Abstract
Magnetic Resonance Imaging based brain segmentation and volumetry has become an important tool in clinical routine and research. However the impact of the used hardware is only barely investigated. This study aims to assess the influence of scanner manufacturer, field strength and head-coil on volumetry results. 10healthy subjects (27.4 ± 1.71 years) were prospectively examined in aPhilips Achieva 1.5T, Philips Ingenia CX 3T, Siemens MAGNETOM Aera 1.5T and Siemens MAGNETOM Vida 3T, the latter equipped with three different head coils, within one day. Brain volumetry of the whole brain, total white and grey matter, the cortical grey matter of the supratentorial lobes as well as regions important for the differentiation of neurodegenerative diseases of the dementia and movement disorder spectrum and the ventricular system was performed using the CE-certified software mdbrain by mediaire (Berlin, Germany). Both raw volumetry results and percentile allocation provided by the software were analysed. This study reveals significantly different volumetry results for all examined brain regions beside the ventricular system between the different MRI devices but comparable results between the different head coils. When examining the percentile allocation provided by used software, the Intraclass-Correlation-Coefficient (ICC) values were even lower than the raw volume ICC values ranging from poor to excellent correlation. The present study reveals highly relevant results that need to be considered both in clinical routine when analysing follow-up examinations from different scanner types and clinical research, especially when planning longitudinal and/or multicentre studies.
Published Version
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