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Abstract
Utilization of 1,2-Naphthoquine-4-Sulfonate (NQS) for Development and Validation of Stability indicating HPLC method for the Simultaneous Analysis of Amlodipine, Hydrochlorothiazide and Valsartan in Pharmaceutical Formulation
Highlights
IntroductionAmlodipine/valsartan/hydrochlorothiazide (HCTZ) is a marketed dose combined of the well established antihypertensive agents amlodipine (AML) (a calcium channel antagonist), valsartan (VAL) (an angiotensin II receptor antagonist), and HCTZ (a thiazide diuretic) in patients with moderate or severe hypertension
Amlodipine/valsartan/hydrochlorothiazide (HCTZ) is a marketed dose combined of the well established antihypertensive agents amlodipine (AML), valsartan (VAL), and HCTZ in patients with moderate or severe hypertension
The triple combination dose was found to be more effective in reducing blood pressure and providing overall blood pressure control than the dual combination therapies regardless of age, race, gender, ethnicity, or hypertension severity [1, 2]
Summary
Amlodipine/valsartan/hydrochlorothiazide (HCTZ) is a marketed dose combined of the well established antihypertensive agents amlodipine (AML) (a calcium channel antagonist), valsartan (VAL) (an angiotensin II receptor antagonist), and HCTZ (a thiazide diuretic) in patients with moderate or severe hypertension. The US Food and Drug Administration (FDA) and the European Medicines Agency have approved a triple fixed-dose combination of AML, HCT and VAL. The triple combination dose was found to be more effective in reducing blood pressure and providing overall blood pressure control than the dual combination therapies regardless of age, race, gender, ethnicity, or hypertension severity [1, 2]. AML tablets are formulated as white tablets equivalent to 2.5, 5, and 10 mg of AML for oral administration. AML is formulated as the besylate salt of AML, a longacting calcium channel blocker [3]
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