Abstract
Thyroid cancer is an internationally important health problem. The aim of this exploratory study was to evaluate whether significant changes in the thyroid tissue levels of Br, Ca, Cl, I, K, Mg, Mn, and Na exist in the malignantly transformed thyroid. Thyroid tissue levels of eight chemical elements were prospectively evaluated in 41 patients with thyroid malignant tumors and 105 healthy inhabitants. Measurements were performed using non-destructive instrumental neutron activation analysis with high resolution spectrometry of short-lived radionuclides. Tissue samples were divided into two portions. One was used for morphological study while the other was intended for chemical element analysis. It was found that contents of Br, Cl, K, Mg, and Na were significantly higher and content of I was drastically lower in cancerous tissues than in normal tissues. Thus, the study showed that the malignant transformation was accompanied by considerable changes in chemical element contents of thyroid parenchyma.
Highlights
IntroductionThyroid cancer (TC) incidence has dramatically increased in the recent decades.[1] During the same period no other cancer has increased as much as TC
Thyroid cancer (TC) is the most common endocrine malignancy
Thick-needle puncture biopsy of suspicious nodules of the thyroid was performed for every patient, to permit morphological study of thyroid tissue at these sites and to estimate their chemical element contents
Summary
TC incidence has dramatically increased in the recent decades.[1] During the same period no other cancer has increased as much as TC. The etiology of TC is unknown, several risk factors including deficiency or excess of such micronutrient as iodine (I) have been well identified.[6,7,8,9,10,11,12,13,14,15,16,17] It was reported that incidence of TC and mortality from this disease increases progressively with advancing age.[18,19] For example, a 37-fold increase in hazard ratio from age 70 years was showed in the study of 3664 TC patients that received surgery and adjuvant treatment at Memorial Sloan Kettering Cancer Center from the years 1985 to 2010.19
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