Abstract
BackgroundThe risk factors for multi-drug resistant infection (MDRI) in the pediatric intensive care unit (PICU) remain unclear. It’s necessary to evaluate the epidemiological characteristics and risk factors for MDRI in PICU, to provide insights into the prophylaxis of MDRI clinically.MethodsClinical data of 79 PICU children with MDRI were identified, and 80 children in PICU without MDRI in the same period were selected as control group. The related children’s characteristics, clinical care, microbiologic data, treatments provided, and outcomes of the patients with were reviewed and collected. Univariate and multivariate logistic regression analyses were performed to identify the potential risks of MDRI in PICU.ResultsOf the diagnosed 79 cases of MDRI, there were28 cases of CR-AB, 24 cases of MRSA, 22 cases of PDR-PA,3 cases of VRE and 2 cases of CRE respectively. Univariate analyses indicated that the length of PICU stay, the duration of mechanical ventilation > 5 days, parenteral nutrition, coma, urinary catheter indwelling, invasive operation, 2 or more antibiotics use were associated with MDRIs (all p < 0.05); The logistic multiple regression analyses indicated that coma, parenteral nutrition, 2 or more antibiotics use and the duration of mechanical ventilation > 5 days were independent risk factors associated with MDRI (all p < 0.05).ConclusionsThis present study has identified several potentially modifiable risk factors for MDRI in PICU, it’s conducive to take appropriate measures targeting risk factors of MDRI for health care providers to reduce MDRI.
Highlights
The risk factors for multi-drug resistant infection (MDRI) in the pediatric intensive care unit (PICU) remain unclear
Multivariate regression analysis on the risk factors of MDRIs Unconditional logistic multiple regression analyses were further performed on the seven variables with significant differences in univariate analysis, the logistic multiple regression analyses indicated that coma, parenteral nutrition, 2 or more antibiotics use and the duration of mechanical ventilation > 5 d were independent risk factors associated with MDRIs respectively (Table 3)
Identifying risk factors for infection development caused by multidrug-resistant bacteria can help health care providers prevent nosocomial infections
Summary
The risk factors for multi-drug resistant infection (MDRI) in the pediatric intensive care unit (PICU) remain unclear. The emergence of a large number of pan-drug resistant strains poses great difficulties for treatment of pediatric patients [2]. The intensive care unit has become a high-risk area for hospital-acquired infections and drugresistant strains regarding its large number of special susceptible populations and its special diagnosis and. Certain risk factors are associated with nosocomial infections caused by drug-resistant organisms. In PICU, considering that the low immunity, serious condition, long hospitalization, mechanical ventilation, invasive examination and other factors related to the treatment of children, the incidence of MDRIs increases significantly, posing a great threat to children [4, 13]
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