Autologous burn scar versus xenogenic acellular dermal matrix as a dermal substitute in microskin grafting

Abstract

Objective To compare the efficacy of autologous burn scar with porcine acellular dermal matrix ( ADM ) as a substitute inmicroskin grafting.Methods 14 patients with ?-degree burn underwent scar removal and microskin grafting within 3 to 7 after burn.In each patient,autologous burn scars were implanted in one limb ( scar side ),while porcine acellular dermal matrix was used as a dermal substitue in the other limb( dermis side ).The survival time of two types of skin coverage was observed and the wound healing rate in the implanted area was determined after surgery.Results The time for the implanted scar to completely detach from the burn wound was longer than that for porcine ADM [( 43.66 ±3.03 ) d vs.( 35.08 ± 2.54 ) d,P ＜ 0.01].The rate of wound healing for scar implant was significantly higher than that for porcine ADM 6 week after surgery [( 85.23 ± 5.13 )％ vs.( 63.23 ± 4.89 )％,P ＜ 0.01] at 6 weeks after the procedure.Conclusions Autologous scar can be used to replace xenogenic skin in microskin grafting,and it has a better efficacy than xenogenic ( porcine )acellular matrix and a better clinical value. Key words: Burns; Scar; Acellular dermis; Microskin grafting