Vinblastine and vincristine as anticancer molecules stopping the tubulin dimers

Abstract

Vinblastine is belonging to vinca alkaloid family which is a chemical analogue of vincristine molecules. It has a high potential for attaching to tubulin of microtubules, therefore inhibiting the assembly of that biomolecules. Human EGFRs receptors are cell surfaces receptors proteins including three different domains which are known extracellular ligand-binding domain, trans-membranes hydrophobic domain and cytoplasmic C-terminal domain with tyrosine kinase. The Chemical & physical vibrational spectral data obtained from NMR, NBO and IR spectra based on the results of the theoretical calculations using DFT and HF methods. The fundamental vibrational modes were characterized depending on the stabilities of Herceptin in different dielectric constants. Thus, the goal of this article is to evaluate and quantify and qualify of the mechanism in various solvents.