Abstract
Kawasaki Disease, Multisystem Inflammatory Syndrome in Children: Antibody-Induced Mast Cell Activation Hypothesis
Highlights
IVIGd, corticosteroids, aspirin a5 consecutive days without identifiable source bMIS-C patients with coronary abnormalities may have had Kawasaki Disease (KD) and were misclassified cin one study, 54% of patients presented with thrombocytopenia dHigher incidence of IVIG resistance
We hypothesize that Multisystem Inflammatory Syndrome in Children (MIS-C) may be atypical KD or a KD-like disease associated with SARS-CoV-242 as a result of antibody-dependent enhancement activation of mast cells
We further hypothesize that KD and MIS-C may be induced in part by histamine and other inflammatory molecules released from activation of mast cells by Fc receptor-bound pathogen antibodies resulting in a hyperinflammatory response
Summary
IVIGd, corticosteroids, aspirin a5 consecutive days without identifiable source bMIS-C patients with coronary abnormalities may have had KD and were misclassified cin one study, 54% of patients presented with thrombocytopenia dHigher incidence of IVIG resistance. This hypothesis is supported by the presence of IgA plasma cells identified in inflamed tissues and coronary arteries of KD patients[14]. We hypothesize that MIS-C may be atypical KD or a KD-like disease associated with SARS-CoV-242 as a result of antibody-dependent enhancement activation of mast cells.
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