Abstract
This study investigated the inclusion complex of Eucalyptus staigeriana essential oil (ESEO) formed with hydroxypropyl-β-cyclodextrin (HPCD) as a model system to determine which essential oil (EO) components were encapsulated in the complex. The ESEO/HPCD inclusion complex was prepared in aqueous solution and consequently analyzed by gas chromatography-mass spectrography (GC-MS), ultraviolet–visible spectroscopy (UV-VIS), thermogravimetric–differential thermal analysis (TG-DTA), 1H ROESY NMR, and molecular modeling. The results clearly showed that inclusion complexes had been successfully formed between ESEO and HPCD. It was demonstrated that the EO components did not form an inclusion complex with HPCD in equal proportions, but certain EO components were preferentially encapsulated. Components such as alcohols and aldehydes were preferentially encapsulated by HPCD, leading to higher concentrations of these compounds in the complex. This implies that encapsulation of EOs by forming inclusion complexes with HPCD may alter their composition in the complexes with potential changes in their properties such as antimicrobial activity.
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