Abstract
There are two problems that hinder the use of double emulsions in pharmacies: large-scale equipment not available for one-step emulsification and obtaining a double emulsion and ingredients available to replace the tension-active agents as primary emulsifier because these surfactants are toxic. To overcome these difficulties, a two-stage emulsification strategy has been developed, first generating a water-in-oil Pickering emulsion stabilized by magnesium oxide particles and then the double W/O/W emulsion, thereby reducing significantly the amount of voltage-active. Pickering emulsions are surfactant-free emulsions, stabilized by colloidal particles. These systems are experiencing renewed interest on the one hand, because it is preferable to limit the use of synthetic surfactants for ecological reasons, and on the other hand, because the functionalization of particles has undergone recent advances. It is possible to make very simple calibrated emulsions of controlled size, exploiting a phenomenon called limited coalescence. The Bancroft rule served as a model for the formulation. The emulsification was carried out using a rotor stator mixer. The stability of these emulsions has been studied using several parameters (pH, conductivity, droplet size, dye test). The dye test and the conductivity measurement confirmed the W/O nature of the emulsion and W/O/W nature of the double emulsion. This study showed that we were able to develop a saturated double W/O/W emulsion.
Highlights
The general objective of this work was to produce a double Pickering W/O/W emulsion stabilized by particles of magnesium oxide (MgO) in an emulsion stabilized by a surfactant
For simple emulsions we have found that the compositions having 0.15 g of petrolatum, 5% of particle, 15 ml of water and 7 ml of oil are stable
First a Pickering water-in-oil emulsion stabilized by MgO magnesium oxide particles was prepared, the second oil-in-water emulsion stabilized by Cremophor ELP which is an active nonionic voltage
Summary
In other words the stabilization of internal drops in drops of larger diameters These internal emulsions can be Pickering emulsions. Pickering emulsions are dispersions of two immiscible liquids stabilized by solid particles. They are generally made up of three components: a phase, an oily phase and the stabilizing particles. The effect of stabilization of emulsions by fine particles has been known for about a century. These emulsions are called the "Pickering emulsion" after one of the first researchers to describe this type of stabilization in 1907. He established that particles can act as
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