Abstract
Intradermal injections of 1–50 pmol leukotriene B 4, C 4, D 4 and E 4, (LTB 4, LTC 4, LTD 4 and LTE 4) were performed in healthy subjects and patients with recurrent urticaria. A wheal and erythema were seen 15 minutes after injection and were most marked after LTC 4 and LTD 4. LTE 4 also produced a wheal whereas the reaction to LTB 4 did not significantly differ from the saline control. When mixed with histamine no potentiation of the wheals was noted and no significant difference in reaction was observed between the healthy controls and those with urticaria.
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