Abstract
The present study was aimed at formulating thermoreversible in situ gel of local anesthetic by using xyloglucan based mucoadhesive tamarind seed polysaccharide (TSP) into periodontal pocket. Temperature-sensitive in situ gel of lidocaine hydrochloride (LH) (2% w/v) was formulated by cold method. A full 32 factorial design was employed to study the effect of independent variables concentrations of Lutrol F127 and TSP to optimize in situ gel. The dependent variables evaluated were gelation temperature (Y 1) and drug release (Y 2). The results revealed the surface pH of 6.8, similar to the pH of saliva. Viscosity study showed the marked increase in the viscosity of gel at 37°C due to sol-gel conversion. TSP was found to act as good mucoadhesive component to retain gel at the site of application in dental pocket. Gelation of formulation occurred near to body temperature. In vitro study depicted the fast onset of drug action but lasting the release (90%) till 2 h. Formulation F7 was considered as optimized batch, containing 18% Lutrol F127 and 1% tamarind seed polysaccharide. Thus, lidocaine hydrochloride thermoreversible in situ gel offered an alternative to painful injection therapy of anesthesia during dental surgery, with fast onset of anesthetic action lasting throughout the dental procedure.
Highlights
Periodontosis is a serious gum infection, which affects the supporting structure of teeth such as gums, periodontal ligaments, alveolar bones, and dental cementum
Periodontosis is caused by the bacteria that stick to the surface of tooth and multiply
Lidocaine hydrochloride loaded periodontal temperaturesensitive in situ gel was successfully developed by cold method using xyloglucan based mucoadhesive polymer Tamarind seed polysaccharide (TSP) for insertion into periodontal pocket to have painless treatment
Summary
Periodontosis is a serious gum infection, which affects the supporting structure of teeth such as gums, periodontal ligaments, alveolar bones, and dental cementum. Periodontosis is caused by the bacteria that stick to the surface of tooth and multiply Toxins produced by these bacteria in plaque, formed below the gum line, irritate the gums and stimulate an inflammatory response. The scaling and root planning is the common practice to cure this problem This scaling procedure needs the application of local and nerve block/infiltration anesthesia by painful needle therapy [3]. Gel remains on application site and enhances the residence time in the periodontal pocket. It is used both internally and externally in various products that are designed for animal and human use [8]. The dental gel can be rinsed out with water to stop the anesthetic effect after the treatment
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