Abstract
Objective: To investigate the peritoneal mast cell stabilization activity of Ziziphus xylopyrus extracts. Materials and Methods: Ziziphus Xylopyrus L. (family- Rhamnaceae) stem part was successively extracted with ethanol and aqueous to prepare extract of the plant. The extracts of Ziziphus Xylopyrus (Z. xylopyrus) were evaluated for stabilization of mast cell in rat for the evaluation of Hypersensitivity type I allergic reaction in animal models. The extract of Z. xylopyrus ethanolic and aqueous (1, 10 and 100 μg/ml) was evaluated for peritoneal mast cell stabilization activity in rat mesenteric preparation induced by C 48/80. Result: Preliminary phytochemical analysis revealed the presence of carbohydrates, fixed oil, proteins, alkaloids, glycosides, flavonoids and phenolic compounds. The ethanolic and aqueous extracts of Z. xylopyrus showed dose dependent increase in the number of intact cells when compare with C 48/80 at the concentration of 10 and 100 μg/ml. It virtues further work towards the isolation of phyto constituents from this plant. Conclusion: This finding provides evidence that the Z. xylopyrus inhibits mast cell-derived immediate-type allergic reactions and mast cell degranulation. Z. xylopyrus has a potential as allergic anti-asthmatic agent.
Highlights
Ziziphus xylopyrus (Retz) Willd is a large, straggling shrub or a small tree, armed with spines, up to 4 m in height
Z. xylopyrus has a potential as allergic anti-asthmatic agent
The present study was proposed to find out the alternative herbal medicines which counter the allergic response by reducing the side effect of synthetic drugs. In this direction we evaluate the mast cell stabilization property of Z. xylopyrus stem extracts on peritoneal mesentery preparation
Summary
Ziziphus xylopyrus (Retz) Willd (family- Rhamnaceae) is a large, straggling shrub or a small tree, armed with spines, up to 4 m in height. Z. xylopyrus is commonly known as Jujab [1]. It is found in Pakistan and China, North-Western India, Utter Pradesh, Bihar, Central and South India [2]. Z. xylopyrus is used in Pyorrhoea and to check oogenesis [3,4]. India traditionally fresh stem bark of Z. xylopyrus species are chewed with 1-2 peppers (Piper nigrum) for the treatment of cough. Bark and leaf powder paste are applied externally for chest pain arising from cough [7]. This plant is widely used in Turkish medicine as a potent sedative [8]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
