potential of SFA's to facilitate procedural learning.

ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ ВТОРИЧНОГО СЫРЬЕВОГО РЕСУРСА (ЖМЫХА ЛЬНА) В ПРОИЗВОДСТВЕ ОВСЯНОГО ПЕЧЕНЬЯ

The purpose of the study is to develop a new recipe for oatmeal cookies with a partial replacement of traditional ingredients with linseed cake. Tasks: to develop a recipe for oatmeal cookies with a partial replacement of margarine with linseed cake; to carry out a tasting assessment of the manufactured oatmeal cookies, to determine the physicochemical and organoleptic characteristics of the obtained products at various dosages of the included component. The object of the study is control samples of oat products with the addition of flax cake. Laboratory baking was carried out according to the classic recipe for oatmeal cookies with partial replacement (20; 30; 40 and 50 %) of margarine for linseed cake. Physical and chemical parameters of baked oatmeal cookies were carried out according to GOST 5898-87; GOST 5900-2014, GOST 5903-89, GOST 10114-80, GOST 31902-2012. The evaluation of the organoleptic characteristics of the produced samples of oatmeal cookies with partial replacement of the classic ingredient with linseed cake was carried out on a 5-point scale. The organoleptic studies carried out showed the compliance of the produced flour confectionery product (oatmeal cookies with 30 % replacement of margarine with flaxseed cake) to the regulatory documentation, the samples obtained had the traditional taste and smell of oatmeal cookies with a pleasant nutty aftertaste, an oval shape with a slight vagueness and a uniform porous structure at the break. The results of the physicochemical parameters of oatmeal cookies baked with 30 % replacement of margarine with linseed cake (mass fraction of moisture – 9.1 %, mass fraction of total sugar (according to sucrose) – 32.9 %, mass fraction of fat – 19.7 %, wetness – 170.0 %, alkalinity 1.8 degrees) comply with the requirements of regulatory documentation – GOST 24901-2014. The results obtained make it possible to recommend the developed new type of oatmeal cookies to expand the range of "healthy" flour confectionery products.

P0489 The impact of inflammatory bowel disease and disease activity on patients’ sexuality

Abstract Background Sexuality is an integral part of general health and wellbeing. Chronic diseases, such as inflammatory bowel disease (IBD), have an impact on patients’ sexual functioning. The aim of this study was to assess the influence of intestinal disease and its activity on sexuality of individuals with IBD. Methods: Patients and Methods A prospective survey study on male and female individuals with IBD using an anonymous questionnaire including 60 inquiries concerning patients ‘intimate relationship and sexual functioning was performed. The following statistical tests were used: chi-square test of independence, Spearman’s rank correlation coefficient, Wilcoxon and U Mann-Whitneyatests. The significance level of p = 0.05 was assumed as statistically significant. Results The survey involved 110 respondents with IBD (41% with Crohn’s disease and 57% with ulcerative colitis) - 52 women (47%) and 58 men (53%). Most of them were aged between 31 and 40 (45%). Before being diagnosed with IBD, the respondents rated their satisfaction with sex on an average of 4.1 on a 5-point scale; after the diagnosis, the rating was lower and amounted to 3.6. In 34% of respondents, the assessment of satisfaction with sex after diagnosis decreased, in 24% it increased, and in 42% it did not change. The difference between the assessments before and after diagnosis was statistically significant (p = 0.007). Statistically significant correlations were found between IBD clinical activity and the impact of the disease on the sexual desire (p &amp;lt; 0.001), the need for sex after diagnosis (p &amp;lt; 0.001), satisfaction with sex after diagnosis (p = 0.003), and the average number of intercourse (p = 0.004), average duration of intercourse after diagnosis (p = 0.001), feeling guilty in the sexual sphere due to the disease (p = 0.006), assessment of one’s attractiveness since diagnosis (p = 0.032), and change in the partner’s erotic perception after diagnosis ( p &amp;lt; 0.001). Respondents with disease exacerbation were less willing to engage in sexual activity, had less need for intercourse, rated their satisfaction with sex lower, had fewer intercourse, and their duration was shorter. They more often felt sexual guilt due to the disease and assessed their current attractiveness worse. Conclusion Inflammatory bowel disease has negative impact on patents’ sexuality and disease activity strongly affects their sexual functioning. The exacerbation of IBD causes in patients decrease in sexual needs, worse sexual experience and lower assessment of one’s attractiveness.

