Abstract
SummaryThe author has reviewed the literature pertaining to the biosynthesis of collagen emphasizing those steps which are peculiar to the formation of this protein, i. e., hydroxylation of lysine and proline, the formation of subunits and of intra- and extra-molecular bonds. An account is given of the effects of vitamins and hormones on collagen synthesis. Possible alterations occurring in disease states such as hypothyreosis, acromegaly, Marfan's and Ehler-Danlo's syndromes are discussed.
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