Abstract
Changes in hepatic hemodynamics during blood pressure oscillations caused by the side pressure exertion procedure (SPEP) were studied in anesthetized rabbits. The brain was excluded from systemic circulation except for one of the common carotids, which was compressed with stepwise elevated pressure. In normovolemia, the hepatic arterial flow (HAF) increased as the systemic arterial pressure (SAP) rose up to 140 mmHg, and then decreased as SAP rose further. With the rise of SAP, the portal venous flow (PVF) initially rose slightly, followed by a nearly constant decrease. Hemorrhaging influenced slightly the changes of HAF and PVF with the SAP rise. After volume loading, SAP and PVF markedly increased but HAF changed little. However, the initial increase in HAF with the SAP rise was markedly depressed by volume loading. PVF conspicuously decreased without initial increase with the rise in SAP. The hepatic vascular bed has a mechanism that prevents expected decrease of blood flow after hemorrhaging and during neurogenic hypertension. The interaction among HAF, PVF, and PVP may be involved in this mechanism.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
