Abstract
Background: Thyroid cancer is an internationally important health problem. The aim of this exploratory study was to evaluate whether significant changes in the thyroid tissue levels of Br, Cu, Fe, Rb, Sr, and Zn exist in the malignantly transformed thyroid. Methods: Thyroid tissue levels of six trace elements (Br, Cu, Fe, Rb, Sr, and Zn) were prospectively evaluated in 41 patients with thyroid malignant tumors and 105 healthy inhabitants. Measurements were performed using 109Cd radionuclide-induced energy-dispersive X-ray fluorescent analysis Tissue samples were divided into two portions. One was used for morphological study while the other was intended for trace element analysis. Results: It was found that contents of Br, Cu, and Rb were significantly higher (approximately 10, 3.4, and 1.4 times, respectively) and content of Zn were slightly, but significantly, lower (25%) in cancerous tissues than in normal tissues. Conclusions: There are considerable changes in trace element contents in the malignantly transformed tissue of thyroid.
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