Nurses who have been responding to the COVID-19 pandemic are vulnerable to negative effects on their mental health from trying to balance caring for patients with ensuring safety and well-being for themselves, their families, and their friends.1 Although well-being should always be a focus for health care organizations and workers, it is even more essential in the midst of a health crisis. With the COVID-19 pandemic, there have been increasing challenges and precarious circumstances that can contribute to stress and burnout among health care professionals. For some nurses, the length of shifts, number of consecutive shifts, and on-call times have increased because of the surge in care demands, whereas others are managing possible cuts to their hours and pay. Nurses may be feeling pressure from possible redeployment to care areas for which they may be lacking skills to perform new tasks; and they could be dealing with equipment shortages, including ventilators for patients and personal protective equipment for themselves, both of which can create a sense of powerlessness. Outside of work, they could be subjected to stay-at-home orders or may have had to distance themselves from their own family and friends, resulting in less emotional support.2 This month’s lead feature article discusses tactics that can be used to support nurse well-being and prevent burnout all year long, along with some recommendations specific to times of public health crises. In fact, these general strategies can be an important jumping-off point for individual nurses and organization leaders struggling to maintain well-being for themselves and their teams during the pandemic. Individual nurses can start by focusing on meeting basic needs, such as getting enough sleep and physical activity; eating meals, ideally on a regular schedule; and staying in contact with friends and family. In these situations, it also is important for nurses to keep tabs on their feelings, so that they can recognize any worsening symptoms (e.g., trouble sleeping, feeling hopeless) early and, when needed, obtain support from colleagues, managers, or other health professionals.2 It is important for organization leaders to maintain critical infrastructure while providing support for their team members and being empathetic to their needs; this may require adapting existing protocols, scheduling, or roles. Leaders need to pay attention to the strain and pressure their nurses feel, such as if the shift hours are too long, the workloads are too high, or they are not receiving breaks. They should encourage and provide ways for their team members to express their concerns and ask questions, monitor and support their well-being by identifying and responding to their needs, and provide regular updates on how challenges are being addressed.2 Because of the added stress during public health emergencies, the well-being of nurses and other health care professionals should be made a priority, which will require dedication from organization leaders and the individuals themselves. Read this month’s lead feature article to learn more about implementing tactics to support nurse well-being in these situations and all year long.