Abstract
The whitening effects of an oral care gel based on particulate microcrystalline hydroxyapatite, Ca5(PO4)3(OH), were tested in a 4-week observational pilot study. Patients were recruited from two dental practices in Germany. Participants were asked to complete a questionnaire regarding their personal perception of their tooth color and brightness as well as the level of dentin hypersensitivity at the baseline and after 4 weeks of twice daily use of an oral care gel with hydroxyapatite. Data of 25 patients with a mean age of 46 ± 16 years were analyzed. Various subjective whitening parameters showed a tendency to be improved after the 4-week use. Additionally, patients reported that symptoms of dentin hypersensitivity were significantly reduced (p < 0.05, 95% confidence interval (CI): (0.8; 2.4)), and the tooth surface was significantly smoother (p < 0.05, 95% CI: (0.54; 1.6)). In conclusion, microcrystalline hydroxyapatite is a promising whitening agent for oral care formulations and represents a biomimetic alternative to other whitening agents for daily dental care.
Highlights
Particulate hydroxyapatite, Ca5 (PO4 )3 (OH), is a multifunctional biomimetic active ingredient used in preventive oral health care [1,2,3,4,5,6], and has a wide range of applications in this field
It has been shown to remineralize both enamel and dentin, prevent caries [2,5,7,8,9,10,11,12], reduce bacterial colonization on teeth and dental surfaces [1,13], improve periodontal health [1,4,13,14,15], and improve symptoms associated with dentin hypersensitivity [3,16,17]
An important advantage of hydroxyapatite compared to other active ingredients in preventive oral health care is its high biocompatibility as it has no side effects when used in daily oral care [6,18,19,20,21]
Summary
Particulate hydroxyapatite, Ca5 (PO4 ) (OH), is a multifunctional biomimetic active ingredient used in preventive oral health care [1,2,3,4,5,6], and has a wide range of applications in this field. An important advantage of hydroxyapatite compared to other active ingredients in preventive oral health care is its high biocompatibility as it has no side effects when used in daily oral care [6,18,19,20,21]. Tooth whitening procedures are not recommended for those under the age of 18, as side effects may occur [23]. Hydroxyapatite-based oral care products are well-suited for all age groups
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