Abstract
SummaryThe influence of ascorbic acid deficiency on the production of collagen and acid mucopolysaccharides in carrageenan-induced granulomas is studied. Ascorbic acid deficiency results in the formation of a granuloma, which is poor in hydroxyproline, an animo acid specific of the collagen molecule. Furthermore, the acid mucopolysaccharides of the ground substance are changed, both qualitatively and quantitatively. The concentration of hexosamine and uronic acid increases during development of granulomas in ascorbic acid-deficient animals, and in granulomas 10 and 14 days old the concentration is increased significantly as compared with control granulomas. At the same time a decrease in the fucose concentration is observed, which is indicative of a decrease in the glycoproteinbound hexosamine. Hence, the increase in the hexosamine content is presumably caused exclusively by an increase in the content of acid mucopolysaccharides. The carbazole to orcinol ratio falls significantly during the development of normal control granulomas, presumably as a manifestation of a relative increase in the content of chondroitin sulfate B. During ascorbic acid deficiency, acid mucopolysaccharides are formed with a higher carbazole to orcinol ratio than that found in animals adequately supplied with ascorbic acid.
Published Version
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