Logistic regression analysis on risk factors of ventilator-associated hospital acquired pulmonary infection

Abstract

Objective To explore independent risk factors of ventilator-associated hospital acquired pulmonary infection in comprehensive ICU.Methods A prospective cohort study was made on patients with mechanical ventilation were hospitalized from October 2006 to June 2008.Several statistically significant risk factors were screened out with univariate analysis,then independent risk factors were determined with multivariate stepwise logistic regression analysis.Results The morbidity of ventilatorassociated hospital acquired pulmonary infection was 47.50% in this groups.Univariate analysis showed that age,hypoalbuminemia,history of chronic obstructive pulmonary emphysema,the duration of mechanical ventilation,the use of various antibiotics and the length of stay in ICU were statistically significant risk factors of pulmonary infection.While multivariate stepwise logistic regression analysis showed that the relative risk and 95% confident interval of the duration of mechanical ventilation,the use of various antibiotics were respectively 1.257 (1.004-3.587),P = 0.024;6.243 (4.013-39.525),P = 0.007.Conclusions The occurrence of ventilator-associated hospital acquired pulmonary infection is related to multiple clinical factors.The duration of mechanical ventilation and the use of various antibiotics are independent and significant risk factors of ventilator-associated hospital acquired pulmonary infection. Key words: Mechanical ventilation; Pulmonary infection; Intensive care unit; Risk factors; Logistic regression analysis