P0479 The impact of inflammatory bowel disease on sexuality of male and female patients

Abstract Background Inflammatory bowel disease (IBD) is a chronic condition that globally affects the health of individuals who suffer from it, deteriorating their quality of life (QoL), which includes one’s sexual functioning. The aim of this study was to assess the influence of intestinal disease on sexuality of male and female with IBD. Methods: Patients and Methods A prospective survey study on male and female individuals with IBD using an anonymous questionnaire including 60 inquiries concerning patients ‘intimate relationship and sexual functioning was performed. The following statistical tests were used: chi-square test of independence, Spearman’s rank correlation coefficient, Wilcoxon and U Mann-Whitneyatests. The significance level of p = 0.05 was assumed as statistically significant. Results The survey included 110 respondents with IBD (41% with Crohn’s disease and 57% with ulcerative colitis) - 52 women (47%) and 58 men (53%). Most of them were aged between 31 and 40 (45%). Statistically significant differences were found in the assessment of satisfaction with sex after IBD diagnosis between the groups - female vs male (p = 0.041). Women gave different ratings on a 5-point scale, most often 1 (23%), 4 (23%) and 5 (27%), while men most often gave 4 (49%) and 5 (26%). Despite the disease, men were more likely than women not to give up sexual activity: 53% vs 43%, respectively (p = 0.011). While women were more likely than men to be afraid that after being diagnosed with IBD they would be less attractive to their partner: 31% vs 10%, respectively (p = 0.002). Nearly 31% of women after diagnosis of IBD did not have orgasm or achieved it less frequently than before the diagnosis, which was less common in men (4%). The difference was statistically significant (p = 0.002). Men more often than women did not change their erotic perception of the partner after IBD diagnosis: 71% vs 39%. The difference was statistically significant (p = 0.001). Women (70%) were more likely than man (28%) to expect a gastroenterologist to inform about sexuality and fertility in IBD. The difference was statistically significant (p &amp;lt; 0.001). Conclusion According to our survey IBD has more negative impact on sexuality of female patients. After the diagnosis women were less satisfied with sex, felt less attractive to their partner and more often resigned from sexual intercourse because of the disease. However, women were more interested in information about sexuality and fertility in IBD than men.

P0778 Exploring the impact of personalised and curated educational videos delivered via an online platform to paediatric IBD patients

Abstract Background Paediatric IBD patients and families want reliable, easily accessible information from sources they trust. Appointment time is limited and teams spend much of that time repeating basic information. Families often struggle to remember/process information imparted in appointments, and have no way to check details/ask further questions, resulting in misunderstanding, anxiety and information being sought from unregulated sources. Patients and families feel isolated and unsupported between appointments. In this study we looked at 12 months use of IBDmate, an online platform for patient education and present initial results of a high-level survey. Methods IBDmate is an online education platform (figure 1) featuring over 150 videos filmed with healthcare professionals and patients. It offers ‘prescribable information about all aspects of IBD, including patient and family members’ stories. During a 12 month period, 104 paediatric IBD patients under the care of Addenbrooke’s Hospital in Cambridge were signed up to IBDmate. They were prescribed educational video modules at diagnosis and at appropriate times during following appointments. Over the 12 months, a total of 1,116 videos were watched by these patients (average &amp;gt;10 per patient) for a total of 64 hours (average &amp;gt;36mins per patient). At the end of this period we conducted a survey to gather feedback from patients and families using IBDmate. We asked the following questions assessed on a 5-point scale (table 1). Results 43 patients of 104 asked (41%) and family members responded to the survey over a period of 72 hrs. • 83.72% (n=36) of respondents strongly agreed or agreed that IBDmate helped them understand their/their child’s disease better. • 86.05% (n=37) of respondents strongly agreed or agreed that IBDmate helped them understand treatments available to them/their child and make better informed decisions about their care. • 88.37% (n=38) of respondents strongly agreed or agreed that having access to patient/family stories in IBDmate helped them feel less alone. • 88.37% (n=38) of respondents strongly agreed or agreed that having access to IBDmate had been beneficial to them/their family. Conclusion Paediatric patients and families who use IBDmate are better informed and better equipped to manage their disease. They feel more confident making decisions about their care, and feelings of isolation are significantly reduced. Anecdotally IBDmate reduced the need for in-person consultations, especially for routine education about treatments and disease management. This represents a key next step for the impact assessment of IBDmate.

P0840 Health related quality of life (HRQOL) in patients with ulcerative colitis (UC) treated with obefazimod: the phase 2 open label maintenance study

