Abstract
Coronavirus is affecting millions of people world-wide. Coronavirus disease 2019 (COVID-19) is declared a pandemic by WHO. Severe acute respiratory syndrome corona virus 2(SARS-CoV-2) is the causative agent. The clinical presentations of SARS-CoV-2 infection range from febrile illness to pneumonia, ARDS and multi organ failures. Increasing scientific evidences have shown that abnormalities in routine laboratory test, particularly haematological parameters influence the outcome of the disease. Here variations in WBC profile in several clinical forms of COVID-19 patients are observed, The clinical course of the disease may change with haematological parameters such as lower total count of WBC, lymphocyte, higher neutrophil count, eosinophil count etc. By investigating haematological parameters of different clinical stage of RT-PCR positive 100 COVID-19 patients, statistically significant association (p value 0.001) of lymphocyte count with disease severity was found. It is also found that higher level of total count WBC, neutrophil count in severe group in comparison to mild and moderate groups but failed to reach any statistical significance. Moreover total count WBC and neutrophil count showed positive correlations but lymphocyte count, eosinophil count and monocyte count showed negative correlation with severity of disease. So, complete analysis of the haematological parameters will be very much helpful for early detection of complications & better control of the disease.
Highlights
INTRODUCTIONThe main mechanism for organ damage and inflammation is cytokines storm, especially in endothelial cells of pulmonary vessels with increased inflammatory cytokines such as macrophage chemo attractant protein-1, interleukin and 12 [7]
The pneumonia caused by novel coronavirus was named COVID-19
The third corona virus identified is the novel Corona virus (SARSCo-V-2) that causes pneumonia (COVID-19) which first broke in China in December 2019 [1]
Summary
The main mechanism for organ damage and inflammation is cytokines storm, especially in endothelial cells of pulmonary vessels with increased inflammatory cytokines such as macrophage chemo attractant protein-1, interleukin and 12 [7]. This virus initially undergoes viral replication in the respiratory tract. These cytokines act on bone marrow, responsible for inactivation of thrombocyte, leukocytes and other components [9] These inflammations cause changes in the function of several organs, leading to several changes in haematological parameters among different clinical stages of COVID-19 patients [11],[12]. COVID-19 has been shown to exert significant effects on the hematopoietic system
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