Abstract
Deficiency of Vitamin D in the Indian subcontinent is emerging as a major noninfectious epidemic. To correlate vitamin D deficient children with the asthma and allergic rhinitis classification and pulmonary function tests. We studied 66 children with asthma and allergic rhinitis between 6 to 12 years of whom 33 cases were administered Vitamin D and 33 controls who were not given Vitamin D. The ethical committee approval was taken. It was a prospective, randomised and comparative study. Data was analysed using mean, standard deviation and pairedt test. The study revealed 42 (63.6%) males and 24 (36.4%) females. The Asthma classification depicted mild persistent in 37 (56.1%) followed by intermittent 16 (24.2%) and moderate persistent 12 (18.2%). Maximum cases of allergic rhinitis were moderate persistent 42 (63.6%). The Children who received vitamin D had significant improvement of Forced Expiratory Volume in the first second (FEV1, p-0.000), Forced Vital Capacity (FVC, p-0.005), FEV1: FVC% (p-0.002) and Peak Expiratory Flow Rate (PEFR, p-0.000). The control group showed significant improvement in the PEFR parameter (p- 0.0077). The case group showed marked improvement in the lung functions. Adherence to the duration of therapy for a period of 10 weeks with Vitamin D is mandatory.
Highlights
Asthma and Allergic rhinitis is a cause for major public health concern worldwide [1]
We studied 66 children with asthma and allergic rhinitis between 6 to 12 years of whom 33 cases were administered Vitamin D and 33 controls who were not given Vitamin D
Arshi et al found that patients on inhaler therapy along with Vitamin D (VD) showed improvement in FEV1 compared to the group of asthmatics on inhaler therapy alone [9]
Summary
Asthma and Allergic rhinitis is a cause for major public health concern worldwide [1]. There have been recent studies on the benefits of administering Vitamin D (VD) in childhood asthma and allergic rhinitis [2]. VD has a role in both the innate and adaptive immune responses [3], clinicians have focused on its impact in atopic conditions. It decreases exacerbations, improves pulmonary functions, enhances steroid responsiveness thereby improving quality of life [4]. We have assessed the Pulmonary function (PFT) test values before and after VD administration along with inhaler therapies
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