Abstract Background Obefazimod is an investigational, oral, once-daily (QD), small molecule which enhances expression of microRNA-124 and demonstrated efficacy in patients (pts) with moderately to severely active UC at Week 8 of a phase 2b induction trial. The proportion of pts achieving clinical endpoints increased at Week 48 in the subsequent open-label maintenance study (OLM). Here we report long term effects of obefazimod on HRQOL. Methods In the phase 2b trial, pts were randomized 1:1:1:1 to receive 100 mg, 50 mg, or 25 mg oral, obefazimod or placebo (PBO) QD for 16 weeks. The primary endpoint was at Week 8. If pts completed the 16-week induction trial, regardless of clinical/symptomatic response or randomized dose received, they could be enrolled in the OLM and receive 50 mg QD through Week 48. Pts completed the IBDQ, a disease-specific HRQOL questionnaire consisting of 32 items across 4 domains (Emotional functioning, Bowel symptoms, Social functioning, Systemic symptoms) at baseline and Week 8 of the induction trial and Week 48 of the OLM. The IBDQ items are assessed on a 7-point scale with scores ranging from 32 to 244; higher scores reflect better well-being. Mean value by visit and mean change in IBDQ from Week 8 to 48 were reported descriptively. The proportion of pts with IBDQ remission (IBDQ total score ³170) at Weeks 8 and 48 and IBDQ response ( ³16 point increase in IBDQ total score) from Week 8 to 48 were determined. Pts that received at least 1 dose and had baseline IBDQ data were included in this analysis. Data were analyzed as observed. Results 222 pts completed the induction trial, 217 continued in the OLM. 178 pts were included in this analysis. Across IBDQ total score and domains, further improvements in HRQOL were obtained after Week 8 with continued obefazimod treatment to Week 48. The largest increases were observed in pts who received PBO in the induction trial and then 50 mg in the OLM. Mean change from Week 8 to 48 in IBDQ total score was (mean (SD)) = 25.6 (28.8), 29.7 (34.9), 17.0 (26.5), and 38.7 (30.3) for pts in the 100 mg, 50 mg, 25 mg, and PBO groups, respectively, in the induction trial (Table). At Week 48, IBDQ remission was achieved by over 80% of pts, regardless of induction treatment, as compared to 42.1-62.7% at Week 8. At Week 48 an IBDQ response from Week 8 was achieved in 48.7%, 66.7%, 46.9%, 73.9% of pts in the 100 mg, 50 mg, 25 mg, and PBO groups, respectively. Conclusion Improvements in HRQOL were achieved and maintained with obefazimod treatment in adults with moderately to severely active UC, consistent with clinical efficacy endpoints. Table. IBDQ endpoints in the OLE study

P0572 Impact of objective motility MRI scoring of ileal Crohn’s disease on gastroenterologists treatment assessment: The CONTEXT Trial

Abstract Background Assessing small bowel (SB) Crohn’s Disease (CD) is challenging due to finite accuracy of Faecal Calprotectin and the invasive nature of ileocolonoscopy. While SB motility is a validated biomarker, its impact on clinical decision-making remains unstudied. This study aims to evaluate the influence of GIQuant lesion-specific motility score on clinical assessments in real-world settings. Methods 10 practising NHS gastroenterologists in 6 UK sites participated with each site identifying eligible CD patients. All patients had baseline and 1y follow up MRE as part of their clinical care including SB motility sequences. For both timepoints, a GIQuant score was derived by the reporting radiologist via an ROI placed in the most active SB segment (matched, if more than one), to which the gastroenterologist was initially blinded. After the second timepoint, gastroenterologists completed an eCRF grading treatment response, 12-month prognosis and surgical likelihood on a 6-point scale: much worse, somewhat worse, slightly worse, slightly better, somewhat better, or much better based on all available clinical information including imaging, but not the GIQuant scores. GIQuant scores from each scan timepoint were then revealed, and gastroenterologists updated their clinical impressions guided by the quantitative change in SB motility scores. Results 170 CD patients scanned between Nov 2017 and Dec 2023 (61% male, mean age 36±12yrs) were included. Disease was characterised as ileal (61%) or ileocolonic (39%), with behaviour classified as inflammatory (36%), stenosing (42%), or penetrating (21%). 59% of patients had a disease duration of &amp;gt;4yrs. (25,17%) patients had a single CD-related operation, and another 29 had multiple surgeries. Most patients (84%) were on biologics: 33% Adalimumab, 19% Ustekinumab, 16% Infliximab, and 9% Vedolizumab. GIQuant led to changes in clinical opinion in 43% of cases for disease status, 38% for 12-month prognosis, and 25% for surgical referral likelihood. Most adjustments were 1-step (e.g.,'somewhat worse' to 'slightly worse'), with fewer 2-step and 3-step changes (e.g.,'slightly worse' to much better') reflecting more substantial re-evaluations (Figure1). There was a change in direction of impression, e.g. slightly better to slightly worse or vice versa in (36,21%) cases for disease status, (31,18%) for 12-month prognosis and (15/143,10%) for surgical referral likelihood indicating that GIQuant scores may aid clinical evaluation. Conclusion Objective markers are urgently needed for effective management of SBCD. Scoring with GIQuant fundamentally changed the clinical impression in 21% of our cohort, supporting its role as an objective marker in CD management.