Abstract
This work is devoted to a new approach to use of the inhibitor of glutamate-ionotropic NMDA-receptor - ketamine in treatment of rat malignant gliomas. Optimal ketamine concentrations for inhibition of tumor-associated inflammation in gliomas was found through measurement of blood cells aggregation in vitro in patients with gliomas. For the first time, the method of surface plasmon resonance was used to determine the degree of blood cell aggregation as the II phase of inflammation. Experiments for measure of ketamine antitumor activity were performed using the high-invasive and malignant strain of the rat glioma 101.8. The correlation between antitumor activity and blood cells aggregation was found. Unlike highly toxic preparations administered during human gliomas chemotherapies, low doses of ketamine is nontoxic, efficacious and it does not produce side effects.
Highlights
Brain gliomas pose a complicated problem in neurosurgical practice
The decrease in the shift value of surface plasmon resonance (SPR) curves for blood cells is indicative of enhancement of the aggregation level for these cells and, indirectly, of lowering the electric charge on cell membranes
In comparison with corresponding values for patients with trauma brain injury, they remain higher, which can indicate the availability of a subacute inflammation process or microinflammation inherent to malignant gliomas
Summary
On the average a life span with gliomas of the fourth degree ranges from 6 to 12 months. In recent years clinical investigations have shown that development of tumor-associated inflammation process stimulates growth and progression of malignant tumors, including gliomas [1,2,3]. In the latter case, glutamate acts on their progression mediately via a tumor microenvironment (TM) [4]. Long-term administration of drugs possessing anti-inflammatory action promotes a slowdown of the growth of gliomas and increases the life span of patients with these diseases [5]. The prolonged usage of the most of these drugs (aspirin, anti-inflammation drugs of nonsteroid and hormonal action) produces a side effect on a human organism
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