Xenogenic acellular dermal matrix in immediate implant-based breast reconstruction following nipple/skin-sparing mastectomy

Abstract

Objective To explore the clinical outcomes of xenogenic acellular dermal matrix in immediate implant-based breast reconstruction following nipple/skin sparing mastectomy. Methods From January 2015 to June 2017, patients that underwent immediate implant-based breast reconstruction following nipple/skin-sparing mastectomy were retrospectively studied. Results 43 female patients with breast cancer were enrolled. A retrospective review was performed on patients that were reconstructed with either alloplastic reconstruction (group A, 18 breasts) or xenogenic acellular matrix dermal (group B, 25 groups). Differences in the average age, body mass index, numbers of diabetic patients, numbers of active smoker, and volume of implant between the two groups were not statistically significant (P>0.05). All patients were followed up from 3 to 28 months, with the middle time of 18, 7 months. Complications in both groups of patients were clinically recorded after operation. When comparing clinical outcomes, group A had fewer drain (523.17±62.18) ml vs (639.56±54.34) ml, and fewer days before drain removal (7.83±1.58) d vs (10.2±1.44) d. No significant difference was seen in terms of seroma, hematoma, delayed healing, infection, nipple necrosis, capsular contracture, or tumor recurrence. Conclusions The use of xenogenic acellular matrix dermal in immediate implant-based breast reconstruction following nipple/skin-sparing mastectomy is as safe and effective as alloplastic reconstruction. Key words: Breast cancer; Breast Reconstruction; Breast implantation; Acellular dermis