Abstract
Flucytosine-β-cyclodextrin and hydroxypropyl β-cyclodextrin water soluble inclusion complex were prepared by freeze drying method in distilled water. The formation of inclusion complex between β-cyclodextrins and flucytosine has been studied and fully described in our previous work [1]. In this paper we are describing the results obtained concerning the antifungal activity of this new compounds. As expected the new inclusion complexes presents a semnificative increase of the antifungal activity, illustrated by the reduction of the minimal inhibitory concentrations for 50 and 90% of the tested strains decreased. Also, the acute toxicity of the flucytosine β cyclodextrin and hydroxypropyl β cyclodextrin complex is smaller comparing with the pure drug, analyzed alone. These results recommend the described conjugates as future promising therapeutic agents.
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