Vergleich der Wirkung verschiedener Acidosen (NH4Cl, CaCl2, Acetazolamid) auf die Lungenbel�ftung beim Menschen

Abstract

In seven healthy subjects acidosis was induced by NH4Cl, by CaCl2 or by acetazolamide (diamox). The response of respiratory minute volume to inhaled CO2 mixtures was studied in control and acidosis experiments. The arterial and endexpiratory CO2-tensions were determined simultaneously. The respiratory minute volumes were plotted against arterial or alveolar CO2 tensions (CO2 response curve). By interpolation in the CO2 response curves the lung ventilation in acidosis and in the control experiment could be compared at equal CO2 tensions. 1. Conclusions obtained with endexpiratory and with arterial CO2 tension measurements were coinciding. 2. The mean slope of the curves describing the dependance of lung ventilation upon arterial CO2 tension was not significantly altered in acidosis. The effect of acidosis is a parallel shift of the curve to higher ventilation or lower CO2 tension. 3. No significant difference in the response of lung ventilation to acidosis could be detected between NH4Cl, CaCl2 or acetazolamide acidosis. 4. If ventilations at equal CO2 tensions were compared, the effect of acidosis on lung ventilation was found to be in the average 2.01 min−1 per −0.01 p h change or 2.7 l min−1 per −1 meq l−1 change of whole blood buffer base.