Abstract
Whole Sporozoite Vaccination: Duration between Successive Immunization Dictates the Fate Of Protective Immunity
Highlights
Despite tremendous development of healthcare system, malaria in the 21st century still remains a serious challenge to human health to children under 5 years of age
In our recently published article[1], we have shown that the pattern of vaccination with radiation-attenuated sporozoites (RAS) determines the degrees of protection in mice and frequent immunization with RAS in optimum time duration helps in generating minimum threshold liver-stage (LS) specific CD8+ T cell memory responses leading to sterile protection
Remarkable efforts are being made for the development of an effective vaccine, but only RTS, S/AS01, (Mosquirix) a pre-erythrocytic subunit vaccine launched recently in the market has shown to induce antibody and CD4+ T cell response against sporozoite-expressed surface protein i.e., circum sporozoite protein (CSP)[23,24,25,26,27,28].The main target group of Mosquirix for active immunization are children aged between 6 weeks to 17 months against malaria caused by P. falciparum
Summary
Despite tremendous development of healthcare system, malaria in the 21st century still remains a serious challenge to human health to children under 5 years of age. Multiple doses of immunizations with radiation-attenuated sporozoites (RAS) is essential for establishing complete sterile protection against Plasmodium infection in mice as well as in humans.
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