Value of serum MCP-1 and sICAM-1 in neonates with hypoxic-ischemic encephalopathy

Abstract

Objective To study the levels of serum MCP- 1 and sICAM- 1 in neonates with hypoxicischemic encephalopathy(HIE)and to explore the clinical value of serum MCP- 1 and sICAM- 1 for judgment and prognosis of brain damage in neonates with HIE. Methods The levels of serum MCP- 1 and sICAM-1 in the 1st and 7th day after birth of the 53 cases term infant with HIE(29 cases were mild HIE,15 cases were moderate HIE and 9 cases were severe HIE)were measured by enzyme linked immunosorbent assay(ELISA), and compared with 20 cases of normal newborns. Results The levels of serum MCP- 1 and sICAM- 1 in mild, moderate and severe HIE groups were all significantly higher than those in controls(P< 0.05); With increasing of the degree of brain injury, the levels of serum MCP- 1 and sICAM- 1 increased(P< 0.05); Compared with acute period(the 1st day after birth), the levels of serum MCP- 1 and sICAM- 1 were clearly decreased in recovery stage(the 7th day after birth)in all HIE groups. Conclusion MCP-1 and sICAM-1 may play important roles in the pathogenesis of neonatal HIE and have clinical value in the diagnosis and treatment. Key words: Hypoxia-ischemia encephalopathy; MCP-1; sICAM-1; Brain injury