Abstract
Objective: The objective of this review is to put a light on the development of lamotrigine and its active pharmaceutical ingredients formulation with proper demonstration.
 Method: In the present work, one of the most imperative spectrophotometric method which is RP-HPLC method has been developed for the quantitative estimation of lamotrigine in bulk and pharmaceutical formulations.
 UV spectrophotometric method which involves the determination of Lamotrigine in bulk and in bulk drug and pharmaceutical formulation has maximum absorption at 307.5nm in methanol. It obeys Beer’s and Lambert’s law in the concentration range of 5-45 µg/ml.
 A rapid and sensitive RP- HPLC Method with UV detection (270 nm) for routine analysis of Lamotrigine formulation was developed. Chromatography was performed with mobile phase containing a mixture of methanol and Phosphate buffer (65:35v/v) with flow rate 1.0 ml/min. In the range of 20-100 µg/ml, the linearity of lamotrigine shows a correlation co-efficient of 0.9998. The proposed method was validated by determining sensitivity and system suitability parameters.
Highlights
Repeated administration of medication and its significant variations of drug level in the blood are common disadvantages of traditional dosing techniques of drug delivery
Cellulose ethers such as hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC) and sodium carboxymethyl cellulose (Na CMC), acrylic methacrylic acid copolymers (Eudragits) such as Eudragit RL and RS, and some natural gums such as anthropic gum and gum, polymers are widely used as release retarders [6]
UV/visible spectrophotometry method [Tables 1 and 2] To recapitulate, the above given tables which perceive the overall data of the research shows different parameters of lamotrigine and its API formulation with distinct values
Summary
Repeated administration of medication and its significant variations of drug level in the blood are common disadvantages of traditional dosing techniques of drug delivery. Lamotrigine, an anti-epileptic; drug approved in the United States to treat partial seizures and bipolar disorder, is classified in BCS Class II, and its oral bioavailability is approximately 98% [7,8]. It is commercially available as immediaterelease and extended-release formulations in various dosages such as 25 mg, 50 mg, and 100 mg. Examine the effect of two independent variables (factors),that is, the amount of HPMC K4M and HPMC K100M, on the dependent variables, that is, T50%, t10%, k1 (time required to release 50% of the drug, time required to release 10% of the drug from the dosage form, first-order rate constant, respectively)
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