Abstract
Abstract: The loading and unloading of a drug into a nanoparticle are the first stages in the delivery of a nanodrug. This work investigates the loading of curcumin via soft hydrolysis of silane using iron oxide-silane core-shell nanoparticles. Additionally, the study examines the sustained release of curcumin from the core-shell nanoparticles over a period of 70 hours at a physiological pH. The release ability is studied using the absorption spectral technique. The interaction of DNA is studied using the emission spectral technique. Drug delivery applications should involve interactions between the released drug and the biomolecules of the biological systems. Therefore, it can be concluded that this system is used to study the interaction between curcumin and DNA and vitamin Cinduced cleavage.
Published Version
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