Abstract
Pickering emulsions are systems without surfactants, stabilized by solid particles. These emulsions are experiencing a renewed interest, on the one hand, because it is preferable to limit the use of synthetic surfactants for toxicological and environmental reasons and, on the other hand, the need to make new formulations in order to control the drug release patterns by encapsulation or controlled release. Thus, we were interested in the formulation and evaluation of W/O Pickering emulsions stabilized by particles of magnesium oxide with paracetamol in the internal phase and griseofulvin in the external phase. The Bancroft rule served as a model for the formulation. The emulsification was carried out by progressively adding an aqueous phase dispersed in an oil-dispersing phase using a turbo rotor stator mixer. The stability of these emulsions was studied using several parameters (droplet size, pH, viscosity, conductivity ...) and the qualitative and quantitative analysis of the active ingredients by UV-visible spectrophotometry. The results obtained showed that the dye test and the conductivity measurement confirmed the W/O nature of these emulsions. Some parameters such as droplet size, pH and viscosity were strongly influenced by the amounts of magnesium oxide particles and the two active ingredients used. The qualitative and quantitative analysis of the active ingredients confirmed the presence of griseofulvin in the oil phase and paracetamol in the aqueous phase. Thus, we have succeeded in developing a stable W/O Pickering emulsion with magnesium oxide particles. In addition, we were able to incorporate paracetamol into the dispersed phase and griseofulvin into the dispersing phase of the emulsion.
Highlights
We were interested in the formulation and evaluation of W/O Pickering emulsions stabilized by particles of magnesium oxide with paracetamol in the internal phase and griseofulvin in the external phase
Pickering emulsions are dispersions of two immiscible liquids stabilized by solid particles
The emulsions are all stable, better stability was observed with the emulsions containing 6.8 wt% of Magnesium Oxide (MgO), especially those containing only one active substance (Figure 1)
Summary
Pickering emulsions are dispersions of two immiscible liquids stabilized by solid particles. The stabilizing effect of emulsions by solid particles has been known for about a century These emulsions are called “Pickering Emulsions” named after one of the earliest researchers who described this type of stabilization. The adsorption of solid particles at the oil-water interface is strong and irreversible. The particle adsorption or desorption energy [ΔE = γHE πr2(1 ± cosθ)2] is mainly related to their ability to be partially wetted by the two phases of the emulsion [4] [5] [6] This wetting of the particles is characterized by an angle of contact between the aqueous phase, the oil phase and the solid particles, measured on the side of the aqueous phase. The Magnesium Oxide used in this study can be used in several fields In food, it is used as a food additive. It can be used as an antacid in heartburn [11]
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